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Tnfrsf25 Gene Detail
Summary
  • Symbol
    Tnfrsf25
  • Name
    tumor necrosis factor receptor superfamily, member 25
  • Synonyms
    APO-3, DDR3, DR3, LARD, Tnfrsf12, TR3, TRAMP, Wsl, WSL-1, WSL-LR
  • Feature Type
    protein coding gene
  • IDs
    MGI:1934667
    NCBI Gene: 85030
  • Gene Overview
    MyGene.info: TNFRSF25
  • Alliance
  • Transcription Start Sites
    6 TSS
Location &
Maps
more
  • Sequence Map
    Chr4:152115934-152120119 bp, + strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 4, 82.89 cM, cytoband E1
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    25 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1934667
protein coding gene Chr4:152115528-152120119 (.)
129S1/SvImJ MGP_129S1SvImJ_G0029172
protein coding gene Chr4:156215622-156219815 (+)
A/J MGP_AJ_G0029137
protein coding gene Chr4:149656731-149660916 (+)
AKR/J MGP_AKRJ_G0029085
protein coding gene Chr4:153731453-153735638 (+)
BALB/cJ MGP_BALBcJ_G0029153
protein coding gene Chr4:150138561-150142746 (+)
C3H/HeJ MGP_C3HHeJ_G0028874
protein coding gene Chr4:154300507-154304692 (+)
C57BL/6NJ MGP_C57BL6NJ_G0029602
protein coding gene Chr4:161810368-161814553 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0026848
protein coding gene Chr4:142018861-142023053 (+)
CAST/EiJ MGP_CASTEiJ_G0028287
protein coding gene Chr4:151643330-151647532 (+)
CBA/J MGP_CBAJ_G0028836
protein coding gene Chr4:166625495-166629680 (+)
DBA/2J MGP_DBA2J_G0028985
protein coding gene Chr4:149717963-149722148 (+)
FVB/NJ MGP_FVBNJ_G0028949
protein coding gene Chr4:148872863-148877048 (+)
LP/J MGP_LPJ_G0029075
protein coding gene Chr4:156131508-156135693 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0028976
protein coding gene Chr4:169666218-169670403 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0029634
protein coding gene Chr4:154276625-154280810 (+)
PWK/PhJ MGP_PWKPhJ_G0028007
protein coding gene Chr4:145789248-145793440 (+)
SPRET/EiJ MGP_SPRETEiJ_G0027841
protein coding gene Chr4:148557700-148561862 (+)
WSB/EiJ MGP_WSBEiJ_G0028367
protein coding gene Chr4:154441634-154445840 (+)



Homology
more
  • Human Ortholog
    TNFRSF25, TNF receptor superfamily member 25
  • Vertebrate Orthologs
    8
  • Human Ortholog
    TNFRSF25, TNF receptor superfamily member 25
    Orthology source: HGNC, HomoloGene
  • Synonyms
    APO-3, DDR3, DR3, GEF720, LARD, PLEKHG5, TNFRSF12, TR3, TRAMP, WSL-1, WSL-LR
  • Links
    NCBI Gene ID: 8718
    neXtProt AC: NX_Q93038
    UniProt: Q93038

  • Chr Location
    1p36.31; chr1:6461151-6466195 (-)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    4 phenotypes from 1 allele in 1 genetic background
    5 phenotypes from multigenic genotypes
    18 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygous mutant mice show no developmental defects or impairments of early thymocyte development. Negative selection and anti-CD3-induced apoptosis, however, are significantly impaired.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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  • cDNA Data
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000024793 Ensembl Gene Model | MGI Sequence Detail 4186 C57BL/6J ±  kb
transcript ENSMUST00000025706 Ensembl | MGI Sequence Detail 1661 Not Applicable  
polypeptide ENSMUSP00000025706 Ensembl | MGI Sequence Detail 411 Not Applicable  
For the selected sequence
Protein
Information
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  • UniProt
    3 Sequences
  • InterPro Domains
    IPR000488 Death domain
    IPR011029 Death-like domain superfamily
    IPR001368 TNFR/NGFR cysteine-rich region
    IPR034050 Tumor necrosis factor receptor 25, N-terminal
    IPR022329 Tumour necrosis factor receptor 25
Molecular
Reagents
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  • All nucleic 8
    Genomic 1
    cDNA 7

    Microarray probesets 2
References
more
  • Summaries
    All 45
    Gene Ontology 1
    Phenotypes 18
  • Earliest
    J:68679 Wang EC, et al., Genomic structure, expression, and chromosome mapping of the mouse homologue for the WSL-1 (DR3, Apo3, TRAMP, LARD, TR3, TNFRSF12) gene. Immunogenetics. 2001 Feb;53(1):59-63
  • Latest
    J:255158 Collins FL, et al., CCL3 and MMP-9 are induced by TL1A during death receptor 3 (TNFRSF25)-dependent osteoclast function and systemic bone loss. Bone. 2017 Apr;97:94-104

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
12/11/2018
MGI 6.13
The Jackson Laboratory