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Ifitm5 Gene Detail
Summary
  • Symbol
    Ifitm5
  • Name
    interferon induced transmembrane protein 5
  • Synonyms
    1110003J06Rik, Bril, fragilis4, Hrmp1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1934923
    NCBI Gene: 73835
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr7:140948958-140950291 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      1334 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 7, 86.17 cM
  • Mapping Data
    3 experiments
Homology
more
  • Human Ortholog
    IFITM5, interferon induced transmembrane protein 5
  • Vertebrate Orthologs
    8
  • Human Ortholog
    IFITM5, interferon induced transmembrane protein 5
    Orthology source: HomoloGene, HGNC
  • Synonyms
    BRIL, DSPA1, fragilis4, Hrmp1, OI5
  • Links
    NCBI Gene ID: 387733
    neXtProt AC: NX_A6NNB3
    UniProt: A6NNB3

  • Chr Location
    11p15.5; chr11:298200-299526 (-)  GRCh38.p7

Human Diseases
more
  • Diseases
    1 with human IFITM5 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    15 phenotypes from 1 allele in 1 genetic background
    10 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous null mice exhbit smaller skeletons, partial prenatal and postnatal lethality, and small litter sizes. Mice that survive to adulthood still exhibit shorter bones but other skeletal defects are no longer seen.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
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    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic OTTMUSG00000060379 VEGA Gene Model | MGI Sequence Detail 1334 C57BL/6J ±  kb
    transcript OTTMUST00000147744 VEGA | MGI Sequence Detail 765 Not Applicable  
    polypeptide OTTMUSP00000076860 VEGA | MGI Sequence Detail 134 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      52 from dbSNP Build 142
    Protein
    Information
    less
    • UniProt
      1 Sequence
    • InterPro Domains
      IPR007593 CD225/Dispanin family
    Molecular
    Reagents
    less
    • All nucleic 17
      cDNA 16
      Primer pair 1

      Microarray probesets 2
    Other
    Accession IDs
    less
    MGI:1921085, MGI:2142220
    References
    more
    • Summaries
      All 37
      Developmental Gene Expression 6
      Gene Ontology 7
      Phenotypes 10
    • Earliest
      J:65007 Cattanach BM, et al., Two imprinted gene mutations: three phenotypes. Hum Mol Genet. 2000 Sep 22;9(15):2263-73
    • Latest
      J:255349 Rauch F, et al., Crispr-Cas9 engineered osteogenesis imperfecta type V leads to severe skeletal deformities and perinatal lethality in mice. Bone. 2018 Feb;107:131-142

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    Funding Information
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    last database update
    06/12/2018
    MGI 6.12
    The Jackson Laboratory