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Nkd1 Gene Detail
Summary
  • Symbol
    Nkd1
  • Name
    naked cuticle 1
  • Synonyms
    2810434J10Rik, 9030215G15Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:2135954
    NCBI Gene: 93960
  • Alliance
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr8:88521354-88594884 bp, + strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 8, 43.36 cM, cytoband C4
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    712 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2135954
protein coding gene Chr8:88521344-88594887 (+)
129S1/SvImJ MGP_129S1SvImJ_G0033920
protein coding gene Chr8:89605483-89685293 (+)
A/J MGP_AJ_G0033903
protein coding gene Chr8:86086279-86157493 (+)
AKR/J MGP_AKRJ_G0033829
protein coding gene Chr8:88615992-88701892 (+)
BALB/cJ MGP_BALBcJ_G0033896
protein coding gene Chr8:86242560-86318797 (+)
C3H/HeJ MGP_C3HHeJ_G0033606
protein coding gene Chr8:89222766-89295057 (+)
C57BL/6NJ MGP_C57BL6NJ_G0034416
protein coding gene Chr8:92990901-93064602 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0031358
protein coding gene Chr8:80056173-80129709 (+)
CAST/EiJ MGP_CASTEiJ_G0032937
protein coding gene Chr8:88658950-88740849 (+)
CBA/J MGP_CBAJ_G0033582
protein coding gene Chr8:96135604-96214799 (+)
DBA/2J MGP_DBA2J_G0033735
protein coding gene Chr8:85672391-85748647 (+)
FVB/NJ MGP_FVBNJ_G0033682
protein coding gene Chr8:84631637-84712595 (+)
LP/J MGP_LPJ_G0033827
protein coding gene Chr8:89724830-89804750 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0033725
protein coding gene Chr8:98588955-98669143 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0034435
protein coding gene Chr8:88630602-88709007 (+)
PWK/PhJ MGP_PWKPhJ_G0032640
protein coding gene Chr8:84946625-85021975 (+)
SPRET/EiJ MGP_SPRETEiJ_G0032476
protein coding gene Chr8:87435144-87514318 (+)
WSB/EiJ MGP_WSBEiJ_G0033048
protein coding gene Chr8:89078087-89161832 (+)



Homology
more
  • Human Ortholog
    NKD1, NKD inhibitor of WNT signaling pathway 1
  • Vertebrate Orthologs
    10
  • Human Ortholog
    NKD1, NKD inhibitor of WNT signaling pathway 1
    Orthology source: HomoloGene, HGNC
  • Synonyms
    Naked1
  • Links
    NCBI Gene ID: 85407
    neXtProt AC: NX_Q969G9
    UniProt: Q969G9

  • Chr Location
    16q12.1; chr16:50548330-50649249 (+)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 12343
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: NKD1
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    11 phenotypes from 2 alleles in 3 genetic backgrounds
    5 phenotypes from multigenic genotypes
    29 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygous null mice display reduced male fertility with oligozoospermia, small testis, and small seminiferous tubules.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000031661 Ensembl Gene Model | MGI Sequence Detail 73531 C57BL/6J ±  kb
    transcript ENSMUST00000034086 Ensembl | MGI Sequence Detail 3035 Not Applicable  
    polypeptide ENSMUSP00000034086 Ensembl | MGI Sequence Detail 471 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 56
      cDNA 47
      Primer pair 7
      Other 2

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGI:1917223, MGI:1924913
    References
    more
    • Summaries
      All 75
      Developmental Gene Expression 24
      Gene Ontology 8
      Phenotypes 29
    • Earliest
      J:13049 Gruneberg H, Genetical studies on the skeleton of the mouse. XVIII. Three genes for syndactylism. J Genet. 1956;54:113-145
    • Latest
      J:266142 Grosjean F, et al., Pharmacologic control of oxidative stress and inflammation determines whether diabetic glomerulosclerosis progresses or decreases: A pilot study in sclerosis-prone mice. PLoS One. 2018;13(9):e0204366

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    03/13/2019
    MGI 6.13
    The Jackson Laboratory