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Mllt6 Gene Detail
Summary
  • Symbol
    Mllt6
  • Name
    myeloid/lymphoid or mixed-lineage leukemia; translocated to, 6
  • Synonyms
    Af17
  • Feature Type
    protein coding gene
  • IDs
    MGI:1935145
    NCBI Gene: 246198
Location & Maps
more
  • Sequence Map
    Chr11:97663414-97685463 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      22050 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 11, 61.05 cM
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    MLLT6, MLLT6, PHD finger domain containing
  • Vertebrate Orthologs
    9
  • Human Ortholog
    MLLT6, MLLT6, PHD finger domain containing
    Orthology source: HomoloGene, HGNC
  • Synonyms
    AF17
  • Links
    NCBI Gene ID: 4302
    neXtProt AC: NX_P55198

  • Chr Location
    17q12; chr17:38705620-38729803 (+)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    15 phenotype references
  • All Mutations and Alleles
    128
  • Gene trapped
    126
  • Targeted
    2
  • Genomic Mutations
    1 involving Mllt6
  • Incidental Mutations
Mice homozygous for a gene trap allele exhibit no abnormal phenotype.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000002741 VEGA Gene Model | MGI Sequence Detail 22050 C57BL/6J ±  kb
transcript OTTMUST00000014167 VEGA | MGI Sequence Detail 7206 Not Applicable  
polypeptide OTTMUSP00000006581 VEGA | MGI Sequence Detail 1109 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    65 from dbSNP Build 142
Protein
Information
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  • UniProt
    5 Sequences
  • InterPro Domains
    IPR011011 Zinc finger, FYVE/PHD-type
    IPR019787 Zinc finger, PHD-finger
    IPR001965 Zinc finger, PHD-type
    IPR019786 Zinc finger, PHD-type, conserved site
    IPR013083 Zinc finger, RING/FYVE/PHD-type
Molecular
Reagents
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  • All nucleic 93
    cDNA 91
    Primer pair 1
    Other 1

    Microarray probesets 5
Other
Accession IDs
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MGI:2144108
References
more
  • Summaries
    All 34
    Developmental Gene Expression 4
    Gene Ontology 1
    Phenotypes 15
  • Earliest
    J:79790 Kleiter N, et al., Mutagenic transgene insertion into a region of high gene density and multiple linkage disruptions on mouse chromosome 11. Cytogenet Genome Res. 2002;97(1-2):100-5
  • Latest
    J:222358 Chen L, et al., Af17 deficiency increases sodium excretion and decreases blood pressure. J Am Soc Nephrol. 2011 Jun;22(6):1076-86

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/29/2016
MGI 6.06
The Jackson Laboratory