Lias
Gene Detail

Symbol Name ID

Lias lipoic acid synthetase MGI:1934604

Synonyms

2900022L22Rik, 4933425M12Rik, 7a5ex, MGC7254, mLip1

Feature Type

protein coding gene

Genetic Map

Chromosome 5

33.66 cM, cytoband C3.3
Detailed Genetic Map ± 1 cM


Mapping data(5)

Sequence Map

Chr5:65391497-65410693 bp, + strand From VEGA annotation of GRCm38   19197 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Mammalian homology

human; rat; cattle; chimpanzee; dog, domestic    (Mammalian Orthology)
Comparative Map (Mouse/Human Lias ± 2 cM)

Protein SuperFamily: lipoyl synthase
Gene Tree: Lias

Human ortholog

LIAS lipoic acid synthetase NCBI Gene ID 11019
Human Synonyms: LAS, LIP1, LS, PDHLD
Human Chr4:39460665-39479273 bp, + strand Reference GRCh37.p2 Primary Assembly
Human Diseases Associated with Human LIAS (1)

Alleles and phenotypes

All alleles(21) : Targeted(3) Gene trapped(17) Chemically induced(1)
 

Mice homozygous for a gene trap allele die before weaning. Embryos homozygous for a null allele become growth arrested and die at E7.5-E9.5. Embryos homozygous for an ENU allele survive to E12.5 showing a growth delay, an open neural tube, microcephaly, dilated hearts and lack of dorsal forebrain.

 

Gene Ontology (GO) classifications

All GO classifications: (14 annotations)

Process	inflammatory response, lipoate biosynthetic process, ...
Component	mitochondrion
Function	4 iron, 4 sulfur cluster binding, catalytic activity, ...

This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase

Expression

Literature Summary: (2 records)
Data Summary: Results (94)    Tissues (94)    Images (2)
Theiler Stages: 22

Assay Type	Results
RNA in situ	94

cDNA source data(8)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(11) cDNA(11)
Microarray probesets(5)

Other database links

VEGA Gene Model	OTTMUSG00000028341 (Evidence)
Ensembl Gene Model	ENSMUSG00000029199 (Evidence)
Entrez Gene	79464 (Evidence)
DFCI	TC1576426, TC1603455
DoTS	DT.101734615, DT.94381873
NIA Mouse Gene Index	U005627
EC	2.8.1.8
Consensus CDS Project	CCDS19307.1
International Mouse Knockout Project Status	Lias

Sequences

Length	Strain/Species
genomic	OTTMUSG00000028341	VEGA Gene Model | MGI Sequence Detail	19197	C57BL/6J
transcript	OTTMUST00000070247	VEGA | MGI Sequence Detail	3154	Not Applicable
polypeptide	OTTMUSP00000035767	VEGA | MGI Sequence Detail	373	Not Applicable

All sequences(36) RefSeq(2) UniProt(3)

Polymorphisms

SNPs(115 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR013785	Aldolase-type TIM barrel
InterPro	IPR006638	Elongator protein 3/MiaB/NifB
InterPro	IPR003698	Lipoyl synthase
InterPro	IPR007197	Radical SAM
Protein Ontology	PR:000009798	lipoyl synthase, mitochondrial

References

(Earliest) J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
(Latest) J:153498 Diez-Roux G, et al., A high-resolution anatomical atlas of the transcriptome in the mouse embryo. PLoS Biol. 2011;9(1):e1000582
All references(43)

Other accession IDs

MGI:1918344, MGI:1924081, MGI:2141287, MGI:3578164