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Cpn1 Gene Detail
Summary
  • Symbol
    Cpn1
  • Name
    carboxypeptidase N, polypeptide 1
  • Synonyms
    0610011F20Rik, 50 kDa, CPN
  • Feature Type
    protein coding gene
  • IDs
    MGI:2135874
    NCBI Gene: 93721
  • Gene Overview
    MyGene.info: CPN1
  • Alliance
  • Transcription Start Sites
    13 TSS
Location &
Maps
more
  • Sequence Map
    Chr19:43956307-43986551 bp, - strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 19, 36.68 cM, cytoband D2
  • Mapping Data
    5 experiments
Strain
Comparison
more
  • SNPs within 2kb
    368 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2135874
protein coding gene Chr19:43956307-43986556 (-)
129S1/SvImJ MGP_129S1SvImJ_G0025160
protein coding gene Chr19:43394158-43431747 (-)
A/J MGP_AJ_G0025137
protein coding gene Chr19:41329290-41361032 (-)
AKR/J MGP_AKRJ_G0025105
protein coding gene Chr19:42629849-42665007 (-)
BALB/cJ MGP_BALBcJ_G0025131
protein coding gene Chr19:41374653-41406120 (-)
C3H/HeJ MGP_C3HHeJ_G0024891
protein coding gene Chr19:42806524-42842636 (-)
C57BL/6NJ MGP_C57BL6NJ_G0025574
protein coding gene Chr19:44457152-44489827 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0022988
protein coding gene Chr19:40623391-40654510 (-)
CAST/EiJ MGP_CASTEiJ_G0024356
protein coding gene Chr19:42509310-42541020 (-)
CBA/J MGP_CBAJ_G0024871
protein coding gene Chr19:46666157-46700615 (-)
DBA/2J MGP_DBA2J_G0025003
protein coding gene Chr19:41154745-41185285 (-)
FVB/NJ MGP_FVBNJ_G0024964
protein coding gene Chr19:40905220-40950584 (-)
LP/J MGP_LPJ_G0025089
protein coding gene Chr19:43354886-43388070 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0024995
protein coding gene Chr19:46196315-46231608 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0025632
protein coding gene Chr19:42720812-42757170 (-)
PWK/PhJ MGP_PWKPhJ_G0024105
protein coding gene Chr19:41052935-41084706 (-)
SPRET/EiJ MGP_SPRETEiJ_G0023909
protein coding gene Chr19:41437319-41471032 (-)
WSB/EiJ MGP_WSBEiJ_G0024426
protein coding gene Chr19:42857443-42889200 (-)



Homology
more
  • Human Ortholog
    CPN1, carboxypeptidase N subunit 1
  • Vertebrate Orthologs
    8
  • Human Ortholog
    CPN1, carboxypeptidase N subunit 1
    Orthology source: HomoloGene, HGNC
  • Synonyms
    CPN, SCPN
  • Links
    NCBI Gene ID: 1369
    neXtProt AC: NX_P15169
    UniProt: P15169

  • Chr Location
    10q24.2; chr10:100042308-100081885 (-)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    2 phenotypes from 1 allele in 1 genetic background
    1 phenotype from multigenic genotypes
    5 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele are highly susceptible to lethal anaphylactic shock caused by acute complement activation when administered cobra venom factor or C5a complement.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 93721 NCBI Gene Model | MGI Sequence Detail 30245 C57BL/6J ±  kb
transcript NM_030703 RefSeq | MGI Sequence Detail 1792 Not Specified  
polypeptide Q9JJN5 UniProt | EBI | MGI Sequence Detail 457 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 56
    Genomic 1
    cDNA 53
    Primer pair 2

    Microarray probesets 5
Other
Accession IDs
less
MGI:1923506
References
more
  • Summaries
    All 42
    Developmental Gene Expression 10
    Gene Ontology 6
    Phenotypes 5
  • Earliest
    J:68326 Sato T, et al., Pro-carboxypeptidase R is an acute phase protein in the mouse, whereas carboxypeptidase N is not. J Immunol. 2000 Jul 15;165(2):1053-8
  • Latest
    J:253278 Greig LC, et al., Ctip1 Controls Acquisition of Sensory Area Identity and Establishment of Sensory Input Fields in the Developing Neocortex. Neuron. 2016 Apr 20;90(2):261-77

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/06/2018
MGI 6.13
The Jackson Laboratory