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Klf7
Gene Detail
Symbol

Name
ID
Klf7
Kruppel-like factor 7 (ubiquitous)
MGI:1935151
Synonyms
9830124P08Rik
Feature Type
protein coding gene
Genetic Map
Chromosome 1
32.31 cM, cytoband C1-C3
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr1:64029447-64122282 bp, - strand
From VEGA annotation of GRCm38

  92836 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:2751  Vertebrate Homology Class
1 human; 1 mouse; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 2 zebrafish

HCOP human homology predictions: KLF7
Gene Tree: Klf7

Human
homologs
KLF7, Kruppel-like factor 7 (ubiquitous)
Orthology source: HomoloGene, HGNC

IDs:
NCBI Gene ID: 8609
neXtProt AC: NX_O75840

Human Synonyms: UKLF

Human Chr (Location): 2q32; chr2:207074137-207173851 (-)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(6) : Gene trapped(2) Targeted(4)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous null mice die within 3 days of life, showing lack of gastic milk, hypopnea, cyanosis, olfactory bulb hypoplasia, no response to tail clamping, impaired axon projection in the olfactory and visual systems, cerebral cortex and hippocampus, and reduced dendritic branching in the hippocampus.
 
Interactions
Klf7 interacts with 534 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (13 annotations)
Process axon guidance, axonogenesis, ...
Component nucleus
Function DNA binding, metal ion binding, ...
External Resources: FuncBase
Expression
Literature Summary: (15 records)
Data Summary: Results (178)    Tissues (99)    Images (31)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 168
RT-PCR 10
cDNA source data(14)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase klf7    NEW 
Molecular
reagents
All nucleic(17) Genomic(1) cDNA(14) Primer pair(2)
Microarray probesets(9)
Other database
links
VEGA Gene Model OTTMUSG00000013919 (Evidence)
Ensembl Gene Model ENSMUSG00000025959 (Evidence)
Entrez Gene 93691 (Evidence)
DFCI TC1599230, TC1583340, TC1748417
DoTS DT.487977, DT.101407136
NIA Mouse Gene Index U021401
Consensus CDS Project CCDS15003.1
International Mouse Phenotyping Consortium Status Klf7
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000013919 VEGA Gene Model | MGI Sequence Detail 92836 C57BL/6J ±  kb
transcript OTTMUST00000033149 VEGA | MGI Sequence Detail 7662 Not Applicable 
polypeptide OTTMUSP00000014823 VEGA | MGI Sequence Detail 301 Not Applicable 

For the selected sequences
All sequences(58) RefSeq(12) UniProt(5)
Polymorphisms
SNPs within 2kb(590 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR007087 Zinc finger, C2H2
InterPro IPR015880 Zinc finger, C2H2-like
InterPro IPR013087 Zinc finger C2H2-type/integrase DNA-binding domain
Protein Ontology PR:000009367 krueppel-like factor 7
References
(Earliest) J:69467 Laub F, et al., Developmental expression of mouse Kruppel-like transcription factor KLF7 suggests a potential role in neurogenesis. Dev Biol. 2001 May 15;233(2):305-18
(Latest) J:191803 Schuettpelz LG, et al., Kruppel-like factor 7 overexpression suppresses hematopoietic stem and progenitor cell function. Blood. 2012 Oct 11;120(15):2981-9
All references(49)
Other
accession IDs
MGI:2445036

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
06/23/2015
MGI 5.22
The Jackson Laboratory