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Cpn1
Gene Detail
Symbol

Name
ID
Cpn1
carboxypeptidase N, polypeptide 1
MGI:2135874
Synonyms
0610011F20Rik, 50 kDa, CPN
Feature Type
protein coding gene
Genetic Map
Chromosome 19
36.68 cM, cytoband D2
Detailed Genetic Map ± 1 cM


Mapping data(5)
Sequence Map
Chr19:43956307-43986556 bp, - strand
From VEGA annotation of GRCm38

  30250 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:1002  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: CPN1
Protein SuperFamily: carboxypeptidase, M type
Gene Tree: Cpn1

Human
homologs
CPN1, carboxypeptidase N, polypeptide 1
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 1369
neXtProt AC: NX_P15169

Human Synonyms: CPN, SCPN

Human Chr (Location): 10q24.2; chr10:100042308-100081901 (-)  GRCh38.p2

Disease Associations: (1) Diseases Associated with Human CPN1

Mutations,
alleles, and
phenotypes
All mutations/alleles(3) : Targeted(3)
Incidental mutations (data from APF , CvDC )
 
Homozygous null mice are more susceptible to anaphylactic shock caused by complement activating factors.
 
Interactions
Cpn1 interacts with 37 markers (Mir10b, Mir30c-1, Mir30c-2, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (14 annotations)
Process bradykinin catabolic process, proteolysis, ...
Component extracellular region, extracellular space
Function carboxypeptidase activity, hydrolase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (8 records)
Data Summary: Results (61)    Tissues (16)    Images (31)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 61
cDNA source data(52)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase cpn1 ; ZFIN cpn1    NEW 
Molecular
reagents
All nucleic(55) Genomic(1) cDNA(52) Primer pair(2)
Microarray probesets(5)
Other database
links
VEGA Gene Model OTTMUSG00000026385 (Evidence)
Ensembl Gene Model ENSMUSG00000025196 (Evidence)
Entrez Gene 93721 (Evidence)
UniGene 206774
DFCI TC1580282, TC1608553
DoTS DT.40166702, DT.487171
NIA Mouse Gene Index U039067
EC 3.4.17.3
Consensus CDS Project CCDS29840.1
International Mouse Phenotyping Consortium Status Cpn1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000026385 VEGA Gene Model | MGI Sequence Detail 30250 C57BL/6J ±  kb
transcript OTTMUST00000065251 VEGA | MGI Sequence Detail 1828 Not Applicable 
polypeptide OTTMUSP00000032496 VEGA | MGI Sequence Detail 457 Not Applicable 

For the selected sequences
All sequences(29) RefSeq(4) UniProt(1)
Polymorphisms
SNPs within 2kb(371 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR008969 Carboxypeptidase-like, regulatory domain
InterPro IPR027063 Carboxypeptidase N catalytic chain
InterPro IPR014766 Carboxypeptidase, regulatory domain
InterPro IPR000834 Peptidase M14, carboxypeptidase A
Protein Ontology PR:000005814 carboxypeptidase N catalytic chain
References
(Earliest) J:68326 Sato T, et al., Pro-carboxypeptidase R is an acute phase protein in the mouse, whereas carboxypeptidase N is not. J Immunol. 2000 Jul 15;165(2):1053-8
(Latest) J:173534 Skarnes WC, et al., A conditional knockout resource for the genome-wide study of mouse gene function. Nature. 2011 Jun 16;474(7351):337-42
All references(41)
Other
accession IDs
MGI:1923506

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
08/18/2015
MGI 6.0
The Jackson Laboratory