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Hils1 Gene Detail
Summary
  • Symbol
    Hils1
  • Name
    histone H1-like protein in spermatids 1
  • Synonyms
    TISP64
  • Feature Type
    protein coding gene
  • IDs
    MGI:2136691
    NCBI Gene: 54388
  • Alliance
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr11:94967593-94968456 bp, + strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 11, 59.01 cM, cytoband C
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    47 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2136691
protein coding gene Chr11:94967593-94968456 (+)
129S1/SvImJ MGP_129S1SvImJ_G0018972
protein coding gene Chr11:97150742-97151605 (+)
A/J MGP_AJ_G0018940
protein coding gene Chr11:93226660-93227514 (+)
AKR/J MGP_AKRJ_G0018910
protein coding gene Chr11:96108724-96109578 (+)
BALB/cJ MGP_BALBcJ_G0018913
protein coding gene Chr11:93698382-93699245 (+)
C3H/HeJ MGP_C3HHeJ_G0018727
protein coding gene Chr11:96238488-96239342 (+)
C57BL/6NJ MGP_C57BL6NJ_G0019365
protein coding gene Chr11:100216103-100216966 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0016996
protein coding gene Chr11:90712711-90713568 (+)
CAST/EiJ MGP_CASTEiJ_G0018281
protein coding gene Chr11:97022145-97023008 (+)
CBA/J MGP_CBAJ_G0018698
protein coding gene Chr11:104301263-104302117 (+)
DBA/2J MGP_DBA2J_G0018806
protein coding gene Chr11:92802386-92803249 (+)
FVB/NJ MGP_FVBNJ_G0018795
protein coding gene Chr11:92263864-92264727 (+)
LP/J MGP_LPJ_G0018876
protein coding gene Chr11:97712558-97713421 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0018822
protein coding gene Chr11:104361324-104362187 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0019405
protein coding gene Chr11:96365989-96366852 (+)
PWK/PhJ MGP_PWKPhJ_G0018052
protein coding gene Chr11:93709010-93709864 (+)
SPRET/EiJ MGP_SPRETEiJ_G0017841
protein coding gene Chr11:96052306-96053169 (+)
WSB/EiJ MGP_WSBEiJ_G0018330
protein coding gene Chr11:96292054-96292917 (+)



Homology
more
  • Human Ortholog
    H1-9P, H1.9 linker histone, pseudogene
  • Vertebrate Orthologs
    3
  • Human Ortholog
    H1-9P, H1.9 linker histone, pseudogene
    Orthology source: HGNC
  • Synonyms
    H1-9, H1.9, HILS1
  • Links
    NCBI Gene ID: 373861
    UniProt: P60008

  • Chr Location
    17q21.33; chr17:50171428-50172476 (-)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    7 phenotype references
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
  • cDNA Data
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 54388 NCBI Gene Model | MGI Sequence Detail 864 C57BL/6J ±  kb
transcript NM_018792 RefSeq | MGI Sequence Detail 864 C57BL/6  
polypeptide Q9QYL0 UniProt | EBI | MGI Sequence Detail 170 Not Applicable  
For the selected sequence
Protein
Information
less
  • UniProt
    2 Sequences
  • InterPro Domains
    IPR005818 Linker histone H1/H5, domain H15
    IPR036390 Winged helix DNA-binding domain superfamily
    IPR036388 Winged helix-like DNA-binding domain superfamily
Molecular
Reagents
less
  • All nucleic 34
    Genomic 2
    cDNA 32

    Microarray probesets 3
References
more
  • Summaries
    All 35
    Gene Ontology 4
    Phenotypes 7
  • Earliest
    J:49992 Duclos F, et al., Progressive muscular dystrophy in alpha-sarcoglycan-deficient mice. J Cell Biol. 1998 Sep 21;142(6):1461-71
  • Latest
    J:250931 Pan C, et al., Role of H1 linker histones in mammalian development and stem cell differentiation. Biochim Biophys Acta. 2016 Mar;1859(3):496-509

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources
Funding Information
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last database update
02/18/2020
MGI 6.14
The Jackson Laboratory