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Cd163 Gene Detail
Summary
  • Symbol
    Cd163
  • Name
    CD163 antigen
  • Feature Type
    protein coding gene
  • IDs
    MGI:2135946
    NCBI Gene: 93671
  • Gene Overview
    MyGene.info: CD163
  • Alliance
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr6:124304656-124330527 bp, + strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 6, 59.13 cM, cytoband F2
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    68 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2135946
protein coding gene Chr6:124304630-124330529 (.)
129S1/SvImJ MGP_129S1SvImJ_G0031254
protein coding gene Chr6:127564146-127590362 (+)
A/J MGP_AJ_G0031221
protein coding gene Chr6:122695938-122722464 (+)
AKR/J MGP_AKRJ_G0031149
protein coding gene Chr6:126080447-126105921 (+)
BALB/cJ MGP_BALBcJ_G0031229
protein coding gene Chr6:122329068-122356444 (+)
C3H/HeJ MGP_C3HHeJ_G0030952
protein coding gene Chr6:126138849-126164315 (+)
C57BL/6NJ MGP_C57BL6NJ_G0031687
protein coding gene Chr6:130865476-130893669 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0028839
protein coding gene Chr6:120004705-120030891 (+)
CAST/EiJ MGP_CASTEiJ_G0030335
protein coding gene Chr6:126390886-126419424 (+)
CBA/J MGP_CBAJ_G0030911
protein coding gene Chr6:136020116-136045849 (+)
DBA/2J MGP_DBA2J_G0031067
protein coding gene Chr6:121621340-121648035 (+)
FVB/NJ MGP_FVBNJ_G0031017
protein coding gene Chr6:120570373-120597603 (+)
LP/J MGP_LPJ_G0031148
protein coding gene Chr6:127770118-127796493 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0031055
protein coding gene Chr6:139992904-140030296 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0031718
protein coding gene Chr6:125983073-126009567 (+)
PWK/PhJ MGP_PWKPhJ_G0030049
protein coding gene Chr6:119884454-119910989 (+)
SPRET/EiJ MGP_SPRETEiJ_G0029878
protein coding gene Chr6:124118547-124144043 (+)
WSB/EiJ MGP_WSBEiJ_G0030417
protein coding gene Chr6:126334352-126360672 (+)



Homology
more
  • Human Ortholog
    CD163, CD163 molecule
  • Vertebrate Orthologs
    7
  • Human Ortholog
    CD163, CD163 molecule
    Orthology source: HomoloGene, HGNC
  • Synonyms
    M130, MM130, SCARI1
  • Links
    NCBI Gene ID: 9332
    neXtProt AC: NX_Q86VB7
    UniProt: Q86VB7

  • Chr Location
    12p13.31; chr12:7470816-7503818 (-)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    10 phenotypes from 1 allele in 1 genetic background
    8 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
After hindlimb ischemia, mice homozygous for a knock-out allele exhibit increased muscle satellite cell proliferation, and enhanced skeletal muscle regeneration not limited to the site of injury. Knock-out mice also exhibit increased eosinophilic airway inflammation in house dust mite-challenged.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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  • cDNA Data
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000008845 Ensembl Gene Model | MGI Sequence Detail 25872 C57BL/6J ±  kb
transcript ENSMUST00000112541 Ensembl | MGI Sequence Detail 4443 Not Applicable  
polypeptide ENSMUSP00000108160 Ensembl | MGI Sequence Detail 1159 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
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  • All nucleic 8
    Genomic 2
    cDNA 6

    Microarray probesets 3
References
more
  • Summaries
    All 33
    Gene Ontology 6
    Phenotypes 8
  • Earliest
    J:68977 Schaer DJ, et al., Molecular cloning and characterization of the mouse CD163 homologue, a highly glucocorticoid-inducible member of the scavenger receptor cysteine-rich family. Immunogenetics. 2001 Mar;53(2):170-7
  • Latest
    J:260793 Guo L, et al., CD163+ macrophages promote angiogenesis and vascular permeability accompanied by inflammation in atherosclerosis. J Clin Invest. 2018 Mar 1;128(3):1106-1124

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/06/2018
MGI 6.13
The Jackson Laboratory