Hadhb
Gene Detail

Symbol Name ID

Hadhb hydroxyacyl-Coenzyme A dehydrogenase/3-ketoacyl-Coenzyme A thiolase/enoyl-Coenzyme A hydratase (trifunctional protein), beta subunit MGI:2136381

Synonyms

4930479F15Rik, Mtpb

Feature Type

protein coding gene

Genetic Map

Chromosome 5

16.04 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)

Sequence Map

Chr5:30155248-30184593 bp, + strand From VEGA annotation of GRCm38   29346 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:153  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: acetyl-CoA acetyltransferase
Gene Tree: Hadhb

Human homologs

Human Homolog		HADHB, hydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA thiolase/enoyl-CoA hydratase (trifunctional protein), beta subunit
NCBI Gene ID		3032
neXtProt AC		NX_P55084
Human Synonyms		ECHB, MTPB, TP-BETA
Human Chr (Location)		2p23; chr2:26467616-26513333 (+)  GRCh37.p10
Disease Associations		(1) Diseases Associated with Human HADHB

Alleles and phenotypes

All alleles(11) : Targeted(2) Gene trapped(8) Chemically induced(1)
 

Mice homozygous for an ENU-induced mutation display reduced postnatal weight gain, multifocal cardiac fibrosis and hepatic steatosis, and develop cardiac arrhythmias that range from a prolonged PR interval to complete atrioventricular dissociation and lead to sudden between 9 and 16 months of age.

 
Human Diseases Modeled Using Mouse Hadhb (1)    Alleles Annotated to Human Diseases(1)   

Gene Ontology (GO) classifications

All GO classifications: (34 annotations)

Process	fatty acid beta-oxidation, fatty acid metabolic process, ...
Component	endoplasmic reticulum, membrane, ...
Function	3-hydroxyacyl-CoA dehydrogenase activity, acetyl-CoA C-acyltransferase activity, ...

External Resources: FuncBase

Expression

Literature Summary: (1 records)
Data Summary: Results (11)    Tissues (4)    Images (2)
Theiler Stages: 26, 28

Assay Type	Results
Western blot	11

cDNA source data(14)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(15) cDNA(14) Primer pair(1)
Microarray probesets(6)

Other database links

VEGA Gene Model	OTTMUSG00000024744 (Evidence)
Ensembl Gene Model	ENSMUSG00000059447 (Evidence)
Entrez Gene	231086 (Evidence)
DFCI	TC1571973, TC1656752
DoTS	DT.101403284, DT.101739617, DT.102535103, DT.110694607, DT.40141306, DT.536652, DT.94280398
NIA Mouse Gene Index	U005412, U036718, U049689
EC	2.3.1.16
Consensus CDS Project	CCDS39045.1
International Mouse Knockout Project Status	Hadhb

Sequences

Length	Strain/Species
genomic	OTTMUSG00000024744	VEGA Gene Model | MGI Sequence Detail	29346	C57BL/6J
transcript	OTTMUST00000060920	VEGA | MGI Sequence Detail	2033	Not Applicable
polypeptide	OTTMUSP00000029777	VEGA | MGI Sequence Detail	475	Not Applicable

All sequences(59) RefSeq(2) UniProt(2)

Polymorphisms

SNPs(111 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR002155	Thiolase
InterPro	IPR020610	Thiolase, active site
InterPro	IPR020615	Thiolase, acyl-enzyme intermediate active site
InterPro	IPR020613	Thiolase, conserved site
InterPro	IPR020617	Thiolase, C-terminal
InterPro	IPR016039	Thiolase-like
InterPro	IPR016038	Thiolase-like, subgroup
InterPro	IPR020616	Thiolase, N-terminal
Protein Ontology	PR:000008434	trifunctional enzyme subunit beta, mitochondrial

References

(Earliest) J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
(Latest) J:173534 Skarnes WC, et al., A conditional knockout resource for the genome-wide study of mouse gene function. Nature. 2011 Jun 16;474(7351):337-42
All references(39)

Other accession IDs

MGI:1922043