Wnt16
Gene Detail

Symbol Name ID

Wnt16 wingless-related MMTV integration site 16 MGI:2136018

Synonyms

E130309I19Rik

Feature Type

protein coding gene

Genetic Map

Chromosome 6

9.22 cM, cytoband A3
Detailed Genetic Map ± 1 cM


Mapping data(2)

Sequence Map

Chr6:22288227-22298522 bp, + strand From VEGA annotation of GRCm38   10296 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:62175  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 chicken; 1 zebrafish

Protein SuperFamily: int-1 transforming protein
Gene Tree: Wnt16

Human homologs

Human Homolog		WNT16, wingless-type MMTV integration site family, member 16
NCBI Gene ID		51384
neXtProt AC		NX_Q9UBV4
Human Chr (Location)		7q31; chr7:120965421-120981158 (+)  GRCh37.p10

Alleles and phenotypes

All alleles(4) : Targeted(4)
 

Mice homozygous for a knock-out allele exhibit decreased bone mineral density, cortical bone thickness and bone strength.

 

Gene Ontology (GO) classifications

All GO classifications: (22 annotations)

Process	cardiac epithelial to mesenchymal transition, cell fate commitment, ...
Component	cytoplasm, extracellular region, ...
Function	frizzled binding, receptor binding

This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase

Expression

Literature Summary: (30 records)
Data Summary: Results (205)    Tissues (181)    Images (22)
Theiler Stages: 1, 2, 3, 4, 5, 8, 9, 10, 11, 13, 15, 17, 18, 19, 20, 21, 22, 23, 25, 28

Assay Type	Results
RNA in situ	179
Northern blot	4
RT-PCR	22

cDNA source data(10)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(17) Genomic(1) cDNA(10) Primer pair(5) Other(1)
Microarray probesets(2)

Other database links

VEGA Gene Model	OTTMUSG00000026889 (Evidence)
Ensembl Gene Model	ENSMUSG00000029671 (Evidence)
Entrez Gene	93735 (Evidence)
UniGene	137403
DFCI	TC1590558, TC1610123
DoTS	DT.101716642, DT.91581325, DT.94155881
NIA Mouse Gene Index	U006585
Consensus CDS Project	CCDS19936.1
International Mouse Knockout Project Status	Wnt16

Sequences

Length	Strain/Species
genomic	OTTMUSG00000026889	VEGA Gene Model | MGI Sequence Detail	10296	C57BL/6J
transcript	OTTMUST00000066501	VEGA | MGI Sequence Detail	1663	Not Applicable
polypeptide	OTTMUSP00000033330	VEGA | MGI Sequence Detail	364	Not Applicable

All sequences(39) RefSeq(2) UniProt(5)

Polymorphisms

SNPs(77 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR005817	Wnt
InterPro	IPR013304	Wnt-16 protein
InterPro	IPR018161	Wnt protein, conserved site
Protein Ontology	PR:000017439	protein Wnt-16

References

(Earliest) J:57926 McWhirter JR, et al., Oncogenic homeodomain transcription factor E2A-Pbx1 activates a novel WNT gene in pre-B acute lymphoblastoid leukemia. Proc Natl Acad Sci U S A. 1999 Sep 28;96(20):11464-9
(Latest) J:194035 Kan A, et al., c-Jun is required for the specification of joint cell fates. Genes Dev. 2013 Mar 1;27(5):514-24
All references(57)

Other accession IDs

MGI:2444753