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Hspb8
Gene Detail
 Symbol
Name
ID
Hspb8
heat shock protein 8
MGI:2135756
Synonyms Cryac, D5Ucla4, E2IG1, H11, H11K, HSP20-like, HSP22
Feature Type protein coding gene
Genetic Map
Chromosome 5
56.41 cM
Detailed Genetic Map ± 1 cM


Mapping data(8)
Sequence Map
Chr5:116408491-116422864 bp, - strand
From VEGA annotation of GRCm38

  14374 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:8654  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: Sm_HSP_B1
Gene Tree: Hspb8

Human
homologs
Human Homolog HSPB8, heat shock 22kDa protein 8
NCBI Gene ID 26353
neXtProt AC  NX_Q9UJY1
Human Synonyms  CMT2L, DHMN2, E2IG1, H11, HMN2, HMN2A, HSP22
Human Chr (Location)  12q24.23; chr12:119178790-119194746 (+)  GRCh38
Disease Associations  (2) Diseases Associated with Human HSPB8
Mutations,
alleles, and
phenotypes
All mutations/alleles(16) : Gene trapped(15) Targeted(1)
Incidental mutations (data from Mutagenetix , APF )
 
When exposed to pressure overload, mice homozygous for a knock-out allele develop less hypertrophy and display ventricular dilation, impaired contractile function, increased myocyte length and accumulation of interstitial collagen, accelerated transition into heart failure, and increased mortality.
 
Interactions
Hspb8 interacts with 103 markers (Mir7-1, Mir10a, Mir10b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (6 annotations)
Process response to stress
Component cytoplasm, intracellular, ...
Function identical protein binding, protein binding
External Resources: FuncBase
Expression
Literature Summary: (9 records)
Data Summary: Results (176)    Tissues (131)    Images (36)
Theiler Stages: 15, 20, 21, 22, 23, 25, 27, 28
Assay TypeResults
Immunohistochemistry 4
RNA in situ 132
Northern blot 40
cDNA source data(132)
External Resources: Allen Institute   GENSAT   GEO   Expression Atlas
Molecular
reagents
All nucleic(133) cDNA(132) Other(1)
Microarray probesets(6)
Other database
links
VEGA Gene ModelOTTMUSG00000014696 (Evidence)
Ensembl Gene ModelENSMUSG00000041548 (Evidence)
Entrez Gene80888 (Evidence)
UniGene21549
DFCITC1574577, TC1759947
DoTSDT.535654, DT.97408252
NIA Mouse Gene IndexU026646
Consensus CDS ProjectCCDS19600.1
International Mouse Knockout Project StatusHspb8
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000014696 VEGA Gene Model | MGI Sequence Detail 14374 C57BL/6J ±  kb
transcript OTTMUST00000034849 VEGA | MGI Sequence Detail 1816 Not Applicable 
polypeptide OTTMUSP00000015583 VEGA | MGI Sequence Detail 196 Not Applicable 

For the selected sequences
All sequences(37) RefSeq(2) UniProt(1)
Polymorphisms RFLP(1) : SNPs within 2kb(133 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001436 Alpha crystallin/Heat shock protein
InterPro IPR002068 Alpha crystallin/Hsp20 domain
InterPro IPR008978 HSP20-like chaperone
Protein Ontology PR:000008820 heat shock protein beta-8
References (Earliest) J:15567 Warden CH, et al., Linkage mapping of 40 randomly isolated liver cDNA clones in the mouse. Genomics. 1993 Nov;18(2):295-307
(Latest) J:196584 Ramirez-Rodriguez G, et al., The alpha crystallin domain of small heat shock protein b8 (Hspb8) acts as survival and differentiation factor in adult hippocampal neurogenesis. J Neurosci. 2013 Mar 27;33(13):5785-96
All references(56)
Other
accession IDs
MGD-MRK-7380, MGI:2141037, MGI:2141190, MGI:93475

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/09/2014
MGI 5.19
The Jackson Laboratory