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Clec2d Gene Detail
Summary
  • Symbol
    Clec2d
  • Name
    C-type lectin domain family 2, member d
  • Synonyms
    Clrb, Clr-b, Ocil
  • Feature Type
    protein coding gene
  • IDs
    MGI:2135589
    NCBI Gene: 93694
  • Alliance
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr6:129180615-129186534 bp, + strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 6, 63.16 cM, cytoband F3
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    44 from dbSNP Build 142
  • Strain Annotations
    16
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2135589
protein coding gene Chr6:129180615-129186535 (+)
129S1/SvImJ MGP_129S1SvImJ_G0031341
protein coding gene Chr6:132835555-132844328 (+)
A/J MGP_AJ_G0031312
protein coding gene Chr6:127750178-127756349 (+)
AKR/J MGP_AKRJ_G0031240
protein coding gene Chr6:131234139-131239976 (+)
BALB/cJ MGP_BALBcJ_G0031319
protein coding gene Chr6:127389280-127401617 (+)
C3H/HeJ MGP_C3HHeJ_G0031043
protein coding gene Chr6:131429053-131435593 (+)
C57BL/6NJ MGP_C57BL6NJ_G0031778
protein coding gene Chr6:136313469-136319389 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0028924
protein coding gene Chr6:125265539-125271702 (+)
CAST/EiJ no annotation
CBA/J no annotation
DBA/2J MGP_DBA2J_G0031158
protein coding gene Chr6:126497482-126505525 (+)
FVB/NJ MGP_FVBNJ_G0031110
protein coding gene Chr6:125582371-125591801 (+)
LP/J MGP_LPJ_G0031240
protein coding gene Chr6:133042782-133055839 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0031146
protein coding gene Chr6:145276040-145284127 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0031811
protein coding gene Chr6:131298622-131304264 (+)
PWK/PhJ MGP_PWKPhJ_G0030138
protein coding gene Chr6:124986168-124993297 (+)
SPRET/EiJ MGP_SPRETEiJ_G0029968
protein coding gene Chr6:129324863-129331862 (+)
WSB/EiJ MGP_WSBEiJ_G0030506
protein coding gene Chr6:131366798-131501428 (+)



Homology
less
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    14 phenotypes from 1 allele in 2 genetic backgrounds
    6 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Enhanced osteoclastic activity in the bone of homozygous null mice leads to osteopenia and high serum calcium levels.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000030157 Ensembl Gene Model | MGI Sequence Detail 5920 C57BL/6J ±  kb
    transcript ENSMUST00000032260 Ensembl | MGI Sequence Detail 1213 Not Applicable  
    polypeptide ENSMUSP00000032260 Ensembl | MGI Sequence Detail 207 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      2 Sequences
    • PDB
    • InterPro Domains
      IPR016187 C-type lectin fold
      IPR001304 C-type lectin-like
      IPR016186 C-type lectin-like/link domain superfamily
      IPR033992 Natural killer cell receptor-like, C-type lectin-like domain
    Molecular
    Reagents
    less
    • All nucleic 17
      cDNA 16
      Primer pair 1

      Microarray probesets 2
    References
    more
    • Summaries
      All 31
      Developmental Gene Expression 4
      Gene Ontology 6
      Phenotypes 6
    • Earliest
      J:69269 Zhou H, et al., A novel osteoblast-derived C-type lectin that inhibits osteoclast formation. J Biol Chem. 2001 May 4;276(18):14916-23
    • Latest
      J:263942 Tanaka M, et al., The Inhibitory NKR-P1B:Clr-b Recognition Axis Facilitates Detection of Oncogenic Transformation and Cancer Immunosurveillance. Cancer Res. 2018 Jul 1;78(13):3589-3603

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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    last database update
    06/04/2019
    MGI 6.14
    The Jackson Laboratory