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Ddx49 Gene Detail
Summary
  • Symbol
    Ddx49
  • Name
    DEAD (Asp-Glu-Ala-Asp) box polypeptide 49
  • Synonyms
    R27090_2
  • Feature Type
    protein coding gene
  • IDs
    MGI:2136689
    NCBI Gene: 234374
Location & Maps
more
  • Sequence Map
    Chr8:70292866-70302489 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      9624 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 8, 34.15 cM
  • Mapping Data
    1 experiment
Homology
more
  • Human Ortholog
    DDX49, DEAD-box helicase 49
  • Vertebrate Orthologs
    10
  • Human Ortholog
    DDX49, DEAD-box helicase 49
    Orthology source: HomoloGene, HGNC
  • Synonyms
    R27090_2
  • Links
    NCBI Gene ID: 54555
    neXtProt AC: NX_Q9Y6V7

  • Chr Location
    19p12; chr19:18919675-18928633 (+)  GRCh38.p2

  • HomoloGene
    Vertebrate Homology Class 41308
    1 human;1 mouse;1 rat;1 chimpanzee;1 rhesus macaque;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed
  • HCOP
    human homology predictions: DDX49
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    7 phenotype references
  • All Mutations and Alleles
    6
  • Chemically induced (other)
    1
  • Gene trapped
    3
  • Targeted
    2
  • Genomic Mutations
    1 involving Ddx49
  • Incidental Mutations
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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  • cDNA Data
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000027333 VEGA Gene Model | MGI Sequence Detail 9624 C57BL/6J ±  kb
transcript OTTMUST00000067565 VEGA | MGI Sequence Detail 2137 Not Applicable  
polypeptide OTTMUSP00000034021 VEGA | MGI Sequence Detail 480 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    66 from dbSNP Build 142
Protein
Information
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  • UniProt
    2 Sequences
  • Protein Ontology
    PR:000032209 ATP-dependent RNA helicase DDX49
  • EC
  • InterPro Domains
    IPR000629 ATP-dependent RNA helicase DEAD-box, conserved site
    IPR011545 DEAD/DEAH box helicase domain
    IPR001650 Helicase, C-terminal
    IPR014001 Helicase superfamily 1/2, ATP-binding domain
    IPR027417 P-loop containing nucleoside triphosphate hydrolase
    IPR014014 RNA helicase, DEAD-box type, Q motif
Molecular
Reagents
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  • All nucleic 8
    Genomic 1
    cDNA 7

    Microarray probesets 4
References
more
  • Summaries
    All 26
    Gene Ontology 4
    Phenotypes 7
  • Earliest
    J:69829 Clarke D, et al., Comparative analysis of human 19p12-13 region in Fugu and mouse. Mamm Genome. 2001 Jun;12(6):478-83
  • Latest
    J:173534 Skarnes WC, et al., A conditional knockout resource for the genome-wide study of mouse gene function. Nature. 2011 Jun 16;474(7351):337-42

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/20/2016
MGI 6.05
The Jackson Laboratory