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Nkd1 Gene Detail
Summary
  • Symbol
    Nkd1
  • Name
    naked cuticle 1 homolog (Drosophila)
  • Synonyms
    2810434J10Rik, 9030215G15Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:2135954
    NCBI Gene: 93960
Location & Maps
more
  • Sequence Map
    Chr8:88521344-88594887 bp, + strand
  • From NCBI annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      73544 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 8, 43.36 cM, cytoband C4
  • Detailed Genetic Map ± 1 cM
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    NKD1, naked cuticle homolog 1
  • Vertebrate Orthologs
    10
  • Human Ortholog
    NKD1, naked cuticle homolog 1
    Orthology source: HomoloGene
  • Synonyms
    Naked1
  • Links
    NCBI Gene ID: 85407
    neXtProt AC: NX_Q969G9

  • Chr Location
    16q12.1; chr16:50548330-50649249 (+)  GRCh38.p2

  • HomoloGene
    Vertebrate Homology Class 12343
    1 human;1 mouse;1 rat;1 chimpanzee;1 rhesus macaque;1 cattle;1 dog;1 chicken;1 western clawed frog;1 zebrafish
  • HCOP
    human homology predictions: NKD1
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    11 phenotypes from 2 alleles in 3 genetic backgrounds
    5 phenotypes from multigenic genotypes
    28 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryogenesis
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
tumorigenesis
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    5
  • Radiation induced
    1
  • Targeted
    4
  • Genomic Mutations
    1 involving Nkd1
  • Incidental Mutations
Homozygous null mice display reduced male fertility with oligozoospermia, small testis, and small seminiferous tubules.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 93960 NCBI Gene Model | MGI Sequence Detail 73544 C57BL/6J ±  kb
transcript NM_027280 RefSeq | MGI Sequence Detail 4314 C57BL/6  
polypeptide Q99MH6 UniProt | EBI | MGI Sequence Detail 471 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    712 from dbSNP Build 142
Protein
Information
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Molecular
Reagents
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  • All nucleic 49
    cDNA 44
    Primer pair 5

    Microarray probesets 4
Other
Accession IDs
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MGI:1917223, MGI:1924913
References
more
  • Summaries
    All 41
    Developmental Gene Expression 18
    Gene Ontology 7
    Phenotypes 28
  • Earliest
    J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
  • Latest
    J:221338 Hammond E, et al., The Wnt effector transcription factor 7-like 2 positively regulates oligodendrocyte differentiation in a manner independent of Wnt/beta-catenin signaling. J Neurosci. 2015 Mar 25;35(12):5007-22

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
05/24/2016
MGI 6.04
The Jackson Laboratory