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Amn
Gene Detail
Symbol

Name
ID
Amn
amnionless
MGI:1934943
Synonyms
5033428N14Rik
Feature Type
protein coding gene
Genetic Map
Chromosome 12
60.94 cM
Detailed Genetic Map ± 1 cM


Mapping data(5)
Sequence Map
Chr12:111271111-111276426 bp, + strand
From NCBI annotation of GRCm38

  5316 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:12804  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: AMN
Gene Tree: Amn

Human
homologs
AMN, amnion associated transmembrane protein
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 81693
neXtProt AC: NX_Q9BXJ7

Human Synonyms: amnionless, PRO1028

Human Chr (Location): 14q32.3; chr14:102922548-102930847 (+)  GRCh38.p2

Disease Associations: (1) Diseases Associated with Human AMN

Mutations,
alleles, and
phenotypes
All mutations/alleles(6) : Chemically induced (ENU)(1) Targeted(4) Transgenic(1)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Homozygous mutation of this gene results in embryonic growth arrest between the mid and late streak stages of gastrulation and abnormal ectoderm formation, followed by death. Generation of middle primitive streak derivatives is impaired, leading to absence of mesoderm and somites.
 
Phenotype Images(8)
Interactions
Amn interacts with 34 markers (Mir7-1, Mir26a-1, Mir26a-2, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (14 annotations)
Process cobalamin transport, excretion, ...
Component apical part of cell, apical plasma membrane, ...
Function receptor binding
External Resources: FuncBase
Expression
Literature Summary: (9 records)
Data Summary: Results (14)    Tissues (7)    Images (12)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 5
RNA in situ 9
cDNA source data(34)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: ZFIN amn    NEW 
Molecular
reagents
All nucleic(40) Genomic(3) cDNA(37)
Microarray probesets(3)
Other database
links
Ensembl Gene Model ENSMUSG00000021278 (Evidence)
Entrez Gene 93835 (Evidence)
UniGene 197639
DFCI TC1579838
DoTS DT.488777, DT.94172566
NIA Mouse Gene Index U014426
Consensus CDS Project CCDS36564.1
International Mouse Phenotyping Consortium Status Amn
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 93835 NCBI Gene Model | MGI Sequence Detail 5316 C57BL/6J ±  kb
transcript NM_033603 RefSeq | MGI Sequence Detail 1685 129X1/SvJ 
polypeptide Q99JB7 UniProt | EBI | MGI Sequence Detail 458 Not Applicable 

For the selected sequences
All sequences(19) RefSeq(2) UniProt(1)
Polymorphisms
SNPs within 2kb(65 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR026112 Amnionless
Protein Ontology PR:000003996 protein amnionless
Graphical View of Protein Domain Structure
References
(Earliest) J:34163 Wang X, et al., A candidate gene for the amnionless gastrulation stage mouse mutation encodes a TRAF-related protein. Dev Biol. 1996 Jul 10;177(1):274-90
(Latest) J:222397 Kulinski TM, et al., Imprinted expression in cystic embryoid bodies shows an embryonic and not an extra-embryonic pattern. Dev Biol. 2015 Jun 15;402(2):291-305
All references(41)
Other
accession IDs
MGI:1914845, MGI:2144974

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
08/25/2015
MGI 6.0
The Jackson Laboratory