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Amn
Gene Detail
 Symbol
Name
ID
Amn
amnionless
MGI:1934943
Synonyms 5033428N14Rik
Feature Type protein coding gene
Genetic Map
Chromosome 12
60.94 cM
Detailed Genetic Map ± 1 cM


Mapping data(5)
Sequence Map
Chr12:111271111-111276426 bp, + strand
From NCBI annotation of GRCm38

  5316 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:12804  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 chicken; 1 western clawed frog; 1 zebrafish

Gene Tree: Amn

Human
homologs
Human Homolog AMN, amnion associated transmembrane protein
NCBI Gene ID 81693
neXtProt AC  NX_Q9BXJ7
Human Synonyms  amnionless, PRO1028
Human Chr (Location)  14q32.3; chr14:102922656-102930842 (+)  GRCh38
Disease Associations  (1) Diseases Associated with Human AMN
Mutations,
alleles, and
phenotypes
All mutations/alleles(5) : Targeted(4) Transgenic(1)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous mutation of this gene results in embryonic growth arrest between the mid and late streak stages of gastrulation and abnormal ectoderm formation, followed by death. Generation of middle primitive streak derivatives is impaired, leading to absence of mesoderm and somites.
 
Interactions
Amn interacts with 34 markers (Mir7-1, Mir26a-1, Mir26a-2, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (14 annotations)
Process cobalamin transport, excretion, ...
Component apical part of cell, apical plasma membrane, ...
Function receptor binding
External Resources: FuncBase
Expression
Literature Summary: (7 records)
Data Summary: Results (14)    Tissues (7)    Images (2)
Theiler Stages: 5, 6, 7, 8, 9, 11, 13
Assay TypeResults
Immunohistochemistry 5
RNA in situ 9
cDNA source data(34)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(40) Genomic(3) cDNA(37)
Microarray probesets(3)
Other database
links
Ensembl Gene ModelENSMUSG00000021278 (Evidence)
Entrez Gene93835 (Evidence)
UniGene197639
DFCITC1579838
DoTSDT.488777, DT.94172566
NIA Mouse Gene IndexU014426
Consensus CDS ProjectCCDS36564.1
International Mouse Knockout Project StatusAmn
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 93835 NCBI Gene Model | MGI Sequence Detail 5316 C57BL/6J ±  kb
transcript NM_033603 RefSeq | MGI Sequence Detail 1685 129X1/SvJ 
polypeptide Q99JB7 UniProt | EBI | MGI Sequence Detail 458 Not Applicable 

For the selected sequences
All sequences(19) RefSeq(2) UniProt(1)
Polymorphisms SNPs within 2kb(65 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR026112 Amnionless
Protein Ontology PR:000003996 protein amnionless
Graphical View of Protein Domain Structure
References (Earliest) J:34163 Wang X, et al., A candidate gene for the amnionless gastrulation stage mouse mutation encodes a TRAF-related protein. Dev Biol. 1996 Jul 10;177(1):274-90
(Latest) J:173534 Skarnes WC, et al., A conditional knockout resource for the genome-wide study of mouse gene function. Nature. 2011 Jun 16;474(7351):337-42
All references(38)
Other
accession IDs
MGI:1914845, MGI:2144974

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
09/09/2014
MGI 5.19
The Jackson Laboratory