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Lyve1 Gene Detail
Summary
  • Symbol
    Lyve1
  • Name
    lymphatic vessel endothelial hyaluronan receptor 1
  • Synonyms
    1200012G08Rik, lymphatic vessel endothelial HA receptor-1, Lyve-1, Xlkd1
  • Feature Type
    protein coding gene
  • IDs
    MGI:2136348
    NCBI Gene: 114332
  • Gene Overview
    MyGene.info: LYVE1
Location & Maps
more
  • Sequence Map
    Chr7:110850607-110863239 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      12633 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 7, 57.89 cM, cytoband F2
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    LYVE1, lymphatic vessel endothelial hyaluronan receptor 1
  • Vertebrate Orthologs
    10
  • Human Ortholog
    LYVE1, lymphatic vessel endothelial hyaluronan receptor 1
    Orthology source: HomoloGene, HGNC
  • Synonyms
    CRSBP-1, HAR, LYVE-1, XLKD1
  • Links
    NCBI Gene ID: 10894
    neXtProt AC: NX_Q9Y5Y7

  • Chr Location
    11p15; chr11:10557866-10568818 (-)  GRCh38.p2

  • HomoloGene
    Vertebrate Homology Class 4868
    1 human;1 mouse;1 rat;1 chimpanzee;1 rhesus macaque;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed
  • HCOP
    human homology predictions: LYVE1
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    3 phenotypes from 2 alleles in 2 genetic backgrounds
    9 phenotypes from multigenic genotypes
    22 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    8
  • Chemically induced (other)
    1
  • Radiation induced
    1
  • Targeted
    6
  • Genomic Mutations
    2 involving Lyve1
Mice homozygous for one allele display enlarged lymphatic vessels and increased interstitial-lymphatic flow. However, mice homozygous for a second allele do not display any abnormalities in the lymphatic system.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000060185 VEGA Gene Model | MGI Sequence Detail 12633 C57BL/6J ±  kb
transcript OTTMUST00000147311 VEGA | MGI Sequence Detail 2893 Not Applicable  
polypeptide OTTMUSP00000076671 VEGA | MGI Sequence Detail 318 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    130 from dbSNP Build 142
Protein
Information
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  • UniProt
    1 Sequence
  • Protein Ontology
    PR:000010012 lymphatic vessel endothelial hyaluronic acid receptor 1
  • InterPro Domains
    IPR016187 C-type lectin fold
    IPR016186 C-type lectin-like
    IPR000538 Link domain
Molecular
Reagents
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  • All nucleic 40
    cDNA 40

    Microarray probesets 5
Other
Accession IDs
less
MGI:1914711
References
more
  • Summaries
    All 195
    Developmental Gene Expression 153
    Gene Ontology 5
    Phenotypes 22
  • Earliest
    J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
  • Latest
    J:233304 Cha B, et al., Mechanotransduction activates canonical Wnt/beta-catenin signaling to promote lymphatic vascular patterning and the development of lymphatic and lymphovenous valves. Genes Dev. 2016 Jun 15;30(12):1454-69

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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Funding Information
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last database update
09/27/2016
MGI 6.05
The Jackson Laboratory