Cox4i2
Gene Detail

Symbol Name ID

Cox4i2 cytochrome c oxidase subunit IV isoform 2 MGI:2135755

Synonyms

Cox4b, Cox IV-2

Feature Type

protein coding gene

Genetic Map

Chromosome 2

75.41 cM, cytoband H2
Detailed Genetic Map ± 1 cM


Mapping data(1)

Sequence Map

Chr2:152754173-152765037 bp, + strand From VEGA annotation of GRCm38   10865 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:13082  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 zebrafish

Protein SuperFamily: cytochrome-c oxidase chain IV
Gene Tree: Cox4i2

Human homologs

Human Homolog		COX4I2, cytochrome c oxidase subunit IV isoform 2 (lung)
NCBI Gene ID		84701
neXtProt AC		NX_Q96KJ9
Human Synonyms		COX4, COX4-2, COX4B, COX4L2, COXIV-2, dJ857M17.2
Human Chr (Location)		20q11.21; chr20:30225691-30232800 (+)  GRCh37.p10
Disease Associations		(1) Diseases Associated with Human COX4I2

Alleles and phenotypes

All alleles(15) : Targeted(5) Gene trapped(10)
 

Mice homozygous for a null mutation display lung inflammation and decreased airway responsiveness. Females show decreased lean body mass and improved glucose tolerance.

 

Gene Ontology (GO) classifications

All GO classifications: (10 annotations)

Process	ion transmembrane transport, oxidation-reduction process, ...
Component	membrane, mitochondrial inner membrane, ...
Function	cytochrome-c oxidase activity

External Resources: FuncBase

Expression

Literature Summary: (2 records)
Data Summary: Results (97)    Tissues (97)    Images (15)
Theiler Stages: 22, 28

Assay Type	Results
RNA in situ	94
RT-PCR	3

cDNA source data(9)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(11) cDNA(9) Primer pair(2)
Microarray probesets(2)

Other database links

VEGA Gene Model	OTTMUSG00000015832 (Evidence)
Ensembl Gene Model	ENSMUSG00000009876 (Evidence)
Entrez Gene	84682 (Evidence)
UniGene	196668
DFCI	TC1588791
DoTS	DT.101252492, DT.525817
NIA Mouse Gene Index	U002654
Consensus CDS Project	CCDS16898.1
International Mouse Knockout Project Status	Cox4i2

Sequences

Length	Strain/Species
genomic	OTTMUSG00000015832	VEGA Gene Model | MGI Sequence Detail	10865	C57BL/6J
transcript	OTTMUST00000037638	VEGA | MGI Sequence Detail	727	Not Applicable
polypeptide	OTTMUSP00000016874	VEGA | MGI Sequence Detail	172	Not Applicable

All sequences(21) RefSeq(2) UniProt(2)

Polymorphisms

SNPs(55 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR013288	Cytochrome c oxidase subunit IV
InterPro	IPR004203	Cytochrome c oxidase subunit IV family
Protein Ontology	PR:000005777	cytochrome c oxidase subunit 4 isoform 2, mitochondrial
Protein Ontology	PR:000025369	cytochrome c oxidase subunit 4 isoform 2, mitochondrial (mouse)

References

(Earliest) J:68890 Huttemann M, et al., Mammalian subunit IV isoforms of cytochrome c oxidase. Gene. 2001 Apr 4;267(1):111-23
(Latest) J:187640 Huttemann M, et al., Cytochrome c oxidase subunit 4 isoform 2-knockout mice show reduced enzyme activity, airway hyporeactivity, and lung pathology. FASEB J. 2012 Sep;26(9):3916-30
All references(30)