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Ifitm5 Gene Detail
Summary
  • Symbol
    Ifitm5
  • Name
    interferon induced transmembrane protein 5
  • Synonyms
    1110003J06Rik, Bril, fragilis4, Hrmp1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1934923
    NCBI Gene: 73835
Location & Maps
more
  • Sequence Map
    Chr7:140948962-140950239 bp, - strand
  • From NCBI annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      1278 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 7, 86.17 cM
  • Mapping Data
    3 experiments
Homology
more
  • Human Ortholog
    IFITM5, interferon induced transmembrane protein 5
  • Vertebrate Orthologs
    8
  • Human Ortholog
    IFITM5, interferon induced transmembrane protein 5
    Orthology source: HomoloGene, HGNC
  • Synonyms
    BRIL, DSPA1, fragilis4, Hrmp1, OI5
  • Links
    NCBI Gene ID: 387733
    neXtProt AC: NX_A6NNB3

  • Chr Location
    11p15.5; chr11:298200-299526 (-)  GRCh38.p2

Human Diseases
more
  • Diseases
    1 with human IFITM5 associations

Human Disease Mouse Models
       Osteogenesis Imperfecta, Type V; OI5   OMIM: 610967
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    15 phenotypes from 1 allele in 1 genetic background
    11 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    11
  • Gene trapped
    5
  • Radiation induced
    1
  • Targeted
    5
  • Genomic Mutations
    2 involving Ifitm5
  • Incidental Mutations
Homozygous null mice exhbit smaller skeletons, partial prenatal and postnatal lethality, and small litter sizes. Mice that survive to adulthood still exhibit shorter bones but other skeletal defects are no longer seen.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 73835 NCBI Gene Model | MGI Sequence Detail 1278 C57BL/6J ±  kb
transcript NM_053088 RefSeq | MGI Sequence Detail 734 Not Specified  
polypeptide O88728 UniProt | EBI | MGI Sequence Detail 134 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    51 from dbSNP Build 142
Protein
Information
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  • UniProt
    1 Sequence
  • Protein Ontology
    PR:000032403 interferon-induced transmembrane protein 5
  • InterPro Domains
    IPR007593 CD225/Dispanin family
Molecular
Reagents
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  • All nucleic 17
    cDNA 16
    Primer pair 1

    Microarray probesets 2
Other
Accession IDs
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MGI:1921085, MGI:2142220
References
more
  • Summaries
    All 32
    Developmental Gene Expression 5
    Gene Ontology 7
    Phenotypes 11
  • Earliest
    J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
  • Latest
    J:233366 Lietman CD, et al., A transgenic mouse model of OI type V supports a neomorphic mechanism of the IFITM5 mutation. J Bone Miner Res. 2015 Mar;30(3):489-98

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
09/27/2016
MGI 6.05
The Jackson Laboratory