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Pard3
Gene Detail
Symbol

Name
ID
Pard3
par-3 family cell polarity regulator
MGI:2135608
Synonyms
ASIP, D8Ertd580e, Par3, PAR-3, Pard3a
Feature Type
protein coding gene
Genetic Map
Chromosome 8
74.66 cM, cytoband E2
Detailed Genetic Map ± 1 cM


Mapping data(4)
Sequence Map
Chr8:127063893-127612286 bp, + strand
From VEGA annotation of GRCm38

  548394 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:10489  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: PARD3
Protein SuperFamily: polarity protein Par-3
Gene Tree: Pard3

Human
homologs
PARD3, par-3 family cell polarity regulator
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 56288
neXtProt AC: NX_Q8TEW0

Human Synonyms: ASIP, Baz, PAR3, PAR3alpha, PARD-3, PARD3A, PPP1R118, SE2-5L16, SE2-5LT1, SE2-5T2

Human Chr (Location): 10p11.21; chr10:34109560-34815325 (-)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(55) : Gene trapped(50) Targeted(5)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Mice homozygous for a null allele exhibit embryonic lethality at E12.5 associated with growth retardation, abnormal heart development, and abnormal epicardial cell development.
 
Interactions
Pard3 interacts with 304 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (52 annotations)
Process apical constriction, bicellular tight junction assembly, ...
Component adherens junction, apical part of cell, ...
Function lipid binding, phosphatidylinositol-3,4,5-trisphosphate binding, ...
External Resources: FuncBase
Expression
Literature Summary: (68 records)
Data Summary: Results (46)    Tissues (35)    Images (25)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 10
RNA in situ 15
Northern blot 4
Western blot 17
cDNA source data(130)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase pard3    NEW 
Molecular
reagents
All nucleic(132) cDNA(131) Primer pair(1)
Microarray probesets(9)
Other database
links
VEGA Gene Model OTTMUSG00000034639 (Evidence)
Ensembl Gene Model ENSMUSG00000025812 (Evidence)
Entrez Gene 93742 (Evidence)
UniGene 299254
DFCI TC1577001, TC1601509, TC1583670, TC1586628, TC1602924, TC1768501, TC1735384, TC1612114
DoTS DT.101391596, DT.101329127, DT.101198259, DT.101125037, DT.101738259, DT.55261873, DT.486988, DT.91432128, DT.91334144, DT.87025913
NIA Mouse Gene Index U009992
PDB 2KOJ, 2KOH
Consensus CDS Project CCDS22788.1, CCDS22789.1, CCDS40523.1, CCDS52712.1
International Mouse Phenotyping Consortium Status Pard3
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000034639 VEGA Gene Model | MGI Sequence Detail 548394 C57BL/6J ±  kb
transcript OTTMUST00000087923 VEGA | MGI Sequence Detail 5815 Not Applicable 
polypeptide OTTMUSP00000047887 VEGA | MGI Sequence Detail 1334 Not Applicable 

For the selected sequences
All sequences(219) RefSeq(38) UniProt(23)
Polymorphisms
SNPs within 2kb(3601 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001478 PDZ domain
InterPro IPR021922 Protein of unknown function DUF3534
Protein Ontology PR:000012279 partitioning defective 3
References
(Earliest) J:93290 Araki K, et al., Exchangeable gene trap using the Cre/mutated lox system. Cell Mol Biol (Noisy-le-grand). 1999 Jul;45(5):737-50
(Latest) J:220469 Grego-Bessa J, et al., Morphogenesis of the mouse neural plate depends on distinct roles of cofilin 1 in apical and basal epithelial domains. Development. 2015 Apr 1;142(7):1305-14
All references(127)
Other
accession IDs
MGI:1261826, MGI:2142456, MGI:2142486

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
06/23/2015
MGI 5.22
The Jackson Laboratory