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Lyve1
Gene Detail
Symbol

Name
ID
Lyve1
lymphatic vessel endothelial hyaluronan receptor 1
MGI:2136348
Synonyms
1200012G08Rik, lymphatic vessel endothelial HA receptor-1, Lyve-1, Xlkd1
Feature Type
protein coding gene
Genetic Map
Chromosome 7
57.89 cM, cytoband F2
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr7:110850607-110862953 bp, - strand
From NCBI annotation of GRCm38

  12347 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:4868  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Gene Tree: Lyve1

Human
homologs
Human Homolog LYVE1, lymphatic vessel endothelial hyaluronan receptor 1
NCBI Gene ID 10894
neXtProt AC  NX_Q9Y5Y7
Human Synonyms  CRSBP-1, HAR, LYVE-1, XLKD1
Human Chr (Location)  11p15; chr11:10557866-10568818 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(6) : Targeted(6)
 
Mice homozygous for one allele display enlarged lymphatic vessels and increased interstitial-lymphatic flow. However, mice homozygous for a second allele do not display any abnormalities in the lymphatic system.
 
Interactions
Lyve1 interacts with 237 markers (Mir1a-1, Mir1a-2, Mir7-1, ...)
Gene Ontology
(GO)
classifications
Expression
Literature Summary: (116 records)
Data Summary: Results (451)    Tissues (106)    Images (228)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 323
RNA in situ 128
cDNA source data(40)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(40) cDNA(40)
Microarray probesets(5)
Other database
links
Ensembl Gene ModelENSMUSG00000030787 (Evidence)
Entrez Gene114332 (Evidence)
UniGene396078
DFCITC1579373
DoTSDT.532198
NIA Mouse Gene IndexU029123
Consensus CDS ProjectCCDS21748.1
International Mouse Knockout Project StatusLyve1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 114332 NCBI Gene Model | MGI Sequence Detail 12347 C57BL/6J ±  kb
transcript NM_053247 RefSeq | MGI Sequence Detail 2607 C57BL/6 
polypeptide Q8BHC0 UniProt | EBI | MGI Sequence Detail 318 Not Applicable 

For the selected sequences
All sequences(19) RefSeq(2) UniProt(1)
Polymorphisms
SNPs within 2kb(123 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR016187 C-type lectin fold
InterPro IPR016186 C-type lectin-like
InterPro IPR000538 Link
Protein Ontology PR:000010012 lymphatic vessel endothelial hyaluronic acid receptor 1
Graphical View of Protein Domain Structure
References
(Earliest) J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
(Latest) J:211806 Outeda P, et al., Polycystin signaling is required for directed endothelial cell migration and lymphatic development. Cell Rep. 2014 May 8;7(3):634-44
All references(158)
Other
accession IDs
MGI:1914711

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
11/11/2014
MGI 5.20
The Jackson Laboratory