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Cox4i2
Gene Detail
 Symbol
Name
ID
Cox4i2
cytochrome c oxidase subunit IV isoform 2
MGI:2135755
Synonyms Cox4b, Cox IV-2
Feature Type protein coding gene
Genetic Map
Chromosome 2
75.41 cM, cytoband H2
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr2:152754173-152765037 bp, + strand
From VEGA annotation of GRCm38

  10865 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:13082  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 western clawed frog

Protein SuperFamily: cytochrome-c oxidase chain IV
Gene Tree: Cox4i2

Human
homologs
Human Homolog COX4I2, cytochrome c oxidase subunit IV isoform 2 (lung)
NCBI Gene ID 84701
neXtProt AC  NX_Q96KJ9
Human Synonyms  COX4, COX4-2, COX4B, COX4L2, COXIV-2, dJ857M17.2
Human Chr (Location)  20q11.21; chr20:31637882-31645032 (+)  GRCh38
Disease Associations  (1) Diseases Associated with Human COX4I2
Mutations,
alleles, and
phenotypes
All mutations/alleles(15) : Gene trapped(10) Targeted(5)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a null mutation display lung inflammation and decreased airway responsiveness. Females show decreased lean body mass and improved glucose tolerance.
 
Interactions
Cox4i2 interacts with 16 markers (Mir139, Mir320, Mir325, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (10 annotations)
Process hydrogen ion transmembrane transport, oxidation-reduction process
Component membrane, mitochondrial inner membrane, ...
Function cytochrome-c oxidase activity
External Resources: FuncBase
Expression
Literature Summary: (2 records)
Data Summary: Results (97)    Tissues (97)    Images (15)
Theiler Stages: 22, 28
Assay TypeResults
RNA in situ 94
RT-PCR 3
cDNA source data(9)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(11) cDNA(9) Primer pair(2)
Microarray probesets(2)
Other database
links
VEGA Gene ModelOTTMUSG00000015832 (Evidence)
Ensembl Gene ModelENSMUSG00000009876 (Evidence)
Entrez Gene84682 (Evidence)
UniGene196668
DFCITC1588791
DoTSDT.101252492, DT.525817
NIA Mouse Gene IndexU002654
Consensus CDS ProjectCCDS16898.1
International Mouse Knockout Project StatusCox4i2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000015832 VEGA Gene Model | MGI Sequence Detail 10865 C57BL/6J ±  kb
transcript OTTMUST00000037638 VEGA | MGI Sequence Detail 727 Not Applicable 
polypeptide OTTMUSP00000016874 VEGA | MGI Sequence Detail 172 Not Applicable 

For the selected sequences
All sequences(20) RefSeq(2) UniProt(1)
Polymorphisms SNPs within 2kb(148 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR013288 Cytochrome c oxidase subunit IV
InterPro IPR004203 Cytochrome c oxidase subunit IV family
Protein Ontology PR:000005777 cytochrome c oxidase subunit 4 isoform 2, mitochondrial
References (Earliest) J:68890 Huttemann M, et al., Mammalian subunit IV isoforms of cytochrome c oxidase. Gene. 2001 Apr 4;267(1):111-23
(Latest) J:187640 Huttemann M, et al., Cytochrome c oxidase subunit 4 isoform 2-knockout mice show reduced enzyme activity, airway hyporeactivity, and lung pathology. FASEB J. 2012 Sep;26(9):3916-30
All references(30)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/23/2014
MGI 5.19
The Jackson Laboratory