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Rnf31 Gene Detail
Summary
  • Symbol
    Rnf31
  • Name
    ring finger protein 31
  • Synonyms
    HOIP, Paul
  • Feature Type
    protein coding gene
  • IDs
    MGI:1934704
    NCBI Gene: 268749
  • Gene Overview
    MyGene.info: RNF31
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr14:55591708-55603693 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      11986 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 14, 28.19 cM
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    RNF31, ring finger protein 31
  • Vertebrate Orthologs
    8
  • Human Ortholog
    RNF31, ring finger protein 31
    Orthology source: HomoloGene, HGNC
  • Synonyms
    HOIP, Paul, ZIBRA
  • Links
    NCBI Gene ID: 55072
    neXtProt AC: NX_Q96EP0
    UniProt: Q96EP0

  • Chr Location
    14q12; chr14:24146875-24160661 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    12 phenotypes from 2 alleles in 2 genetic backgrounds
    13 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit complete embryonic lethality. Mice homozygous for a conditional allele activated in B cells exhibit severely impaired B1 B cell development and impaired antibody responses to both T cell-dependent and T cell-independent type 2 antigens.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic OTTMUSG00000029026 VEGA Gene Model | MGI Sequence Detail 11986 C57BL/6J ±  kb
    transcript OTTMUST00000072008 VEGA | MGI Sequence Detail 3485 Not Applicable  
    polypeptide OTTMUSP00000036980 VEGA | MGI Sequence Detail 1066 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      27 from dbSNP Build 142
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 42
      cDNA 41
      Primer pair 1

      Microarray probesets 1
    Other
    Accession IDs
    less
    MGI:2145719, MGI:2448574
    References
    more
    • Summaries
      All 48
      Developmental Gene Expression 4
      Gene Ontology 10
      Phenotypes 13
    • Earliest
      J:68979 Yawata M, et al., Nucleotide sequence analysis of the approximately 35-kb segment containing interferon-gamma-inducible mouse proteasome activator genes. Immunogenetics. 2001 Mar;53(2):119-29
    • Latest
      J:256084 Shimizu Y, et al., The Linear ubiquitin chain assembly complex acts as a liver tumor suppressor and inhibits hepatocyte apoptosis and hepatitis. Hepatology. 2017 Jun;65(6):1963-1978

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
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    last database update
    05/08/2018
    MGI 6.12
    The Jackson Laboratory