Kars
Gene Detail

Symbol Name ID

Kars lysyl-tRNA synthetase MGI:1934754

Synonyms

D8Ertd698e, D8Wsu108e, LysRS, mKIAA0070

Feature Type

protein coding gene

Genetic Map

Chromosome 8

58.27 cM, cytoband D3
Detailed Genetic Map ± 1 cM


Mapping data(6)

Sequence Map

Chr8:111993440-112011305 bp, - strand From NCBI annotation of GRCm38   17866 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:4053  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Gene Tree: Kars

Human homologs

Human Homolog		KARS, lysyl-tRNA synthetase
NCBI Gene ID		3735
neXtProt AC		NX_Q15046
Human Synonyms		CMTRIB, KARS1, KARS2, KRS
Human Chr (Location)		16q23.1; chr16:75661622-75681585 (-)  GRCh37.p10
Disease Associations		(1) Diseases Associated with Human KARS

Alleles and phenotypes

All alleles(28) : Targeted(2) Gene trapped(26)

Gene Ontology (GO) classifications

All GO classifications: (22 annotations)

Process	diadenosine tetraphosphate biosynthetic process, lysyl-tRNA aminoacylation, ...
Component	aminoacyl-tRNA synthetase multienzyme complex, cytoplasm, ...
Function	amino acid binding, aminoacyl-tRNA ligase activity, ...

This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase

Expression

Literature Summary: (3 records)
Data Summary: Results (109)    Tissues (97)    Images (22)
Theiler Stages: 11, 22, 23

Assay Type	Results
RNA in situ	103
RT-PCR	6

cDNA source data(12)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(15) cDNA(13) Primer pair(2)
Microarray probesets(3)

Other database links

Ensembl Gene Model	ENSMUSG00000031948 (Evidence)
Entrez Gene	85305 (Evidence)
DFCI	TC1571983, TC1729826
DoTS	DT.101385419, DT.101385426, DT.101385429, DT.110876008, DT.496447, DT.55137285, DT.97362532
EC	6.1.1.6
Consensus CDS Project	CCDS40481.1, CCDS52677.1
International Mouse Knockout Project Status	Kars

Sequences

Length	Strain/Species
genomic	85305	NCBI Gene Model | MGI Sequence Detail	17866	C57BL/6J
transcript	NM_001130868	RefSeq | MGI Sequence Detail	2173	Not Specified
polypeptide	Q99MN1	UniProt | EBI | MGI Sequence Detail	595	Not Applicable

All sequences(59) RefSeq(4) UniProt(6)

Polymorphisms

SNPs(120 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR006195	Aminoacyl-tRNA synthetase, class II
InterPro	IPR004364	Aminoacyl-tRNA synthetase, class II (D/K/N)
InterPro	IPR018150	Aminoacyl-tRNA synthetase, class II (D/K/N)-like
InterPro	IPR002313	Lysine-tRNA ligase, class II
InterPro	IPR018149	Lysyl-tRNA synthetase, class II, C-terminal
InterPro	IPR012340	Nucleic acid-binding, OB-fold
InterPro	IPR004365	Nucleic acid binding, OB-fold, tRNA/helicase-type
Protein Ontology	PR:000009241	lysyl-tRNA synthetase

Graphical View of Protein Domain Structure

References

(Earliest) J:50869 Ko MSH, et al., Genome-wide mapping of unselected transcripts from extraembryonic tissue of 7.5-day mouse embryos reveals enrichment in the t-complex and under-representation on the X chromosome. Hum Mol Genet. 1998 Nov;7(12):1967-78
(Latest) J:153498 Diez-Roux G, et al., A high-resolution anatomical atlas of the transcriptome in the mouse embryo. PLoS Biol. 2011;9(1):e1000582
All references(41)

Other accession IDs

MGD-MRK-34116, MGI:106422, MGI:1277111, MGI:2142434, MGI:2142665, MGI:2142669, MGI:2142671