About   Help   FAQ
Rnf111
Gene Detail
 Symbol
Name
ID
Rnf111
ring finger 111
MGI:1934919
Synonyms Arkadia
Feature Type protein coding gene
Genetic Map
Chromosome 9
39.53 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr9:70425429-70503725 bp, - strand
From NCBI annotation of GRCm38

  78297 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:9741  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Gene Tree: Rnf111

Human
homologs
Human Homolog RNF111, ring finger protein 111
NCBI Gene ID 54778
neXtProt AC  NX_Q6ZNA4
Human Synonyms  ARK
Human Chr (Location)  15q21; chr15:58987666-59097419 (+)  GRCh38
Alleles
and
phenotypes
All alleles(471) : Gene trapped(469) Targeted(2)
Incidental mutations (data from Mutagenetix , APF )
 
Mutations in this gene cause developmental defects in extraembryonic lineages, resulting in arrested development and lethality around midgestation.
 
Gene Ontology
(GO)
classifications
All GO classifications: (39 annotations)
Process multicellular organismal development, pattern specification process, ...
Component cytoplasm, nucleolus, ...
Function coenzyme F420-0 gamma-glutamyl ligase activity, coenzyme F420-2 alpha-glutamyl ligase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (5 records)
Data Summary: Results (58)    Tissues (56)    Images (6)
Theiler Stages: 17, 18, 21, 22, 23, 28
Assay TypeResults
RNA in situ 54
RT-PCR 4
cDNA source data(16)
External Resources: Allen Institute   GEO   ArrayExpress
Molecular
reagents
All nucleic(18) cDNA(17) Primer pair(1)
Microarray probesets(4)
Other database
links
Ensembl Gene ModelENSMUSG00000032217 (Evidence)
Entrez Gene93836 (Evidence)
DFCITC1576908, TC1588550
DoTSDT.101207935, DT.101271084, DT.101351916, DT.101380058, DT.489504, DT.91386243, DT.97358670
NIA Mouse Gene IndexU031056, U359308
EC6.3.2.-
Consensus CDS ProjectCCDS23321.1
International Mouse Knockout Project StatusRnf111
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 93836 NCBI Gene Model | MGI Sequence Detail 78297 C57BL/6J ±  kb
transcript NM_033604 RefSeq | MGI Sequence Detail 4880 C57BL/6 
polypeptide Q99ML9 UniProt | EBI | MGI Sequence Detail 989 Not Applicable 

For the selected sequences
All sequences(61) RefSeq(26) UniProt(1)
Polymorphisms SNPs within 2kb(180 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR013083 Zinc finger, RING/FYVE/PHD-type
InterPro IPR001841 Zinc finger, RING-type
Protein Ontology PR:000014067 E3 ubiquitin-protein ligase Arkadia
Graphical View of Protein Domain Structure
References (Earliest) J:68833 Episkopou V, et al., Induction of the mammalian node requires Arkadia function in the extraembryonic lineages. Nature. 2001 Apr 12;410(6830):825-30
(Latest) J:204028 Erker Y, et al., Arkadia, a novel SUMO-targeted ubiquitin ligase involved in PML degradation. Mol Cell Biol. 2013 Jun;33(11):2163-77
All references(44)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
07/15/2014
MGI 5.18
The Jackson Laboratory