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Wnt16 Gene Detail
Summary
  • Symbol
    Wnt16
  • Name
    wingless-type MMTV integration site family, member 16
  • Synonyms
    E130309I19Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:2136018
    NCBI Gene: 93735
  • Gene Overview
    MyGene.info: WNT16
  • Alliance
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr6:22288227-22298522 bp, + strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 6, 9.22 cM, cytoband A3
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    139 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2136018
protein coding gene Chr6:22288168-22298522 (.)
129S1/SvImJ MGP_129S1SvImJ_G0030483
protein coding gene Chr6:19789698-19800326 (+)
A/J MGP_AJ_G0030456
protein coding gene Chr6:18971840-18982125 (+)
AKR/J MGP_AKRJ_G0030383
protein coding gene Chr6:19575945-19586225 (+)
BALB/cJ MGP_BALBcJ_G0030465
protein coding gene Chr6:19050633-19061497 (+)
C3H/HeJ MGP_C3HHeJ_G0030179
protein coding gene Chr6:19523107-19533404 (+)
C57BL/6NJ MGP_C57BL6NJ_G0030920
protein coding gene Chr6:20385802-20396098 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0028131
protein coding gene Chr6:17573734-17583980 (+)
CAST/EiJ MGP_CASTEiJ_G0029581
protein coding gene Chr6:19466817-19477210 (+)
CBA/J MGP_CBAJ_G0030157
protein coding gene Chr6:21067763-21078058 (+)
DBA/2J MGP_DBA2J_G0030301
protein coding gene Chr6:18876020-18886312 (+)
FVB/NJ MGP_FVBNJ_G0030255
protein coding gene Chr6:18671788-18682070 (+)
LP/J MGP_LPJ_G0030388
protein coding gene Chr6:19901850-19912191 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0030291
protein coding gene Chr6:22895400-22905503 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0030950
protein coding gene Chr6:19532984-19543271 (+)
PWK/PhJ MGP_PWKPhJ_G0029295
protein coding gene Chr6:18554698-18565071 (+)
SPRET/EiJ MGP_SPRETEiJ_G0029131
protein coding gene Chr6:19273541-19283783 (+)
WSB/EiJ MGP_WSBEiJ_G0029657
protein coding gene Chr6:19422987-19433538 (+)



Homology
more
  • Human Ortholog
    WNT16, Wnt family member 16
  • Vertebrate Orthologs
    9
  • Human Ortholog
    WNT16, Wnt family member 16
    Orthology source: HomoloGene, HGNC
  • Links
    NCBI Gene ID: 51384
    neXtProt AC: NX_Q9UBV4
    UniProt: Q9UBV4

  • Chr Location
    7q31.31; chr7:121325367-121341104 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    4 phenotypes from 1 allele in 1 genetic background
    11 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit decreased bone mineral density, cortical bone thickness and bone strength.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000029671 Ensembl Gene Model | MGI Sequence Detail 10296 C57BL/6J ±  kb
    transcript ENSMUST00000031681 Ensembl | MGI Sequence Detail 1663 Not Applicable  
    polypeptide ENSMUSP00000031681 Ensembl | MGI Sequence Detail 364 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 20
      Genomic 1
      cDNA 12
      Primer pair 5
      Other 2

      Microarray probesets 2
    Other
    Accession IDs
    less
    MGI:2444753
    References
    more
    • Summaries
      All 74
      Developmental Gene Expression 40
      Gene Ontology 7
      Phenotypes 11
    • Earliest
      J:57926 McWhirter JR, et al., Oncogenic homeodomain transcription factor E2A-Pbx1 activates a novel WNT gene in pre-B acute lymphoblastoid leukemia. Proc Natl Acad Sci U S A. 1999 Sep 28;96(20):11464-9
    • Latest
      J:253067 Sigal M, et al., Stromal R-spondin orchestrates gastric epithelial stem cells and gland homeostasis. Nature. 2017 Aug 24;548(7668):451-455

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
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    last database update
    11/06/2018
    MGI 6.13
    The Jackson Laboratory