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Cwc22 Gene Detail
Summary
  • Symbol
    Cwc22
  • Name
    CWC22 spliceosome-associated protein
  • Synonyms
    MGC:7531
  • Feature Type
    protein coding gene
  • IDs
    MGI:2136773
    NCBI Gene: 80744
  • Alliance
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr2:77895653-77946356 bp, - strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 2, 46.45 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    347 from dbSNP Build 142
  • Strain Annotations
    17
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2136773
protein coding gene Chr2:77881159-77946375 (-)
129S1/SvImJ MGP_129S1SvImJ_G0025874
protein coding gene Chr2:78347153-78420570 (-)
A/J MGP_AJ_G0025851
protein coding gene Chr2:75321601-75388009 (-)
AKR/J MGP_AKRJ_G0025820
protein coding gene Chr2:77318191-77395177 (-)
BALB/cJ MGP_BALBcJ_G0025846
protein coding gene Chr2:75481812-75547391 (-)
C3H/HeJ MGP_C3HHeJ_G0025606
protein coding gene Chr2:77540541-77592504 (-)
C57BL/6NJ MGP_C57BL6NJ_G0026293
protein coding gene Chr2:80646532-80715088 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0023696
protein coding gene Chr2:72679253-72743338 (-)
CAST/EiJ MGP_CASTEiJ_G0025068
protein coding gene Chr2:77925903-77997823 (-)
CBA/J MGP_CBAJ_G0025587
protein coding gene Chr2:83633081-83690270 (-)
DBA/2J MGP_DBA2J_G0025718
protein coding gene Chr2:74879698-74946983 (-)
FVB/NJ MGP_FVBNJ_G0025680
protein coding gene Chr2:74277583-74343367 (-)
LP/J MGP_LPJ_G0025806
protein coding gene Chr2:78213457-78285706 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0025711
protein coding gene Chr2:85428198-85501340 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0026349
protein coding gene Chr2:77448258-77516757 (-)
PWK/PhJ MGP_PWKPhJ_G0024811
protein coding gene Chr2:74886616-74928411 (-)
SPRET/EiJ no annotation
WSB/EiJ MGP_WSBEiJ_G0025137
protein coding gene Chr2:77932209-78101451 (-)



Homology
more
  • Human Ortholog
    CWC22, CWC22 spliceosome associated protein homolog
  • Vertebrate Orthologs
    11
  • Human Ortholog
    CWC22, CWC22 spliceosome associated protein homolog
    Orthology source: HomoloGene, HGNC
  • Synonyms
    EIF4GL, fSAPb, NCM
  • Links
    NCBI Gene ID: 57703
    neXtProt AC: NX_Q9HCG8
    UniProt: Q9HCG8

  • Chr Location
    2q31.3; chr2:179944876-180007359 (-)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 6048
    1 human;1 mouse;2 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: CWC22
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    4 phenotypes from 1 allele in 1 genetic background
    13 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 80744 NCBI Gene Model | MGI Sequence Detail 50704 C57BL/6J ±  kb
transcript NM_030560 RefSeq | MGI Sequence Detail 3452 C57BL/6  
polypeptide Q8C5N3 UniProt | EBI | MGI Sequence Detail 908 Not Applicable  
For the selected sequence
Protein
Information
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Molecular
Reagents
less
  • All nucleic 17
    cDNA 17

    Microarray probesets 9
Other
Accession IDs
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MGI:2138849, MGI:2139123, MGI:3034792
References
more
  • Summaries
    All 40
    Developmental Gene Expression 3
    Gene Ontology 3
    Phenotypes 13
  • Earliest
    J:80000 The FANTOM Consortium and The RIKEN Genome Exploration Research Group Phase I & II Team, Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Nature. 2002;420:563-573
  • Latest
    J:269738 Guerreiro I, et al., Reorganisation of Hoxd regulatory landscapes during the evolution of a snake-like body plan. Elife. 2016 Aug 1;5

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources
Funding Information
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last database update
10/01/2019
MGI 6.14
The Jackson Laboratory