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Lin7a Gene Detail
Summary
  • Symbol
    Lin7a
  • Name
    lin-7 homolog A (C. elegans)
  • Synonyms
    LIN-7A, MALS-1, TIP-33, Veli
  • Feature Type
    protein coding gene
  • IDs
    MGI:2135609
    NCBI Gene: 108030
  • Gene Overview
    MyGene.info: LIN7A
  • Alliance
  • Transcription Start Sites
    7 TSS
Location &
Maps
more
  • Sequence Map
    Chr10:107271686-107421474 bp, + strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 10, 55.83 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    653 from dbSNP Build 142
  • Strain Annotations
    17
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2135609
protein coding gene Chr10:107271599-107425146 (.)
129S1/SvImJ MGP_129S1SvImJ_G0017707
protein coding gene Chr10:109450394-109606717 (+)
A/J MGP_AJ_G0017684
protein coding gene Chr10:105362060-105511051 (+)
AKR/J MGP_AKRJ_G0017646
protein coding gene Chr10:108429728-108575971 (+)
BALB/cJ MGP_BALBcJ_G0017648
protein coding gene Chr10:105749362-105900493 (+)
C3H/HeJ MGP_C3HHeJ_G0017473
protein coding gene Chr10:108517822-108672619 (+)
C57BL/6NJ MGP_C57BL6NJ_G0018105
protein coding gene Chr10:113257353-113416687 (+)
CAROLI/EiJ no annotation
CAST/EiJ MGP_CASTEiJ_G0017034
protein coding gene Chr10:108614966-108766876 (+)
CBA/J MGP_CBAJ_G0017442
protein coding gene Chr10:117661072-117826666 (+)
DBA/2J MGP_DBA2J_G0017547
protein coding gene Chr10:104498403-104649692 (+)
FVB/NJ MGP_FVBNJ_G0017541
protein coding gene Chr10:103499844-103648620 (+)
LP/J MGP_LPJ_G0017621
protein coding gene Chr10:110080097-110235443 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0017571
protein coding gene Chr10:120175926-120343897 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0018143
protein coding gene Chr10:108404580-108564909 (+)
PWK/PhJ MGP_PWKPhJ_G0016816
protein coding gene Chr10:104553555-104700950 (+)
SPRET/EiJ MGP_SPRETEiJ_G0016606
protein coding gene Chr10:107161481-107304617 (+)
WSB/EiJ MGP_WSBEiJ_G0017094
protein coding gene Chr10:108525108-108683178 (+)



Homology
more
  • Human Ortholog
    LIN7A, lin-7 homolog A, crumbs cell polarity complex component
  • Vertebrate Orthologs
    9
  • Human Ortholog
    LIN7A, lin-7 homolog A, crumbs cell polarity complex component
    Orthology source: HomoloGene, HGNC
  • Synonyms
    LIN7, LIN-7A, MALS1, MALS-1, TIP-33, VELI1
  • Links
    NCBI Gene ID: 8825
    neXtProt AC: NX_O14910
    UniProt: O14910

  • Chr Location
    12q21.31; chr12:80792520-80937915 (-)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    6 phenotypes from multigenic genotypes
    9 phenotype references
Mice homozygous for disruptions in this gene display a normal phenotype.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000019906 Ensembl Gene Model | MGI Sequence Detail 149789 C57BL/6J ±  kb
transcript ENSMUST00000020057 Ensembl | MGI Sequence Detail 2363 Not Applicable  
polypeptide ENSMUSP00000020057 Ensembl | MGI Sequence Detail 233 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 30
    cDNA 30

    Microarray probesets 7
Other
Accession IDs
less
MGI:2143687
References
more
  • Summaries
    All 49
    Developmental Gene Expression 7
    Gene Ontology 11
    Phenotypes 9
  • Earliest
    J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
  • Latest
    J:234018 Singh S, et al., Zeb1 controls neuron differentiation and germinal zone exit by a mesenchymal-epithelial-like transition. Elife. 2016;5

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/06/2018
MGI 6.13
The Jackson Laboratory