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Glrx Gene Detail
Summary
  • Symbol
    Glrx
  • Name
    glutaredoxin
  • Synonyms
    D13Wsu156e, Grx1, TTase
  • Feature Type
    protein coding gene
  • IDs
    MGI:2135625
    NCBI Gene: 93692
  • Gene Overview
    MyGene.info: GLRX
  • Alliance
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr13:75839873-75850151 bp, + strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 13, 40.95 cM
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    96 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2135625
protein coding gene Chr13:75839868-75850154 (.)
129S1/SvImJ MGP_129S1SvImJ_G0020772
protein coding gene Chr13:76376783-76387410 (+)
A/J MGP_AJ_G0020728
protein coding gene Chr13:73771607-73782020 (+)
AKR/J MGP_AKRJ_G0020701
protein coding gene Chr13:76017974-76030429 (+)
BALB/cJ MGP_BALBcJ_G0020724
protein coding gene Chr13:74252926-74263135 (+)
C3H/HeJ MGP_C3HHeJ_G0020518
protein coding gene Chr13:75716666-75727081 (+)
C57BL/6NJ MGP_C57BL6NJ_G0021161
protein coding gene Chr13:78953672-78965235 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0018729
protein coding gene Chr13:70600235-70611191 (+)
CAST/EiJ MGP_CASTEiJ_G0020036
protein coding gene Chr13:74821469-74831097 (+)
CBA/J MGP_CBAJ_G0020477
protein coding gene Chr13:81949067-81960322 (+)
DBA/2J MGP_DBA2J_G0020602
protein coding gene Chr13:73495576-73505772 (+)
FVB/NJ MGP_FVBNJ_G0020582
protein coding gene Chr13:72549370-72559577 (+)
LP/J MGP_LPJ_G0020675
protein coding gene Chr13:76658912-76670560 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0020611
protein coding gene Chr13:80341543-80352490 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0021201
protein coding gene Chr13:75337998-75349280 (+)
PWK/PhJ MGP_PWKPhJ_G0019789
protein coding gene Chr13:72387799-72397520 (+)
SPRET/EiJ MGP_SPRETEiJ_G0019612
protein coding gene Chr13:71720978-71734539 (+)
WSB/EiJ MGP_WSBEiJ_G0020093
protein coding gene Chr13:75843087-75853712 (+)



Homology
more
  • Human Ortholog
    GLRX, glutaredoxin
  • Vertebrate Orthologs
    13
  • Human Ortholog
    GLRX, glutaredoxin
    Orthology source: HomoloGene, HGNC
  • Synonyms
    GRX, GRX1
  • Links
    NCBI Gene ID: 2745
    neXtProt AC: NX_P35754
    UniProt: P35754

  • Chr Location
    5q15; chr5:95813849-95822873 (-)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 37566
    1 human;1 mouse;1 rat;1 chimpanzee;4 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: GLRX
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    9 phenotypes from 2 alleles in 1 genetic background
    1 phenotype from multigenic genotypes
    23 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele do not exhibit any increased injury in response to oxidative insults to the heart or lungs but mouse embryonic fibroblast derived from these embryos are more sensative to diquat and paraqut and more resistant to apoptosis induced by TNF-alpha plus actinomyosin D.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 93692 NCBI Gene Model | MGI Sequence Detail 10279 C57BL/6J ±  kb
    transcript NM_053108 RefSeq | MGI Sequence Detail 1335 C57BL/6  
    polypeptide Q9QUH0 UniProt | EBI | MGI Sequence Detail 107 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 119
      cDNA 118
      Primer pair 1

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGD-MRK-36165, MGI:107593, MGI:2145532
    References
    more
    • Summaries
      All 63
      Developmental Gene Expression 4
      Gene Ontology 7
      Phenotypes 23
    • Earliest
      J:182573 Roderick TH, Producing and detecting paracentric chromosomal inversions in mice. Mutat Res. 1971 Jan;11(1):59-69
    • Latest
      J:254286 Zhang X, et al., Positive Regulation of Interleukin-1beta Bioactivity by Physiological ROS-Mediated Cysteine S-Glutathionylation. Cell Rep. 2017 Jul 5;20(1):224-235

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
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    last database update
    11/06/2018
    MGI 6.13
    The Jackson Laboratory