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Ifitm5
Gene Detail
Symbol

Name
ID
Ifitm5
interferon induced transmembrane protein 5
MGI:1934923
Synonyms
1110003J06Rik, Bril, fragilis4, Hrmp1
Feature Type
protein coding gene
Genetic Map
Chromosome 7
86.17 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr7:140948963-140950239 bp, - strand
From Ensembl annotation of GRCm38

  1277 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:14210  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 chicken; 1 western clawed frog

HCOP human homology predictions: IFITM5
Protein SuperFamily: interferon-induced transmembrane protein
Gene Tree: Ifitm5

Human
homologs
IFITM5, interferon induced transmembrane protein 5
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 387733
neXtProt AC: NX_A6NNB3

Human Synonyms: BRIL, DSPA1, fragilis4, Hrmp1, OI5

Human Chr (Location): 11p15.5; chr11:298200-299526 (-)  GRCh38.p2

Disease Associations: (1) Diseases Associated with Human IFITM5

Mutations,
alleles, and
phenotypes
All mutations/alleles(10) : Gene trapped(5) Targeted(5)
Genomic Mutations involving Ifitm5 (1)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous null mice exhbit smaller skeletons, partial prenatal and postnatal lethality, and small litter sizes. Mice that survive to adulthood still exhibit shorter bones but other skeletal defects are no longer seen.
 
Interactions
Ifitm5 interacts with 39 markers (Mir133a-1, Mir133a-2, Mir138-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (14 annotations)
Process bone mineralization, bone morphogenesis, ...
Component integral component of membrane, integral component of plasma membrane, ...
Function molecular_function
External Resources: FuncBase
Expression
Literature Summary: (5 records)
Data Summary: Results (11)    Tissues (11)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 5
RNA in situ 6
cDNA source data(16)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase LOC100498002    NEW 
Molecular
reagents
All nucleic(16) cDNA(16)
Microarray probesets(2)
Other database
links
Ensembl Gene Model ENSMUSG00000025489 (Evidence)
Entrez Gene 73835 (Evidence)
UniGene 389989
DFCI TC1584568
DoTS DT.94353137, DT.489487
NIA Mouse Gene Index U029438
Consensus CDS Project CCDS21993.1
International Mouse Phenotyping Consortium Status Ifitm5
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000025489 Ensembl Gene Model | MGI Sequence Detail 1277 C57BL/6J ±  kb
transcript ENSMUST00000026562 Ensembl | MGI Sequence Detail 708 Not Applicable 
polypeptide ENSMUSP00000026562 Ensembl | MGI Sequence Detail 134 Not Applicable 

For the selected sequences
All sequences(18) RefSeq(2) UniProt(1)
Polymorphisms
SNPs within 2kb(51 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR007593 Interferon-induced transmembrane protein
Protein Ontology PR:000032403 interferon-induced transmembrane protein 5
References
(Earliest) J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
(Latest) J:215966 Hanagata N, et al., Characterization of the osteoblast-specific transmembrane protein IFITM5 and analysis of IFITM5-deficient mice. J Bone Miner Metab. 2011 May;29(3):279-90
All references(34)
Other
accession IDs
MGI:1921085, MGI:2142220

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/21/2015
MGI 5.22
The Jackson Laboratory