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Pard3
Gene Detail
 Symbol
Name
ID
Pard3
par-3 family cell polarity regulator
MGI:2135608
Synonyms ASIP, D8Ertd580e, Par3, PAR-3, Pard3a
Feature Type protein coding gene
Genetic Map
Chromosome 8
74.66 cM, cytoband E2
Detailed Genetic Map ± 1 cM


Mapping data(4)
Sequence Map
Chr8:127063893-127612286 bp, + strand
From VEGA annotation of GRCm38

  548394 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:10489  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: polarity protein Par-3
Gene Tree: Pard3

Human
homologs
Human Homolog PARD3, par-3 family cell polarity regulator
NCBI Gene ID 56288
neXtProt AC  NX_Q8TEW0
Human Synonyms  ASIP, Baz, PAR3, PAR3alpha, PARD-3, PARD3A, PPP1R118, SE2-5L16, SE2-5LT1, SE2-5T2
Human Chr (Location)  10p11.21; chr10:34109560-34815325 (-)  GRCh38
Alleles
and
phenotypes
All alleles(54) : Gene trapped(50) Targeted(4)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a null allele exhibit embryonic lethality at E12.5 associated with growth retardation, abnormal heart development, and abnormal epicardial cell development.
 
Gene Ontology
(GO)
classifications
All GO classifications: (50 annotations)
Process apical constriction, cell cycle, ...
Component adherens junction, apical part of cell, ...
Function lipid binding, phosphatidylinositol-3,4,5-trisphosphate binding, ...
External Resources: FuncBase
Expression
Literature Summary: (61 records)
Data Summary: Results (46)    Tissues (35)    Images (25)
Theiler Stages: 10, 15, 17, 18, 19, 20, 21, 22, 23, 24, 25, 28
Assay TypeResults
Immunohistochemistry 10
RNA in situ 15
Northern blot 4
Western blot 17
cDNA source data(130)
External Resources: Allen Institute   GEO   ArrayExpress
Molecular
reagents
All nucleic(132) cDNA(131) Primer pair(1)
Microarray probesets(9)
Other database
links
VEGA Gene ModelOTTMUSG00000034639 (Evidence)
Ensembl Gene ModelENSMUSG00000025812 (Evidence)
Entrez Gene93742 (Evidence)
UniGene299254
DFCITC1577001, TC1583670, TC1586628, TC1601509, TC1602924, TC1612114, TC1735384, TC1768501
DoTSDT.101125037, DT.101198259, DT.101329127, DT.101391596, DT.101738259, DT.486988, DT.55261873, DT.87025913, DT.91334144, DT.91432128
NIA Mouse Gene IndexU009992
PDB2KOH, 2KOJ
Consensus CDS ProjectCCDS22788.1, CCDS22789.1, CCDS40523.1, CCDS52712.1
International Mouse Knockout Project StatusPard3
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000034639 VEGA Gene Model | MGI Sequence Detail 548394 C57BL/6J ±  kb
transcript OTTMUST00000087923 VEGA | MGI Sequence Detail 5815 Not Applicable 
polypeptide OTTMUSP00000047887 VEGA | MGI Sequence Detail 1334 Not Applicable 

For the selected sequences
All sequences(215) RefSeq(36) UniProt(23)
Polymorphisms SNPs within 2kb(3601 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001478 PDZ domain
InterPro IPR021922 Protein of unknown function DUF3534
Protein Ontology PR:000012279 partitioning defective 3
References (Earliest) J:93290 Araki K, et al., Exchangeable gene trap using the Cre/mutated lox system. Cell Mol Biol (Noisy-le-grand). 1999 Jul;45(5):737-50
(Latest) J:206576 Fukuda T, et al., Aberrant cochlear hair cell attachments caused by Nectin-3 deficiency result in hair bundle abnormalities. Development. 2014 Jan;141(2):399-409
All references(120)
Other
accession IDs
MGI:1261826, MGI:2142456, MGI:2142486

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/15/2014
MGI 5.18
The Jackson Laboratory