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Klf7 Gene Detail
Summary
  • Symbol
    Klf7
  • Name
    Kruppel-like factor 7 (ubiquitous)
  • Synonyms
    9830124P08Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1935151
    NCBI Gene: 93691
  • Gene Overview
    MyGene.info: KLF7
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr1:64029447-64122282 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      92836 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 1, 32.31 cM, cytoband C1-C3
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    KLF7, Kruppel like factor 7
  • Vertebrate Orthologs
    10
  • Human Ortholog
    KLF7, Kruppel like factor 7
    Orthology source: HomoloGene, HGNC
  • Synonyms
    UKLF
  • Links
    NCBI Gene ID: 8609
    neXtProt AC: NX_O75840
    UniProt: O75840

  • Chr Location
    2q33.3; chr2:207074137-207173851 (-)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 2751
    1 human;1 mouse;1 chimpanzee;1 cattle;1 dog;1 chicken;2 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: KLF7
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    25 phenotypes from 2 alleles in 2 genetic backgrounds
    19 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous null mice die within 3 days of life, showing lack of gastic milk, hypopnea, cyanosis, olfactory bulb hypoplasia, no response to tail clamping, impaired axon projection in the olfactory and visual systems, cerebral cortex and hippocampus, and reduced dendritic branching in the hippocampus.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic OTTMUSG00000013919 VEGA Gene Model | MGI Sequence Detail 92836 C57BL/6J ±  kb
    transcript OTTMUST00000033149 VEGA | MGI Sequence Detail 7662 Not Applicable  
    polypeptide OTTMUSP00000014823 VEGA | MGI Sequence Detail 301 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      589 from dbSNP Build 142
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 18
      Genomic 1
      cDNA 14
      Primer pair 2
      Other 1

      Microarray probesets 9
    Other
    Accession IDs
    less
    MGI:2445036
    References
    more
    • Summaries
      All 54
      Developmental Gene Expression 17
      Gene Ontology 5
      Phenotypes 19
    • Earliest
      J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
    • Latest
      J:236599 Dickinson ME, et al., High-throughput discovery of novel developmental phenotypes. Nature. 2016 Sep 14;537(7621):508-514

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
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    last database update
    05/08/2018
    MGI 6.12
    The Jackson Laboratory