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Lyve1
Gene Detail
Symbol

Name
ID
Lyve1
lymphatic vessel endothelial hyaluronan receptor 1
MGI:2136348
Synonyms
1200012G08Rik, lymphatic vessel endothelial HA receptor-1, Lyve-1, Xlkd1
Feature Type
protein coding gene
Genetic Map
Chromosome 7
57.89 cM, cytoband F2
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr7:110850607-110862953 bp, - strand
From NCBI annotation of GRCm38

  12347 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:4868  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: LYVE1
Gene Tree: Lyve1

Human
homologs
LYVE1, lymphatic vessel endothelial hyaluronan receptor 1
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 10894
neXtProt AC: NX_Q9Y5Y7

Human Synonyms: CRSBP-1, HAR, LYVE-1, XLKD1

Human Chr (Location): 11p15; chr11:10557866-10568818 (-)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(6) : Targeted(6)
 
Mice homozygous for one allele display enlarged lymphatic vessels and increased interstitial-lymphatic flow. However, mice homozygous for a second allele do not display any abnormalities in the lymphatic system.
 
Interactions
Lyve1 interacts with 236 markers (Mir1a-1, Mir1a-2, Mir7-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (11 annotations)
Process cell adhesion, glycosaminoglycan catabolic process, ...
Component cell periphery, extracellular exosome, ...
Function hyaluronic acid binding, transmembrane signaling receptor activity
External Resources: FuncBase
Expression
Literature Summary: (137 records)
Data Summary: Results (474)    Tissues (115)    Images (228)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 346
RNA in situ 128
cDNA source data(40)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase lyve1 ; ZFIN lyve1a, lyve1b    NEW 
Molecular
reagents
All nucleic(40) cDNA(40)
Microarray probesets(5)
Other database
links
Ensembl Gene Model ENSMUSG00000030787 (Evidence)
Entrez Gene 114332 (Evidence)
UniGene 396078
DFCI TC1579373
DoTS DT.532198
NIA Mouse Gene Index U029123
Consensus CDS Project CCDS21748.1
International Mouse Phenotyping Consortium Status Lyve1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 114332 NCBI Gene Model | MGI Sequence Detail 12347 C57BL/6J ±  kb
transcript NM_053247 RefSeq | MGI Sequence Detail 2607 C57BL/6 
polypeptide Q8BHC0 UniProt | EBI | MGI Sequence Detail 318 Not Applicable 

For the selected sequences
All sequences(19) RefSeq(2) UniProt(1)
Polymorphisms
SNPs within 2kb(123 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR016187 C-type lectin fold
InterPro IPR016186 C-type lectin-like
InterPro IPR000538 Link domain
Protein Ontology PR:000010012 lymphatic vessel endothelial hyaluronic acid receptor 1
Graphical View of Protein Domain Structure
References
(Earliest) J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
(Latest) J:222732 Rouhani SJ, et al., Roles of lymphatic endothelial cells expressing peripheral tissue antigens in CD4 T-cell tolerance induction. Nat Commun. 2015;6:6771
All references(179)
Other
accession IDs
MGI:1914711

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/25/2015
MGI 6.0
The Jackson Laboratory