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Prlhr Gene Detail
Summary
  • Symbol
    Prlhr
  • Name
    prolactin releasing hormone receptor
  • Synonyms
    Gpr10, GR3, LOC226278, PrRPR
  • Feature Type
    protein coding gene
  • IDs
    MGI:2135956
    NCBI Gene: 226278
Location & Maps
more
  • Sequence Map
    Chr19:60466733-60468304 bp, - strand
  • From Ensembl annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      1572 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 19, 56.52 cM
  • Mapping Data
    1 experiment
Homology
more
  • Human Ortholog
    PRLHR, prolactin releasing hormone receptor
  • Vertebrate Orthologs
    8
  • Human Ortholog
    PRLHR, prolactin releasing hormone receptor
    Orthology source: HomoloGene
  • Synonyms
    GPR10, GR3, PrRPR
  • Links
    NCBI Gene ID: 2834
    neXtProt AC: NX_P49683

  • Chr Location
    10q26.13; chr10:118591925-118599895 (-)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    21 phenotypes from 3 alleles in 3 genetic backgrounds
    4 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    3
  • Targeted
    3
  • Incidental Mutations
    APF
Mice homozygous for disruptions in this gene ate more than normal and became obese as they aged.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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  • cDNA Data
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000045052 Ensembl Gene Model | MGI Sequence Detail 1572 C57BL/6J ±  kb
transcript ENSMUST00000051277 Ensembl | MGI Sequence Detail 1572 Not Applicable  
polypeptide ENSMUSP00000063114 Ensembl | MGI Sequence Detail 370 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    48 from dbSNP Build 142
Protein
Information
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  • UniProt
    1 Sequence
  • Protein Ontology
    PR:000001546 prolactin-releasing peptide receptor
  • InterPro Domains
    IPR017452 GPCR, rhodopsin-like, 7TM
    IPR000276 G protein-coupled receptor, rhodopsin-like
    IPR001402 Prolactin-releasing peptide receptor
Molecular
Reagents
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  • All nucleic 4
    cDNA 4

    Microarray probesets 1
Other
Accession IDs
less
MGI:2685185
References
more
  • Summaries
    All 24
    Gene Ontology 5
    Phenotypes 4
  • Earliest
    J:90533 Gu W, et al., The prolactin-releasing peptide receptor (GPR10) regulates body weight homeostasis in mice. J Mol Neurosci. 2004;22(1-2):93-103
  • Latest
    J:153498 Diez-Roux G, et al., A high-resolution anatomical atlas of the transcriptome in the mouse embryo. PLoS Biol. 2011;9(1):e1000582

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
06/22/2016
MGI 6.04
The Jackson Laboratory