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Pard3
Gene Detail
Symbol

Name
ID
Pard3
par-3 family cell polarity regulator
MGI:2135608
Synonyms
ASIP, D8Ertd580e, Par3, PAR-3, Pard3a
Feature Type
protein coding gene
Genetic Map
Chromosome 8
74.66 cM, cytoband E2
Detailed Genetic Map ± 1 cM


Mapping data(4)
Sequence Map
Chr8:127063893-127612286 bp, + strand
From VEGA annotation of GRCm38

  548394 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:10489  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: polarity protein Par-3
Gene Tree: Pard3

Human
homologs
Human Homolog PARD3, par-3 family cell polarity regulator
NCBI Gene ID 56288
neXtProt AC  NX_Q8TEW0
Human Synonyms  ASIP, Baz, PAR3, PAR3alpha, PARD-3, PARD3A, PPP1R118, SE2-5L16, SE2-5LT1, SE2-5T2
Human Chr (Location)  10p11.21; chr10:34109560-34815325 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(54) : Gene trapped(50) Targeted(4)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a null allele exhibit embryonic lethality at E12.5 associated with growth retardation, abnormal heart development, and abnormal epicardial cell development.
 
Interactions
Pard3 interacts with 305 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (52 annotations)
Process apical constriction, cell cycle, ...
Component adherens junction, apical part of cell, ...
Function lipid binding, phosphatidylinositol-3,4,5-trisphosphate binding, ...
External Resources: FuncBase
Expression
Literature Summary: (64 records)
Data Summary: Results (46)    Tissues (35)    Images (25)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 10
RNA in situ 15
Northern blot 4
Western blot 17
cDNA source data(130)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(132) cDNA(131) Primer pair(1)
Microarray probesets(9)
Other database
links
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000034639 VEGA Gene Model | MGI Sequence Detail 548394 C57BL/6J ±  kb
transcript OTTMUST00000087923 VEGA | MGI Sequence Detail 5815 Not Applicable 
polypeptide OTTMUSP00000047887 VEGA | MGI Sequence Detail 1334 Not Applicable 

For the selected sequences
All sequences(237) RefSeq(36) UniProt(45)
Polymorphisms
SNPs within 2kb(3601 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001478 PDZ domain
InterPro IPR021922 Protein of unknown function DUF3534
Protein Ontology PR:000012279 partitioning defective 3
References
(Earliest) J:93290 Araki K, et al., Exchangeable gene trap using the Cre/mutated lox system. Cell Mol Biol (Noisy-le-grand). 1999 Jul;45(5):737-50
(Latest) J:211342 Kielar M, et al., Mutations in Eml1 lead to ectopic progenitors and neuronal heterotopia in mouse and human. Nat Neurosci. 2014 Jul;17(7):923-33
All references(123)
Other
accession IDs
MGI:1261826, MGI:2142456, MGI:2142486

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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Funding Information
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last database update
11/18/2014
MGI 5.20
The Jackson Laboratory