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Hadhb
Gene Detail
 Symbol
Name
ID
Hadhb
hydroxyacyl-Coenzyme A dehydrogenase/3-ketoacyl-Coenzyme A thiolase/enoyl-Coenzyme A hydratase (trifunctional protein), beta subunit
MGI:2136381
Synonyms 4930479F15Rik, Mtpb
Feature Type protein coding gene
Genetic Map
Chromosome 5
16.04 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr5:30155248-30184593 bp, + strand
From VEGA annotation of GRCm38

  29346 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:153  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: acetyl-CoA acetyltransferase
Gene Tree: Hadhb

Human
homologs
Human Homolog HADHB, hydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA thiolase/enoyl-CoA hydratase (trifunctional protein), beta subunit
NCBI Gene ID 3032
neXtProt AC  NX_P55084
Human Synonyms  ECHB, MTPB, TP-BETA
Human Chr (Location)  2p23; chr2:26244748-26290465 (+)  GRCh38
Disease Associations  (1) Diseases Associated with Human HADHB
Mutations,
alleles, and
phenotypes
All mutations/alleles(14) : Chemically induced (ENU)(1) Gene trapped(8) Radiation induced(3) Targeted(2)
Genomic Mutations involving Hadhb (3)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for an ENU-induced mutation display reduced postnatal weight gain, multifocal cardiac fibrosis and hepatic steatosis, and develop cardiac arrhythmias that range from a prolonged PR interval to complete atrioventricular dissociation and lead to sudden between 9 and 16 months of age.
 
Human Diseases Modeled Using Mouse Hadhb (1)    Alleles Annotated to Human Diseases(2)   
Interactions
Hadhb interacts with 98 markers (Mir9-1, Mir9-2, Mir9-3, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (35 annotations)
Process fatty acid beta-oxidation, fatty acid metabolic process, ...
Component endoplasmic reticulum, extracellular vesicular exosome, ...
Function 3-hydroxyacyl-CoA dehydrogenase activity, acetyl-CoA C-acyltransferase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (1 records)
Data Summary: Results (11)    Tissues (4)    Images (2)
Theiler Stages: 26, 28
Assay TypeResults
Western blot 11
cDNA source data(14)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(15) cDNA(14) Primer pair(1)
Microarray probesets(6)
Other database
links
VEGA Gene ModelOTTMUSG00000024744 (Evidence)
Ensembl Gene ModelENSMUSG00000059447 (Evidence)
Entrez Gene231086 (Evidence)
DFCITC1571973, TC1656752
DoTSDT.101403284, DT.101739617, DT.102535103, DT.110694607, DT.40141306, DT.536652, DT.94246327, DT.94280398
NIA Mouse Gene IndexU005412, U036718, U049689
EC2.3.1.16
Consensus CDS ProjectCCDS39045.1
International Mouse Knockout Project StatusHadhb
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000024744 VEGA Gene Model | MGI Sequence Detail 29346 C57BL/6J ±  kb
transcript OTTMUST00000060920 VEGA | MGI Sequence Detail 2033 Not Applicable 
polypeptide OTTMUSP00000029777 VEGA | MGI Sequence Detail 475 Not Applicable 

For the selected sequences
All sequences(71) RefSeq(10) UniProt(2)
Polymorphisms SNPs within 2kb(115 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR002155 Thiolase
InterPro IPR020610 Thiolase, active site
InterPro IPR020615 Thiolase, acyl-enzyme intermediate active site
InterPro IPR020613 Thiolase, conserved site
InterPro IPR020617 Thiolase, C-terminal
InterPro IPR016039 Thiolase-like
InterPro IPR016038 Thiolase-like, subgroup
InterPro IPR020616 Thiolase, N-terminal
Protein Ontology PR:000008434 trifunctional enzyme subunit beta, mitochondrial
References (Earliest) J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
(Latest) J:173534 Skarnes WC, et al., A conditional knockout resource for the genome-wide study of mouse gene function. Nature. 2011 Jun 16;474(7351):337-42
All references(39)
Disease annotation references (1)
Other
accession IDs
MGI:1922043

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
08/19/2014
MGI 5.19
The Jackson Laboratory