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Kars
Gene Detail
Symbol

Name
ID
Kars
lysyl-tRNA synthetase
MGI:1934754
Synonyms
D8Ertd698e, D8Wsu108e, LysRS, mKIAA0070
Feature Type
protein coding gene
Genetic Map
Chromosome 8
58.27 cM, cytoband D3
Detailed Genetic Map ± 1 cM


Mapping data(6)
Sequence Map
Chr8:111993440-112011323 bp, - strand
From Ensembl annotation of GRCm38

  17884 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:4053  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: KARS
Protein SuperFamily: lysine--tRNA ligase, class II
Gene Tree: Kars

Human
homologs
KARS, lysyl-tRNA synthetase
Orthology source: HomoloGene, HGNC

IDs:
NCBI Gene ID: 3735
neXtProt AC: NX_Q15046

Human Synonyms: CMTRIB, DFNB89, KARS1, KARS2, KRS

Human Chr (Location): 16q23.1; chr16:75627724-75647687 (-)  GRCh38.p2

Disease Associations: (2) Diseases Associated with Human KARS

Mutations,
alleles, and
phenotypes
All mutations/alleles(29) : Gene trapped(26) Targeted(3)
Incidental mutations (data from Mutagenetix , APF , CvDC )
Interactions
Kars interacts with 36 markers (Mir17, Mir20b, Mir22, ...)
Gene Ontology
(GO)
classifications
Expression
Literature Summary: (3 records)
Data Summary: Results (109)    Tissues (97)    Images (22)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 103
RT-PCR 6
cDNA source data(13)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase kars ; ZFIN kars    NEW 
Molecular
reagents
All nucleic(16) cDNA(14) Primer pair(2)
Microarray probesets(3)
Other database
links
Ensembl Gene Model ENSMUSG00000031948 (Evidence)
Entrez Gene 85305 (Evidence)
DFCI TC1571983, TC1729826
DoTS DT.55137285, DT.496447, DT.110876008, DT.101385429, DT.101385426, DT.101385419, DT.97362532
EC 6.1.1.6
Consensus CDS Project CCDS40481.1, CCDS52677.1
International Mouse Phenotyping Consortium Status Kars
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000031948 Ensembl Gene Model | MGI Sequence Detail 17884 C57BL/6J ±  kb
transcript ENSMUST00000093120 Ensembl | MGI Sequence Detail 2156 Not Applicable 
polypeptide ENSMUSP00000090808 Ensembl | MGI Sequence Detail 624 Not Applicable 

For the selected sequences
All sequences(64) RefSeq(8) UniProt(6)
Polymorphisms
SNPs within 2kb(256 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR006195 Aminoacyl-tRNA synthetase, class II
InterPro IPR004364 Aminoacyl-tRNA synthetase, class II (D/K/N)
InterPro IPR018150 Aminoacyl-tRNA synthetase, class II (D/K/N)-like
InterPro IPR002313 Lysine-tRNA ligase, class II
InterPro IPR018149 Lysyl-tRNA synthetase, class II, C-terminal
InterPro IPR012340 Nucleic acid-binding, OB-fold
InterPro IPR004365 Nucleic acid binding, OB-fold, tRNA/helicase-type
Protein Ontology PR:000009241 lysyl-tRNA synthetase
References
(Earliest) J:50869 Ko MSH, et al., Genome-wide mapping of unselected transcripts from extraembryonic tissue of 7.5-day mouse embryos reveals enrichment in the t-complex and under-representation on the X chromosome. Hum Mol Genet. 1998 Nov;7(12):1967-78
(Latest) J:153498 Diez-Roux G, et al., A high-resolution anatomical atlas of the transcriptome in the mouse embryo. PLoS Biol. 2011;9(1):e1000582
All references(42)
Other
accession IDs
MGD-MRK-34116, MGI:106422, MGI:1277111, MGI:2142434, MGI:2142665, MGI:2142669, MGI:2142671

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
05/20/2015
MGI 5.22
The Jackson Laboratory