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Glrx
Gene Detail
Symbol

Name
ID
Glrx
glutaredoxin
MGI:2135625
Synonyms
D13Wsu156e, Grx1, TTase
Feature Type
protein coding gene
Genetic Map
Chromosome 13
40.95 cM
Detailed Genetic Map ± 1 cM


Mapping data(4)
Sequence Map
Chr13:75839868-75850151 bp, + strand
From VEGA annotation of GRCm38

  10284 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:37566  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 4 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: GLRX
Gene Tree: Glrx

Human
homologs
GLRX, glutaredoxin (thioltransferase)
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 2745
neXtProt AC: NX_P35754

Human Synonyms: GRX, GRX1

Human Chr (Location): 5q14; chr5:95813849-95822873 (-)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(4) : Targeted(4)
 
Mice homozygous for a null allele do not exhibit any increased injury in response to oxidative insults to the heart or lungs but mouse embryonic fibroblast derived from these embryos are more sensative to diquat and paraqut and more resistant to apoptosis induced by TNF-alpha plus actinomyosin D.
 
Interactions
Glrx interacts with 148 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (27 annotations)
Process cell redox homeostasis, cellular response to estradiol stimulus, ...
Component cytoplasm, cytosol, ...
Function electron carrier activity, glutathione disulfide oxidoreductase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (4 records)
Data Summary: Results (100)    Tissues (96)    Images (2)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 94
RT-PCR 6
cDNA source data(116)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase glrx ; ZFIN glrx    NEW 
Molecular
reagents
All nucleic(118) cDNA(117) Primer pair(1)
Microarray probesets(4)
Other database
links
VEGA Gene Model OTTMUSG00000020964 (Evidence)
Ensembl Gene Model ENSMUSG00000021591 (Evidence)
Entrez Gene 93692 (Evidence)
UniGene 25844
DFCI TC1574293
DoTS DT.535890, DT.94359185, DT.110960791
NIA Mouse Gene Index U015030
Consensus CDS Project CCDS26651.1
International Mouse Phenotyping Consortium Status Glrx
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000020964 VEGA Gene Model | MGI Sequence Detail 10284 C57BL/6J ±  kb
transcript OTTMUST00000049564 VEGA | MGI Sequence Detail 1345 Not Applicable 
polypeptide OTTMUSP00000022985 VEGA | MGI Sequence Detail 107 Not Applicable 

For the selected sequences
All sequences(30) RefSeq(4) UniProt(2)
Polymorphisms
SNPs within 2kb(99 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR002109 Glutaredoxin
InterPro IPR011767 Glutaredoxin active site
InterPro IPR011899 Glutaredoxin, eukaryotic/virial
InterPro IPR014025 Glutaredoxin subgroup
InterPro IPR012336 Thioredoxin-like fold
Protein Ontology PR:000008047 glutaredoxin-1
References
(Earliest) J:50869 Ko MSH, et al., Genome-wide mapping of unselected transcripts from extraembryonic tissue of 7.5-day mouse embryos reveals enrichment in the t-complex and under-representation on the X chromosome. Hum Mol Genet. 1998 Nov;7(12):1967-78
(Latest) J:210053 De Benedetto ML, et al., Glutaredoxin 1 is a major player in copper metabolism in neuroblastoma cells. Biochim Biophys Acta. 2014 Jan;1840(1):255-61
All references(51)
Other
accession IDs
MGD-MRK-36165, MGI:107593, MGI:2145532

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/21/2015
MGI 5.22
The Jackson Laboratory