About   Help   FAQ
Nucks1 Gene Detail
Summary
  • Symbol
    Nucks1
  • Name
    nuclear casein kinase and cyclin-dependent kinase substrate 1
  • Synonyms
    2700010L10Rik, 8430423A01Rik, Nucks
  • Feature Type
    protein coding gene
  • IDs
    MGI:1934811
    NCBI Gene: 98415
  • Gene Overview
    MyGene.info: NUCKS1
  • Alliance
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr1:131910534-131936321 bp, + strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 1, 57.22 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    65 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1934811
protein coding gene Chr1:131910458-131936321 (.)
129S1/SvImJ MGP_129S1SvImJ_G0016462
protein coding gene Chr1:135354939-135384910 (+)
A/J MGP_AJ_G0016445
protein coding gene Chr1:130350821-130378357 (+)
AKR/J MGP_AKRJ_G0016410
protein coding gene Chr1:134176311-134204094 (+)
BALB/cJ MGP_BALBcJ_G0016405
protein coding gene Chr1:130669579-130697517 (+)
C3H/HeJ MGP_C3HHeJ_G0016231
protein coding gene Chr1:134323934-134351587 (+)
C57BL/6NJ MGP_C57BL6NJ_G0016866
protein coding gene Chr1:140400197-140428880 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0014577
protein coding gene Chr1:123500738-123524250 (+)
CAST/EiJ MGP_CASTEiJ_G0015811
protein coding gene Chr1:133316379-133350319 (+)
CBA/J MGP_CBAJ_G0016203
protein coding gene Chr1:145175726-145204660 (+)
DBA/2J MGP_DBA2J_G0016310
protein coding gene Chr1:129313439-129341411 (+)
FVB/NJ MGP_FVBNJ_G0016309
protein coding gene Chr1:127937335-127963944 (+)
LP/J MGP_LPJ_G0016381
protein coding gene Chr1:136672586-136702864 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0016334
protein coding gene Chr1:150949071-150993249 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0016902
protein coding gene Chr1:133936742-133962483 (+)
PWK/PhJ MGP_PWKPhJ_G0015597
protein coding gene Chr1:128280813-128301598 (+)
SPRET/EiJ MGP_SPRETEiJ_G0015384
protein coding gene Chr1:132884912-132910897 (+)
WSB/EiJ MGP_WSBEiJ_G0015873
protein coding gene Chr1:133924556-133950203 (+)



Homology
more
  • Human Ortholog
    NUCKS1, nuclear casein kinase and cyclin dependent kinase substrate 1
  • Vertebrate Orthologs
    11
  • Human Ortholog
    NUCKS1, nuclear casein kinase and cyclin dependent kinase substrate 1
    Orthology source: HomoloGene, HGNC
  • Synonyms
    JC7, NUCKS
  • Links
    NCBI Gene ID: 64710
    neXtProt AC: NX_Q9H1E3
    UniProt: Q9H1E3

  • Chr Location
    1q32.1; chr1:205712819-205750244 (-)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 23377
    1 human;1 mouse;2 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: NUCKS1
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    16 phenotype references
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000026434 Ensembl Gene Model | MGI Sequence Detail 25788 C57BL/6J ±  kb
transcript ENSMUST00000062264 Ensembl | MGI Sequence Detail 5998 Not Applicable  
polypeptide ENSMUSP00000062576 Ensembl | MGI Sequence Detail 234 Not Applicable  
For the selected sequence
Protein
Information
less
  • UniProt
    2 Sequences
  • Protein Ontology
    PR:000011481 nuclear ubiquitous casein and cyclin-dependent kinase substrate 1
  • InterPro Domains
    IPR026633 Nuclear ubiquitous casein and cyclin-dependent kinase substrate 1
Molecular
Reagents
less
  • All nucleic 13
    cDNA 11
    Primer pair 1
    Other 1

    Microarray probesets 8
Other
Accession IDs
less
MGI:1919821, MGI:2138310, MGI:2138671
References
more
  • Summaries
    All 45
    Developmental Gene Expression 5
    Gene Ontology 6
    Phenotypes 16
  • Earliest
    J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
  • Latest
    J:261884 Poon MW, et al., Inhibition of NUCKS Facilitates Corneal Recovery Following Alkali Burn. Sci Rep. 2017 Jan 20;7:41224

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
11/06/2018
MGI 6.13
The Jackson Laboratory