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Mllt6 Gene Detail
Summary
  • Symbol
    Mllt6
  • Name
    myeloid/lymphoid or mixed-lineage leukemia; translocated to, 6
  • Synonyms
    Af17
  • Feature Type
    protein coding gene
  • IDs
    MGI:1935145
    NCBI Gene: 246198
  • Alliance
  • Transcription Start Sites
    6 TSS
Location &
Maps
more
  • Sequence Map
    Chr11:97663412-97685461 bp, + strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 11, 61.05 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    65 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1935145
protein coding gene Chr11:97663412-97685463 (+)
129S1/SvImJ MGP_129S1SvImJ_G0019035
protein coding gene Chr11:100117504-100141214 (+)
A/J MGP_AJ_G0019003
protein coding gene Chr11:95985627-96007528 (+)
AKR/J MGP_AKRJ_G0018973
protein coding gene Chr11:98965555-98987493 (+)
BALB/cJ MGP_BALBcJ_G0018976
protein coding gene Chr11:96458211-96508542 (+)
C3H/HeJ MGP_C3HHeJ_G0018790
protein coding gene Chr11:99080786-99106465 (+)
C57BL/6NJ MGP_C57BL6NJ_G0019428
protein coding gene Chr11:103203747-103231517 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0017059
protein coding gene Chr11:93440257-93462729 (+)
CAST/EiJ MGP_CASTEiJ_G0018343
protein coding gene Chr11:99935260-99975673 (+)
CBA/J MGP_CBAJ_G0018761
protein coding gene Chr11:107468696-107494599 (+)
DBA/2J MGP_DBA2J_G0018869
protein coding gene Chr11:95525035-95558747 (+)
FVB/NJ MGP_FVBNJ_G0018858
protein coding gene Chr11:95030596-95052855 (+)
LP/J MGP_LPJ_G0018939
protein coding gene Chr11:100616484-100644508 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0018885
protein coding gene Chr11:107309894-107334077 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0019468
protein coding gene Chr11:99266409-99290656 (+)
PWK/PhJ MGP_PWKPhJ_G0018115
protein coding gene Chr11:96515182-96544627 (+)
SPRET/EiJ MGP_SPRETEiJ_G0017905
protein coding gene Chr11:98986696-99008981 (+)
WSB/EiJ MGP_WSBEiJ_G0018393
protein coding gene Chr11:99160860-99197884 (+)



Homology
more
  • Human Ortholog
    MLLT6, MLLT6, PHD finger containing
  • Vertebrate Orthologs
    9
  • Human Ortholog
    MLLT6, MLLT6, PHD finger containing
    Orthology source: HomoloGene, HGNC
  • Synonyms
    AF17
  • Links
    NCBI Gene ID: 4302
    neXtProt AC: NX_P55198
    UniProt: P55198

  • Chr Location
    17q12; chr17:38705620-38729803 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    3 phenotypes from 2 alleles in 2 genetic backgrounds
    17 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a gene trap allele exhibit no abnormal phenotype.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 246198 NCBI Gene Model | MGI Sequence Detail 22050 C57BL/6J ±  kb
transcript NM_139311 RefSeq | MGI Sequence Detail 7271 C57BL/6  
polypeptide NP_647472 RefSeq | MGI Sequence Detail 1079 C57BL/6  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 97
    cDNA 92
    Primer pair 3
    Other 2

    Microarray probesets 5
Other
Accession IDs
less
MGI:2144108
References
more
  • Summaries
    All 42
    Developmental Gene Expression 4
    Gene Ontology 2
    Phenotypes 17
  • Earliest
    J:56548 Zheng B, et al., Engineering a mouse balancer chromosome. Nat Genet. 1999 Aug;22(4):375-8
  • Latest
    J:222358 Chen L, et al., Af17 deficiency increases sodium excretion and decreases blood pressure. J Am Soc Nephrol. 2011 Jun;22(6):1076-86

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources
Funding Information
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last database update
10/15/2019
MGI 6.14
The Jackson Laboratory