Glp2r
Gene Detail

Symbol Name ID

Glp2r glucagon-like peptide 2 receptor MGI:2136733

Synonyms

9530092J08Rik, GLP-2

Feature Type

protein coding gene

Genetic Map

Chromosome 11

41.13 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)

Sequence Map

Chr11:67661502-67771153 bp, - strand From VEGA annotation of GRCm38   109652 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:3132  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken

Protein SuperFamily: G protein-coupled receptor, peptide hormone receptor type
Gene Tree: Glp2r

Human homologs

Human Homolog		GLP2R, glucagon-like peptide 2 receptor
NCBI Gene ID		9340
neXtProt AC		NX_O95838
Human Chr (Location)		17p13.3; chr17:9729381-9793022 (+)  GRCh37.p10

Alleles and phenotypes

All alleles(7) : Targeted(7)
 

Mice homozygous for a null mutation display defects in Paneth cell physiology, increased small bowel bacterial loads, and increased susceptibility to small bowel injury.

 

Gene Ontology (GO) classifications

All GO classifications: (16 annotations)

Process	adenylate cyclase-modulating G-protein coupled receptor signaling pathway, cell surface receptor signaling pathway, ...
Component	integral to membrane, membrane, ...
Function	glucagon receptor activity, G-protein coupled receptor activity, ...

External Resources: FuncBase

Expression

Literature Summary: (1 records)
Data Summary: Results (27)    Tissues (4)    Images (14)
Theiler Stages: 23

Assay Type	Results
RNA in situ	27

cDNA source data(3)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(3) cDNA(3)
Microarray probesets(1)

Other database links

VEGA Gene Model	OTTMUSG00000005929 (Evidence)
Ensembl Gene Model	ENSMUSG00000049928 (Evidence)
Entrez Gene	93896 (Evidence)
UniGene	118883
DFCI	TC1594188, TC1598616
DoTS	DT.91377332, DT.94128158
NIA Mouse Gene Index	U032937
Consensus CDS Project	CCDS24860.1
International Mouse Knockout Project Status	Glp2r

Sequences

Length	Strain/Species
genomic	OTTMUSG00000005929	VEGA Gene Model | MGI Sequence Detail	109652	C57BL/6J
transcript	OTTMUST00000013197	VEGA | MGI Sequence Detail	4873	Not Applicable
polypeptide	OTTMUSP00000006124	VEGA | MGI Sequence Detail	512	Not Applicable

All sequences(28) RefSeq(2) UniProt(4)

Polymorphisms

SNPs(369 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR001879	GPCR, family 2, extracellular hormone receptor domain
InterPro	IPR017981	GPCR, family 2-like
InterPro	IPR000832	GPCR, family 2, secretin-like
InterPro	IPR017983	GPCR, family 2, secretin-like, conserved site
Protein Ontology	PR:000008041	glucagon-like peptide 2 receptor

References

(Earliest) J:69966 Lovshin J, et al., Glucagon-like peptide (GLP)-2 action in the murine central nervous system is enhanced by elimination of GLP-1 receptor signaling. J Biol Chem. 2001 Jun 15;276(24):21489-99
(Latest) J:189593 Guan X, et al., GLP-2 receptor in POMC neurons suppresses feeding behavior and gastric motility. Am J Physiol Endocrinol Metab. 2012 Oct 1;303(7):E853-64
All references(29)

Other accession IDs

MGI:2441752