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Kars Gene Detail
Summary
  • Symbol
    Kars
  • Name
    lysyl-tRNA synthetase
  • Synonyms
    D8Ertd698e, D8Wsu108e, LysRS, mKIAA0070
  • Feature Type
    protein coding gene
  • IDs
    MGI:1934754
    NCBI Gene: 85305
  • Gene Overview
    MyGene.info: KARS
Location & Maps
more
  • Sequence Map
    Chr8:111993440-112011323 bp, - strand
  • From Ensembl annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      17884 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 8, 58.27 cM, cytoband D3
  • Detailed Genetic Map ± 1 cM
  • Mapping Data
    6 experiments
Homology
more
  • Human Ortholog
    KARS, lysyl-tRNA synthetase
  • Vertebrate Orthologs
    10
  • Human Ortholog
    KARS, lysyl-tRNA synthetase
    Orthology source: HGNC, HomoloGene
  • Synonyms
    CMTRIB, DFNB89, KARS1, KARS2, KRS
  • Links
    NCBI Gene ID: 3735
    neXtProt AC: NX_Q15046

  • Chr Location
    16q23.1; chr16:75627724-75647687 (-)  GRCh38.p2

Human Diseases
more
  • Diseases
    2 with human KARS associations

Human Disease Mouse Models
       Charcot-Marie-Tooth Disease, Recessive Intermediate B; CMTRIB   OMIM: 613641
Deafness, Autosomal Recessive 89; DFNB89   OMIM: 613916
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    3 phenotypes from 1 allele in 1 genetic background
    9 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryogenesis
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
tumorigenesis
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000031948 Ensembl Gene Model | MGI Sequence Detail 17884 C57BL/6J ±  kb
transcript ENSMUST00000164470 Ensembl | MGI Sequence Detail 2188 Not Applicable  
polypeptide ENSMUSP00000126268 Ensembl | MGI Sequence Detail 624 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    257 from dbSNP Build 142
Protein
Information
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  • UniProt
    6 Sequences
  • Protein Ontology
    PR:000009241 lysine--tRNA ligase
  • EC
  • InterPro Domains
    IPR006195 Aminoacyl-tRNA synthetase, class II
    IPR004364 Aminoacyl-tRNA synthetase, class II (D/K/N)
    IPR018150 Aminoacyl-tRNA synthetase, class II (D/K/N)-like
    IPR002313 Lysine-tRNA ligase, class II
    IPR018149 Lysyl-tRNA synthetase, class II, C-terminal
    IPR012340 Nucleic acid-binding, OB-fold
    IPR004365 OB-fold nucleic acid binding domain, AA-tRNA synthetase-type
Molecular
Reagents
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  • All nucleic 16
    cDNA 14
    Primer pair 2

    Microarray probesets 3
Other
Accession IDs
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MGD-MRK-34116, MGI:106422, MGI:1277111, MGI:2142434, MGI:2142665, MGI:2142669, MGI:2142671
References
more
  • Summaries
    All 41
    Developmental Gene Expression 3
    Gene Ontology 5
    Phenotypes 9
  • Earliest
    J:50869 Ko MSH, et al., Genome-wide mapping of unselected transcripts from extraembryonic tissue of 7.5-day mouse embryos reveals enrichment in the t-complex and under-representation on the X chromosome. Hum Mol Genet. 1998 Nov;7(12):1967-78
  • Latest
    J:153498 Diez-Roux G, et al., A high-resolution anatomical atlas of the transcriptome in the mouse embryo. PLoS Biol. 2011;9(1):e1000582

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
05/24/2016
MGI 6.04
The Jackson Laboratory