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Smarca5 Gene Detail
Summary
  • Symbol
    Smarca5
  • Name
    SNF2 related chromatin remodeling ATPase 5
  • Synonyms
    4933427E24Rik, D030040M08Rik, D330027N15Rik, MommeD4, Snf2h
  • Feature Type
    protein coding gene
  • IDs
    MGI:1935129
    NCBI Gene: 93762
  • Alliance
    genome feature page
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr8:81426572-81466088 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 8, 38.41 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    696 from dbSNP Build 142
  • Strain Annotations
    17
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1935129
 protein coding gene Chr8:81425136-81466126 (-)
129S1/SvImJ ENSMUSG00200022493
 protein coding gene Chr8:75789377-75830364 (-)
A/J ENSMUSG00195016004
 protein coding gene Chr8:76136760-76177762 (-)
AKR/J ENSMUSG00220021118
 protein coding gene Chr8:76222353-76263314 (-)
BALB/cJ ENSMUSG00180016878
 protein coding gene Chr8:75987807-76028814 (-)
C3H/HeJ ENSMUSG00175009820
 protein coding gene Chr8:76066880-76107870 (-)
C57BL/6NJ ENSMUSG00215013043
 protein coding gene Chr8:75703485-75744485 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0031256
 protein coding gene Chr8:72192827-72233157 (-)
CAST/EiJ ENSTCUG00005032912
 protein coding gene Chr8:75611954-75653934 (-)
CBA/J ENSMUSG00210019921
 protein coding gene Chr8:76058988-76099977 (-)
DBA/2J ENSMUSG00185034170
 protein coding gene Chr8:82168187-82209180 (-)
FVB/NJ ENSMUSG00205027746
 protein coding gene Chr8:75134606-75175796 (-)
JF1/MsJ no annotation
LP/J ENSMUSG00230026957
 protein coding gene Chr8:85786405-85827394 (-)
NOD/ShiLtJ ENSMUSG00190021979
 protein coding gene Chr8:76105121-76146077 (-)
NZO/HlLtJ ENSMUSG00225022941
 protein coding gene Chr8:89167410-89208362 (-)
PWK/PhJ no annotation
SPRET/EiJ ENSMSPG00010021192
 protein coding gene Chr8:77704230-77746131 (-)
WSB/EiJ ENSIUOG00005015068
 protein coding gene Chr8:76867863-76908735 (-)



Homology
more
  • Human Ortholog
    SMARCA5, SNF2 related chromatin remodeling ATPase 5
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    SMARCA5, SNF2 related chromatin remodeling ATPase 5
  • Synonyms
    hISWI, hSNF2H, ISWI, SNF2H, WCRF135
  • Links
    NCBI Gene ID: 8467
    UniProt: O60264

  • Chr Location
    4q31.21; chr4:143513445-143557486 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    10 phenotypes from 3 alleles in 2 genetic backgrounds
    1 phenotype from multigenic genotypes
    60 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous mutant mice die during early embryonic development.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    110
  • GO References
    26
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    887
  • Tissues
    233
  • cDNA Data
    21
  • Literature Summary
    24
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 93762 NCBI Gene Model | MGI Sequence Detail 39517 C57BL/6J ±  kb
    transcript NM_053124 RefSeq | MGI Sequence Detail 4658 C57BL/6  
    polypeptide Q91ZW3 UniProt | EBI | MGI Sequence Detail 1051 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 26
      cDNA 22
      Primer pair 4
      Antibodies 3

      Microarray probesets 7
    Other
    Accession IDs
    less
    MGI:1918447, MGI:2441934, MGI:2443329, MGI:3586540
    References
    more
    • Summaries
      All 136
      Developmental Gene Expression 24
      Gene Ontology 26
      Phenotypes 60
    • Earliest
      J:13049 Gruneberg H, Genetical studies on the skeleton of the mouse. XVIII. Three genes for syndactylism. J Genet. 1956;54(1):113-145
    • Latest
      J:386270 Xu J, et al., SMARCA5 Cooperates With RSF1 to Promote Pathological Glycolysis and Chondrocyte Dysfunction in Osteoarthritis Through ATPase-Dependent Chromatin Regulation. FASEB J. 2025 Dec 31;39(24):e71324
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/01/2026
    MGI 6.24     		The Jackson Laboratory