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Ifitm5 Gene Detail
Summary
  • Symbol
    Ifitm5
  • Name
    interferon induced transmembrane protein 5
  • Synonyms
    1110003J06Rik, Bril, fragilis4, Hrmp1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1934923
    NCBI Gene: 73835
  • Alliance
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr7:140948962-140950239 bp, - strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 7, 86.17 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    51 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1934923
protein coding gene Chr7:140948958-140950291 (-)
129S1/SvImJ MGP_129S1SvImJ_G0033202
protein coding gene Chr7:146086423-146087699 (-)
A/J MGP_AJ_G0033184
protein coding gene Chr7:141932859-141934135 (-)
AKR/J MGP_AKRJ_G0033116
protein coding gene Chr7:145823464-145824740 (-)
BALB/cJ MGP_BALBcJ_G0033185
protein coding gene Chr7:141660587-141661863 (-)
C3H/HeJ MGP_C3HHeJ_G0032899
protein coding gene Chr7:145580562-145581838 (-)
C57BL/6NJ MGP_C57BL6NJ_G0033696
protein coding gene Chr7:151431842-151433118 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0030669
protein coding gene Chr7:143143585-143144869 (-)
CAST/EiJ MGP_CASTEiJ_G0032229
protein coding gene Chr7:137880857-137882135 (-)
CBA/J MGP_CBAJ_G0032871
protein coding gene Chr7:156558751-156560027 (-)
DBA/2J MGP_DBA2J_G0033024
protein coding gene Chr7:139870906-139872182 (-)
FVB/NJ MGP_FVBNJ_G0032976
protein coding gene Chr7:139783578-139784854 (-)
LP/J MGP_LPJ_G0033118
protein coding gene Chr7:147590877-147592153 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0033009
protein coding gene Chr7:157222978-157224254 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0033716
protein coding gene Chr7:144807624-144808900 (-)
PWK/PhJ MGP_PWKPhJ_G0031934
protein coding gene Chr7:133143111-133144387 (-)
SPRET/EiJ MGP_SPRETEiJ_G0031780
protein coding gene Chr7:131623674-131624951 (-)
WSB/EiJ MGP_WSBEiJ_G0032340
protein coding gene Chr7:145729205-145730481 (-)



Homology
more
  • Human Ortholog
    IFITM5, interferon induced transmembrane protein 5
  • Vertebrate Orthologs
    8
  • Human Ortholog
    IFITM5, interferon induced transmembrane protein 5
    Orthology source: HomoloGene, HGNC
  • Synonyms
    BRIL, DSPA1, fragilis4, Hrmp1, OI5
  • Links
    NCBI Gene ID: 387733
    neXtProt AC: NX_A6NNB3
    UniProt: A6NNB3

  • Chr Location
    11p15.5; chr11:298200-299526 (-)  GRCh38.p7

Human Diseases
more
  • Diseases
    1 with human IFITM5 associations

Human Disease Mouse Models
      
IDs
View 1 "NOT" model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    48 phenotypes from 3 alleles in 4 genetic backgrounds
    12 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygous null mice exhbit smaller skeletons, partial prenatal and postnatal lethality, and small litter sizes. Mice that survive to adulthood still exhibit shorter bones but other skeletal defects are no longer seen.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 73835 NCBI Gene Model | MGI Sequence Detail 1278 C57BL/6J ±  kb
    transcript NM_053088 RefSeq | MGI Sequence Detail 733 C57BL/6  
    polypeptide O88728 UniProt | EBI | MGI Sequence Detail 134 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      1 Sequence
    • InterPro Domains
      IPR007593 CD225/Dispanin family
    Molecular
    Reagents
    less
    • All nucleic 18
      cDNA 17
      Primer pair 1

      Microarray probesets 2
    Other
    Accession IDs
    less
    MGI:1921085, MGI:2142220
    References
    more
    • Summaries
      All 39
      Developmental Gene Expression 7
      Diseases 1
      Gene Ontology 8
      Phenotypes 12
    • Earliest
      J:65007 Cattanach BM, et al., Two imprinted gene mutations: three phenotypes. Hum Mol Genet. 2000 Sep 22;9(15):2263-73
    • Latest
      J:255349 Rauch F, et al., Crispr-Cas9 engineered osteogenesis imperfecta type V leads to severe skeletal deformities and perinatal lethality in mice. Bone. 2018 Feb;107:131-142

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    11/13/2018
    MGI 6.13
    The Jackson Laboratory