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Wnt16
Gene Detail
Symbol

Name
ID
Wnt16
wingless-type MMTV integration site family, member 16
MGI:2136018
Synonyms
E130309I19Rik
Feature Type
protein coding gene
Genetic Map
Chromosome 6
9.22 cM, cytoband A3
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr6:22288227-22298522 bp, + strand
From VEGA annotation of GRCm38

  10296 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:62175  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: WNT16
Protein SuperFamily: int-1 transforming protein
Gene Tree: Wnt16

Human
homologs
WNT16, wingless-type MMTV integration site family, member 16
Orthology source: HomoloGene, HGNC

IDs:
NCBI Gene ID: 51384
neXtProt AC: NX_Q9UBV4

Human Chr (Location): 7q31; chr7:121325367-121341104 (+)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(5) : Targeted(5)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a knock-out allele exhibit decreased bone mineral density, cortical bone thickness and bone strength.
 
Interactions
Wnt16 interacts with 313 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (23 annotations)
Process bone remodeling, cardiac epithelial to mesenchymal transition, ...
Component cytoplasm, extracellular region, ...
Function frizzled binding, receptor binding
This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase
Expression
Literature Summary: (33 records)
Data Summary: Results (380)    Tissues (355)    Images (27)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 358
Northern blot 4
RT-PCR 18
cDNA source data(11)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: GEISHA WNT16 ; Xenbase wnt16 ; ZFIN wnt16    NEW 
Molecular
reagents
All nucleic(18) Genomic(1) cDNA(11) Primer pair(5) Other(1)
Microarray probesets(2)
Other database
links
VEGA Gene Model OTTMUSG00000026889 (Evidence)
Ensembl Gene Model ENSMUSG00000029671 (Evidence)
Entrez Gene 93735 (Evidence)
UniGene 137403
DFCI TC1610123, TC1590558
DoTS DT.101716642, DT.91581325, DT.94155881
NIA Mouse Gene Index U006585
Consensus CDS Project CCDS19936.1
International Mouse Phenotyping Consortium Status Wnt16
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000026889 VEGA Gene Model | MGI Sequence Detail 10296 C57BL/6J ±  kb
transcript OTTMUST00000066501 VEGA | MGI Sequence Detail 1663 Not Applicable 
polypeptide OTTMUSP00000033330 VEGA | MGI Sequence Detail 364 Not Applicable 

For the selected sequences
All sequences(41) RefSeq(4) UniProt(5)
Polymorphisms
SNPs within 2kb(138 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR005817 Wnt
InterPro IPR013304 Wnt-16 protein
InterPro IPR018161 Wnt protein, conserved site
Protein Ontology PR:000017439 protein Wnt-16
References
(Earliest) J:57926 McWhirter JR, et al., Oncogenic homeodomain transcription factor E2A-Pbx1 activates a novel WNT gene in pre-B acute lymphoblastoid leukemia. Proc Natl Acad Sci U S A. 1999 Sep 28;96(20):11464-9
(Latest) J:221507 Wergedal JE, et al., Role of WNT16 in the regulation of periosteal bone formation in female mice. Endocrinology. 2015 Mar;156(3):1023-32
All references(62)
Other
accession IDs
MGI:2444753

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
06/30/2015
MGI 5.22
The Jackson Laboratory