Tnfrsf25 MGI Mouse Gene Detail - MGI:1934667 - tumor necrosis factor receptor superfamily, member 25

Symbol

Tnfrsf25
Name

tumor necrosis factor receptor superfamily, member 25
Synonyms

APO-3, DDR3, DR3, LARD, Tnfrsf12, TR3, TRAMP, Wsl, WSL-1, WSL-LR

Feature Type

protein coding gene
IDs

MGI:1934667
NCBI Gene: 85030
Alliance

gene page
Transcription Start Sites

6 TSS

Sequence Map

Chr4:152200391-152204576 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 4, 82.89 cM, cytoband E1
Mapping Data

1 experiment

SNPs within 2kb

25 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1934667	protein coding gene	Chr4:152199985-152204576 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0029172	protein coding gene	Chr4:156215622-156219815 (+)
A/J	MGP_AJ_G0029137	protein coding gene	Chr4:149656731-149660916 (+)
AKR/J	MGP_AKRJ_G0029085	protein coding gene	Chr4:153731453-153735638 (+)
BALB/cJ	MGP_BALBcJ_G0029153	protein coding gene	Chr4:150138561-150142746 (+)
C3H/HeJ	MGP_C3HHeJ_G0028874	protein coding gene	Chr4:154300507-154304692 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0029602	protein coding gene	Chr4:161810368-161814553 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0026848	protein coding gene	Chr4:142018861-142023053 (+)
CAST/EiJ	MGP_CASTEiJ_G0028287	protein coding gene	Chr4:151643330-151647532 (+)
CBA/J	MGP_CBAJ_G0028836	protein coding gene	Chr4:166625495-166629680 (+)
DBA/2J	MGP_DBA2J_G0028985	protein coding gene	Chr4:149717963-149722148 (+)
FVB/NJ	MGP_FVBNJ_G0028949	protein coding gene	Chr4:148872863-148877048 (+)
LP/J	MGP_LPJ_G0029075	protein coding gene	Chr4:156131508-156135693 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0028976	protein coding gene	Chr4:169666218-169670403 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0029634	protein coding gene	Chr4:154276625-154280810 (+)
PWK/PhJ	MGP_PWKPhJ_G0028007	protein coding gene	Chr4:145789248-145793440 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0027841	protein coding gene	Chr4:148557700-148561862 (+)
WSB/EiJ	MGP_WSBEiJ_G0028367	protein coding gene	Chr4:154441634-154445840 (+)

Human Ortholog

TNFRSF25, TNF receptor superfamily member 25

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

TNFRSF25, TNF receptor superfamily member 25
Synonyms

APO-3, DDR3, DR3, GEF720, LARD, PLEKHG5, TNFRSF12, TR3, TRAMP, WSL-1, WSL-LR
Links

HGNC:11910

NCBI Gene ID: 8718

neXtProt AC: NX_Q93038

UniProt: Q93038
Chr Location

1p36.31; chr1:6460786-6466175 (-) GRCh38

MGI Vertebrate Homology

Tnfrsf25 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: TNFRSF25
Gene Tree

Tnfrsf25

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Phenotype Summary

4 phenotypes from 1 allele in 1 genetic background
5 phenotypes from multigenic genotypes
33 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

12
Endonuclease-mediated

3
Gene trapped

1
Targeted

8
Genomic Mutations

3 involving Tnfrsf25
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

24 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Homozygous mutant mice show no developmental defects or impairments of early thymocyte development. Negative selection and anti-CD3-induced apoptosis, however, are significantly impaired.

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All GO Annotations

2
GO References

2

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

706
cDNA Data

7

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas

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All Sequences

45
RefSeq

13
UniProt

3
CCDS

CCDS38983.1, CCDS71527.1

Ensembl

ENSMUSG00000024793 (Evidence)
NCBI Gene

85030

			Length	Strain/Species	Flank
genomic	ENSMUSG00000024793	Ensembl Gene Model \| MGI Sequence Detail	4186	C57BL/6J	± kb
transcript	ENSMUST00000025706	Ensembl \| MGI Sequence Detail	1661	Not Applicable
polypeptide	ENSMUSP00000025706	Ensembl \| MGI Sequence Detail	411	Not Applicable

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UniProt

3 Sequences
PDB

5ZNY, 5ZNZ
InterPro Domains

IPR000488 Death domain

IPR011029 Death-like domain superfamily

IPR001368 TNFR/NGFR cysteine-rich region

IPR034050 Tumor necrosis factor receptor 25, N-terminal

IPR022329 Tumour necrosis factor receptor 25

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All nucleic 8

Genomic 1

cDNA 7

Microarray probesets 2

Summaries

All 67

Gene Ontology 2

Phenotypes 33
Earliest

J:68679 Wang EC, et al., Genomic structure, expression, and chromosome mapping of the mouse homologue for the WSL-1 (DR3, Apo3, TRAMP, LARD, TR3, TNFRSF12) gene. Immunogenetics. 2001 Feb;53(1):59-63
Latest

J:344363 Zhang D, et al., Identification of a novel role for TL1A/DR3 deficiency in acute respiratory distress syndrome that exacerbates alveolar epithelial disruption. Respir Res. 2023 Jul 11;24(1):182

TSS for Tnfrsf25:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr40501	Chr4:152200474-152200485 (+)	89 bp
Tssr40502	Chr4:152200493-152200537 (+)	124 bp
Tssr40503	Chr4:152200734-152200741 (+)	347 bp
Tssr40504	Chr4:152200769-152200794 (+)	391 bp
Tssr40505	Chr4:152200849-152200859 (+)	463 bp
Tssr40506	Chr4:152200891-152200900 (+)	505 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 04/16/2024 MGI 6.23