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Klf7
Gene Detail
 Symbol
Name
ID
Klf7
Kruppel-like factor 7 (ubiquitous)
MGI:1935151
Synonyms 9830124P08Rik
Feature Type protein coding gene
Genetic Map
Chromosome 1
32.31 cM, cytoband C1-C3
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr1:64029447-64122282 bp, - strand
From VEGA annotation of GRCm38

  92836 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:2751  Vertebrate Homology Class
1 human; 1 mouse; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 2 zebrafish

Gene Tree: Klf7

Human
homologs
Human Homolog KLF7, Kruppel-like factor 7 (ubiquitous)
NCBI Gene ID 8609
neXtProt AC  NX_O75840
Human Synonyms  UKLF
Human Chr (Location)  2q32; chr2:207074137-207167246 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(6) : Gene trapped(2) Targeted(4)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous null mice die within 3 days of life, showing lack of gastic milk, hypopnea, cyanosis, olfactory bulb hypoplasia, no response to tail clamping, impaired axon projection in the olfactory and visual systems, cerebral cortex and hippocampus, and reduced dendritic branching in the hippocampus.
 
Interactions
Klf7 interacts with 535 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (13 annotations)
Process axon guidance, axonogenesis, ...
Component nucleus
Function DNA binding, metal ion binding, ...
External Resources: FuncBase
Expression
Literature Summary: (15 records)
Data Summary: Results (187)    Tissues (106)    Images (31)
Theiler Stages: 2, 3, 4, 5, 17, 19, 21, 23, 28
Assay TypeResults
RNA in situ 170
RT-PCR 17
cDNA source data(14)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(17) Genomic(1) cDNA(14) Primer pair(2)
Microarray probesets(9)
Other database
links
VEGA Gene ModelOTTMUSG00000013919 (Evidence)
Ensembl Gene ModelENSMUSG00000025959 (Evidence)
Entrez Gene93691 (Evidence)
DFCITC1583340, TC1599230, TC1748417
DoTSDT.101407136, DT.487977
NIA Mouse Gene IndexU021401
Consensus CDS ProjectCCDS15003.1
International Mouse Knockout Project StatusKlf7
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000013919 VEGA Gene Model | MGI Sequence Detail 92836 C57BL/6J ±  kb
transcript OTTMUST00000033149 VEGA | MGI Sequence Detail 7664 Not Applicable 
polypeptide OTTMUSP00000014823 VEGA | MGI Sequence Detail 297 Not Applicable 

For the selected sequences
All sequences(64) RefSeq(14) UniProt(7)
Polymorphisms SNPs within 2kb(590 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR007087 Zinc finger, C2H2
InterPro IPR015880 Zinc finger, C2H2-like
InterPro IPR013087 Zinc finger C2H2-type/integrase DNA-binding domain
Protein Ontology PR:000009367 krueppel-like factor 7
References (Earliest) J:69467 Laub F, et al., Developmental expression of mouse Kruppel-like transcription factor KLF7 suggests a potential role in neurogenesis. Dev Biol. 2001 May 15;233(2):305-18
(Latest) J:191803 Schuettpelz LG, et al., Kruppel-like factor 7 overexpression suppresses hematopoietic stem and progenitor cell function. Blood. 2012 Oct 11;120(15):2981-9
All references(49)
Other
accession IDs
MGI:2445036

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/23/2014
MGI 5.19
The Jackson Laboratory