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Sarm1 Gene Detail
Summary
  • Symbol
    Sarm1
  • Name
    sterile alpha and HEAT/Armadillo motif containing 1
  • Synonyms
    A830091I15Rik, MyD88-5
  • Feature Type
    protein coding gene
  • IDs
    MGI:2136419
    NCBI Gene: 237868
  • Alliance
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr11:78472330-78497754 bp, - strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 11, 46.74 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    60 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2136419
protein coding gene Chr11:78472330-78497821 (-)
129S1/SvImJ MGP_129S1SvImJ_G0018781
protein coding gene Chr11:79485614-79516212 (-)
A/J MGP_AJ_G0018747
protein coding gene Chr11:76443030-76468842 (-)
AKR/J MGP_AKRJ_G0018717
protein coding gene Chr11:78745434-78772504 (-)
BALB/cJ MGP_BALBcJ_G0018721
protein coding gene Chr11:76846685-76871947 (-)
C3H/HeJ MGP_C3HHeJ_G0018534
protein coding gene Chr11:78793308-78819450 (-)
C57BL/6NJ MGP_C57BL6NJ_G0019172
protein coding gene Chr11:81956661-81985038 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0016807
protein coding gene Chr11:73413815-73438765 (-)
CAST/EiJ MGP_CASTEiJ_G0018088
protein coding gene Chr11:79249595-79276245 (-)
CBA/J MGP_CBAJ_G0018505
protein coding gene Chr11:85563865-85595046 (-)
DBA/2J MGP_DBA2J_G0018613
protein coding gene Chr11:76016251-76043531 (-)
FVB/NJ MGP_FVBNJ_G0018603
protein coding gene Chr11:75605232-75633773 (-)
LP/J MGP_LPJ_G0018684
protein coding gene Chr11:80003983-80031126 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0018629
protein coding gene Chr11:85930836-85956221 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0019212
protein coding gene Chr11:78994375-79020549 (-)
PWK/PhJ MGP_PWKPhJ_G0017859
protein coding gene Chr11:76814680-76839995 (-)
SPRET/EiJ MGP_SPRETEiJ_G0017650
protein coding gene Chr11:78605536-78637054 (-)
WSB/EiJ MGP_WSBEiJ_G0018141
protein coding gene Chr11:78823898-78849263 (-)



Homology
more
  • Human Ortholog
    SARM1, sterile alpha and TIR motif containing 1
  • Vertebrate Orthologs
    9
  • Human Ortholog
    SARM1, sterile alpha and TIR motif containing 1
    Orthology source: HGNC, HomoloGene
  • Synonyms
    MyD88-5, SAMD2, SARM
  • Links
    NCBI Gene ID: 23098
    neXtProt AC: NX_Q6SZW1
    UniProt: Q6SZW1

  • Chr Location
    17q11.2; chr17:28371662-28401045 (+)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 9015
    1 human;1 mouse;1 rat;1 chimpanzee;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: SARM1
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    10 phenotypes from 2 alleles in 2 genetic backgrounds
    22 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele exhibit reduced apoptosis induced by oxygen and glucose deprivation in hippocampal slices.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
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    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000050132 Ensembl Gene Model | MGI Sequence Detail 25425 C57BL/6J ±  kb
    transcript ENSMUST00000108287 Ensembl | MGI Sequence Detail 4868 Not Applicable  
    polypeptide ENSMUSP00000103922 Ensembl | MGI Sequence Detail 764 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      2 Sequences
    • Protein Ontology
      PR:000014458 sterile alpha and TIR motif-containing protein 1
    • InterPro Domains
      IPR011989 Armadillo-like helical
      IPR016024 Armadillo-type fold
      IPR039184 Sterile alpha and TIR motif-containing protein 1
      IPR001660 Sterile alpha motif domain
      IPR013761 Sterile alpha motif/pointed domain superfamily
      IPR000157 Toll/interleukin-1 receptor homology (TIR) domain
      IPR035897 Toll/interleukin-1 receptor homology (TIR) domain superfamily
    Molecular
    Reagents
    less
    • All nucleic 41
      cDNA 40
      Primer pair 1

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGI:2144643
    References
    more
    • Summaries
      All 55
      Developmental Gene Expression 4
      Gene Ontology 8
      Phenotypes 22
    • Earliest
      J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
    • Latest
      J:266573 Peters OM, et al., Loss of Sarm1 does not suppress motor neuron degeneration in the SOD1G93A mouse model of amyotrophic lateral sclerosis. Hum Mol Genet. 2018 Nov 1;27(21):3761-3771

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
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    last database update
    12/04/2018
    MGI 6.13
    The Jackson Laboratory