About   Help   FAQ
Lyve1 Gene Detail
Summary
  • Symbol
    Lyve1
  • Name
    lymphatic vessel endothelial hyaluronan receptor 1
  • Synonyms
    1200012G08Rik, lymphatic vessel endothelial HA receptor-1, Lyve-1, Xlkd1
  • Feature Type
    protein coding gene
  • IDs
    MGI:2136348
    NCBI Gene: 114332
  • Alliance
    genome feature page
  • Transcription Start Sites
    7 TSS
Location &
Maps
more
  • Sequence Map
    Chr7:110449814-110462160 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 7, 57.89 cM, cytoband F2
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    354 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2136348
 protein coding gene Chr7:110449814-110462446 (-)
129S1/SvImJ ENSMUSG00200032771
 protein coding gene Chr7:96992802-97005437 (-)
A/J ENSMUSG00195031788
 protein coding gene Chr7:101487769-101500398 (-)
AKR/J ENSMUSG00220033421
 protein coding gene Chr7:94891308-94903938 (-)
BALB/cJ ENSMUSG00180037874
 protein coding gene Chr7:98164367-98177001 (-)
C3H/HeJ ENSMUSG00175049678
 protein coding gene Chr7:98800238-98812867 (-)
C57BL/6NJ ENSMUSG00215049188
 protein coding gene Chr7:98105050-98117683 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0030327
 protein coding gene Chr7:113132968-113145652 (-)
CAST/EiJ ENSTCUG00005043877
 protein coding gene Chr7:101483334-101495971 (-)
CBA/J ENSMUSG00210043091
 protein coding gene Chr7:98627282-98639914 (-)
DBA/2J ENSMUSG00185019950
 protein coding gene Chr7:102977431-102990064 (-)
FVB/NJ ENSMUSG00205047024
 protein coding gene Chr7:98589672-98602306 (-)
JF1/MsJ ENSUMUG00000037727
 protein coding gene Chr7:107995592-108008219 (-)
LP/J ENSMUSG00230044790
 protein coding gene Chr7:109078529-109091161 (-)
NOD/ShiLtJ ENSMUSG00190041997
 protein coding gene Chr7:98791542-98804157 (-)
NZO/HlLtJ ENSMUSG00225014355
 protein coding gene Chr7:107296111-107308737 (-)
PWK/PhJ ENSLUMG00010035756
 protein coding gene Chr7:97130095-97142728 (-)
SPRET/EiJ ENSMSPG00010039710
 protein coding gene Chr7:98293675-98305571 (-)
WSB/EiJ ENSIUOG00005044475
 protein coding gene Chr7:99439162-99451778 (-)



Homology
more
  • Human Ortholog
    LYVE1, lymphatic vessel endothelial hyaluronan receptor 1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    LYVE1, lymphatic vessel endothelial hyaluronan receptor 1
  • Synonyms
    CRSBP-1, HAR, LYVE-1, XLKD1
  • Links
    NCBI Gene ID: 10894
    UniProt: Q9Y5Y7

  • Chr Location
    11p15.4; chr11:10556966-10611689 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    3 phenotypes from 2 alleles in 2 genetic backgrounds
    9 phenotypes from multigenic genotypes
    2 images
    122 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for one allele display enlarged lymphatic vessels and increased interstitial-lymphatic flow. However, mice homozygous for a second allele do not display any abnormalities in the lymphatic system.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    30
  • GO References
    10
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1803
  • Tissues
    300
  • cDNA Data
    41
  • Literature Summary
    323
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 114332 NCBI Gene Model | MGI Sequence Detail 12347 C57BL/6J ±  kb
    transcript NM_053247 RefSeq | MGI Sequence Detail 2607 C57BL/6  
    polypeptide Q8BHC0 UniProt | EBI | MGI Sequence Detail 318 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 45
      cDNA 41
      Primer pair 4
      Antibodies 49

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGI:1914711
    References
    more
    • Summaries
      All 499
      Developmental Gene Expression 323
      Gene Ontology 10
      Phenotypes 122
    • Earliest
      J:88307 Giometti CS, et al., The analysis of recessive lethal mutations in mice by using two-dimensional gel electrophoresis of liver proteins. Mutat Res. 1990 Sep;242(1):47-55
    • Latest
      J:391718 Han J, et al., Two differentiation pathways generate large peritoneal macrophages with one replenishing mesothelial border macrophages. Sci Immunol. 2026 Jul 31;11(121):eaeg8653
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
    Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
    Send questions and comments to User Support.     		last database update
    09/01/2026
    MGI 6.24     		The Jackson Laboratory