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Hspb8 Gene Detail
Summary
  • Symbol
    Hspb8
  • Name
    heat shock protein 8
  • Synonyms
    Cryac, D5Ucla4, E2IG1, H11, H11K, HSP20-like, HSP22
  • Feature Type
    protein coding gene
  • IDs
    MGI:2135756
    NCBI Gene: 80888
  • Gene Overview
    MyGene.info: HSPB8
  • Alliance
  • Transcription Start Sites
    7 TSS
Location &
Maps
more
  • Sequence Map
    Chr5:116408491-116422864 bp, - strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 5, 56.41 cM
  • Mapping Data
    8 experiments
Strain
Comparison
more
  • SNPs within 2kb
    131 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2135756
protein coding gene Chr5:116408491-116422864 (-)
129S1/SvImJ MGP_129S1SvImJ_G0029981
protein coding gene Chr5:119401175-119420217 (-)
A/J MGP_AJ_G0029945
protein coding gene Chr5:114592953-114607214 (-)
AKR/J MGP_AKRJ_G0029884
protein coding gene Chr5:118279864-118295944 (-)
BALB/cJ MGP_BALBcJ_G0029956
protein coding gene Chr5:116002833-116018783 (-)
C3H/HeJ MGP_C3HHeJ_G0029676
protein coding gene Chr5:118795815-118810396 (-)
C57BL/6NJ MGP_C57BL6NJ_G0030411
protein coding gene Chr5:123955760-123972022 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0027637
protein coding gene Chr5:109368499-109384031 (-)
CAST/EiJ MGP_CASTEiJ_G0029085
protein coding gene Chr5:117767790-117787069 (-)
CBA/J MGP_CBAJ_G0029644
protein coding gene Chr5:128727138-128751834 (-)
DBA/2J MGP_DBA2J_G0029794
protein coding gene Chr5:114687023-114704904 (-)
FVB/NJ MGP_FVBNJ_G0029750
protein coding gene Chr5:113523800-113538006 (-)
LP/J MGP_LPJ_G0029882
protein coding gene Chr5:119922514-119938408 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0029781
protein coding gene Chr5:133015757-133034362 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0030452
protein coding gene Chr5:117784972-117799048 (-)
PWK/PhJ MGP_PWKPhJ_G0028798
protein coding gene Chr5:113350488-113366517 (-)
SPRET/EiJ MGP_SPRETEiJ_G0028636
protein coding gene Chr5:115322001-115339270 (-)
WSB/EiJ MGP_WSBEiJ_G0029160
protein coding gene Chr5:118369606-118391333 (-)



Homology
more
  • Human Ortholog
    HSPB8, heat shock protein family B (small) member 8
  • Vertebrate Orthologs
    10
  • Human Ortholog
    HSPB8, heat shock protein family B (small) member 8
    Orthology source: HomoloGene, HGNC
  • Synonyms
    CMT2L, DHMN2, E2IG1, H11, HMN2, HMN2A, HSP22
  • Links
    NCBI Gene ID: 26353
    neXtProt AC: NX_Q9UJY1
    UniProt: Q9UJY1

  • Chr Location
    12q24.23; chr12:119178790-119194746 (+)  GRCh38.p7

Human Diseases
more
  • Diseases
    1 with human HSPB8 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    12 phenotypes from 1 allele in 1 genetic background
    9 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
When exposed to pressure overload, mice homozygous for a knock-out allele develop less hypertrophy and display ventricular dilation, impaired contractile function, increased myocyte length and accumulation of interstitial collagen, accelerated transitioninto heart failure, and increased mortality.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 80888 NCBI Gene Model | MGI Sequence Detail 14374 C57BL/6J ±  kb
    transcript NM_030704 RefSeq | MGI Sequence Detail 1825 C57BL/6  
    polypeptide Q9JK92 UniProt | EBI | MGI Sequence Detail 196 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 136
      cDNA 133
      Primer pair 1
      Other 2

      Microarray probesets 6
    Other
    Accession IDs
    less
    MGD-MRK-7380, MGI:2141037, MGI:2141190, MGI:93475
    References
    more
    • Summaries
      All 63
      Developmental Gene Expression 10
      Gene Ontology 3
      Phenotypes 9
    • Earliest
      J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
    • Latest
      J:248802 Yamamoto N, et al., Heat shock protein 22 (HSPB8) limits TGF-beta-stimulated migration of osteoblasts. Mol Cell Endocrinol. 2016 Nov 15;436:1-9

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    11/06/2018
    MGI 6.13
    The Jackson Laboratory