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Kars Gene Detail
Summary
  • Symbol
    Kars
  • Name
    lysyl-tRNA synthetase
  • Synonyms
    D8Ertd698e, D8Wsu108e, LysRS, mKIAA0070
  • Feature Type
    protein coding gene
  • IDs
    MGI:1934754
    NCBI Gene: 85305
  • Gene Overview
    MyGene.info: KARS
  • Alliance
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr8:111993443-112011323 bp, - strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 8, 58.27 cM, cytoband D3
  • Mapping Data
    6 experiments
Strain
Comparison
more
  • SNPs within 2kb
    257 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1934754
protein coding gene Chr8:111993439-112011354 (-)
129S1/SvImJ MGP_129S1SvImJ_G0034152
protein coding gene Chr8:114834234-114852175 (-)
A/J MGP_AJ_G0034132
protein coding gene Chr8:110145013-110163491 (-)
AKR/J MGP_AKRJ_G0034059
protein coding gene Chr8:113390814-113411017 (-)
BALB/cJ MGP_BALBcJ_G0034126
protein coding gene Chr8:110323210-110340839 (-)
C3H/HeJ MGP_C3HHeJ_G0033837
protein coding gene Chr8:114096676-114115471 (-)
C57BL/6NJ MGP_C57BL6NJ_G0034646
protein coding gene Chr8:118843291-118861588 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0031588
protein coding gene Chr8:103215072-103234154 (-)
CAST/EiJ MGP_CASTEiJ_G0033164
protein coding gene Chr8:113744032-113761601 (-)
CBA/J MGP_CBAJ_G0033810
protein coding gene Chr8:122942066-122960394 (-)
DBA/2J MGP_DBA2J_G0033966
protein coding gene Chr8:109417254-109435623 (-)
FVB/NJ MGP_FVBNJ_G0033909
protein coding gene Chr8:108400143-108419124 (-)
LP/J MGP_LPJ_G0034055
protein coding gene Chr8:114986333-115004116 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0033956
protein coding gene Chr8:125769744-125790501 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0034664
protein coding gene Chr8:113377782-113395515 (-)
PWK/PhJ MGP_PWKPhJ_G0032866
protein coding gene Chr8:109029857-109048491 (-)
SPRET/EiJ MGP_SPRETEiJ_G0032706
protein coding gene Chr8:112031068-112048206 (-)
WSB/EiJ MGP_WSBEiJ_G0033280
protein coding gene Chr8:114060628-114086161 (-)



Homology
more
  • Human Ortholog
    KARS, lysyl-tRNA synthetase
  • Vertebrate Orthologs
    10
  • Human Ortholog
    KARS, lysyl-tRNA synthetase
    Orthology source: HomoloGene, HGNC
  • Synonyms
    CMTRIB, DFNB89, KARS1, KARS2, KRS
  • Links
    NCBI Gene ID: 3735
    neXtProt AC: NX_Q15046
    UniProt: Q15046

  • Chr Location
    16q23.1; chr16:75627724-75647687 (-)  GRCh38.p7

Human Diseases
more
  • Diseases
    2 with human KARS associations

Human Disease Mouse Models
      
IDs
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    4 phenotypes from 1 allele in 1 genetic background
    11 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000031948 Ensembl Gene Model | MGI Sequence Detail 17881 C57BL/6J ±  kb
    transcript ENSMUST00000093120 Ensembl | MGI Sequence Detail 2131 Not Applicable  
    polypeptide ENSMUSP00000090808 Ensembl | MGI Sequence Detail 624 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      7 Sequences
    • EC
    • InterPro Domains
      IPR006195 Aminoacyl-tRNA synthetase, class II
      IPR004364 Aminoacyl-tRNA synthetase, class II (D/K/N)
      IPR034762 Bacterial/eukaryotic lysine-tRNA ligase, class II
      IPR002313 Lysine-tRNA ligase, class II
      IPR018149 Lysyl-tRNA synthetase, class II, C-terminal
      IPR012340 Nucleic acid-binding, OB-fold
      IPR004365 OB-fold nucleic acid binding domain, AA-tRNA synthetase-type
    Molecular
    Reagents
    less
    • All nucleic 18
      cDNA 16
      Primer pair 2

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-34116, MGI:106422, MGI:1277111, MGI:2142434, MGI:2142665, MGI:2142669, MGI:2142671
    References
    more
    • Summaries
      All 47
      Developmental Gene Expression 4
      Gene Ontology 6
      Phenotypes 11
    • Earliest
      J:50869 Ko MSH, et al., Genome-wide mapping of unselected transcripts from extraembryonic tissue of 7.5-day mouse embryos reveals enrichment in the t-complex and under-representation on the X chromosome. Hum Mol Genet. 1998 Nov;7(12):1967-78
    • Latest
      J:236599 Dickinson ME, et al., High-throughput discovery of novel developmental phenotypes. Nature. 2016 Sep 14;537(7621):508-514

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
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    last database update
    11/06/2018
    MGI 6.13
    The Jackson Laboratory