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Immp2l Gene Detail
Summary
  • Symbol
    Immp2l
  • Name
    IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae)
  • Synonyms
    IMP2
  • Feature Type
    protein coding gene
  • IDs
    MGI:2135611
    NCBI Gene: 93757
Location & Maps
more
  • Sequence Map
    Chr12:41024090-41955588 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      931499 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 12, 18.69 cM, cytoband B3
  • Mapping Data
    3 experiments
Homology
more
  • Human Ortholog
    IMMP2L, inner mitochondrial membrane peptidase subunit 2
  • Vertebrate Orthologs
    10
  • Human Ortholog
    IMMP2L, inner mitochondrial membrane peptidase subunit 2
    Orthology source: HomoloGene, HGNC
  • Synonyms
    IMMP2L-IT1, IMP2, IMP2-LIKE
  • Links
    NCBI Gene ID: 83943
    neXtProt AC: NX_Q96T52

  • Chr Location
    7q31.1; chr7:110662645-111562531 (-)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    14 phenotypes from multigenic genotypes
    14 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    64
  • Chemically induced (ENU)
    1
  • Gene trapped
    61
  • Targeted
    1
  • Transgenic
    1
  • Incidental Mutations
    APF
Mice homozygous for a transgenic gene disruption exhibit reduced fertility, abnormal cellular respiration, and decreased body weight.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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  • cDNA Data
Interactions
less
Sequences &
Gene Models
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  • All Sequences
  • RefSeq
  • UniProt
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000033105 VEGA Gene Model | MGI Sequence Detail 931499 C57BL/6J ±  kb
transcript OTTMUST00000082746 VEGA | MGI Sequence Detail 977 Not Applicable  
polypeptide OTTMUSP00000044389 VEGA | MGI Sequence Detail 175 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    6324 from dbSNP Build 142
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 5
    cDNA 5

    Microarray probesets 4
Other
Accession IDs
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MGI:2144909
References
more
  • Summaries
    All 38
    Gene Ontology 8
    Phenotypes 14
  • Earliest
    J:68676 Petek E, et al., Disruption of a novel gene (IMMP2L) by a breakpoint in 7q31 associated with Tourette syndrome. Am J Hum Genet. 2001 Apr;68(4):848-58
  • Latest
    J:231343 Liu C, et al., The Immp2l mutation causes age-dependent degeneration of cerebellar granule neurons prevented by antioxidant treatment. Aging Cell. 2016 Feb;15(1):167-76

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/22/2016
MGI 6.06
The Jackson Laboratory