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Lias
Gene Detail
Symbol

Name
ID
Lias
lipoic acid synthetase
MGI:1934604
Synonyms
2900022L22Rik, 4933425M12Rik, 7a5ex, MGC7254, mLip1
Feature Type
protein coding gene
Genetic Map
Chromosome 5
33.66 cM, cytoband C3.3
Detailed Genetic Map ± 1 cM


Mapping data(5)
Sequence Map
Chr5:65391497-65410693 bp, + strand
From VEGA annotation of GRCm38

  19197 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:4997  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 2 western clawed frog; 1 zebrafish

HCOP human homology predictions: LIAS
Protein SuperFamily: lipoyl synthase
Gene Tree: Lias

Human
homologs
LIAS, lipoic acid synthetase
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 11019
neXtProt AC: NX_O43766

Human Synonyms: HUSSY-01, LAS, LIP1, LS, PDHLD

Human Chr (Location): 4p14; chr4:39459024-39477653 (+)  GRCh38.p2

Disease Associations: (1) Diseases Associated with Human LIAS

Mutations,
alleles, and
phenotypes
All mutations/alleles(22) : Chemically induced (ENU)(1) Gene trapped(17) Radiation induced(1) Targeted(3)
Genomic Mutations involving Lias (1)
Incidental mutations (data from APF )
 
Mice homozygous for a gene trap allele die before weaning. Embryos homozygous for a null allele become growth arrested and die at E7.5-E9.5. Embryos homozygous for an ENU allele survive to E12.5 showing a growth delay, an open neural tube, microcephaly, dilated hearts and lack of dorsal forebrain.
 
Phenotype Images(4)
Interactions
Lias interacts with 198 markers (Mir1a-1, Mir1a-2, Mir7-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (15 annotations)
Process inflammatory response, lipoate biosynthetic process, ...
Component mitochondrion
Function 4 iron, 4 sulfur cluster binding, catalytic activity, ...
This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase
Expression
Literature Summary: (2 records)
Data Summary: Results (94)    Tissues (94)    Images (2)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 94
cDNA source data(63)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase lias    NEW 
Molecular
reagents
All nucleic(66) cDNA(66)
Microarray probesets(5)
Other database
links
VEGA Gene Model OTTMUSG00000028341 (Evidence)
Ensembl Gene Model ENSMUSG00000029199 (Evidence)
Entrez Gene 79464 (Evidence)
UniGene 195776
DFCI TC1576426, TC1603455
DoTS DT.94381873, DT.101734615
NIA Mouse Gene Index U005627
EC 2.8.1.8
Consensus CDS Project CCDS19307.1
International Mouse Phenotyping Consortium Status Lias
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000028341 VEGA Gene Model | MGI Sequence Detail 19197 C57BL/6J ±  kb
transcript OTTMUST00000070247 VEGA | MGI Sequence Detail 3154 Not Applicable 
polypeptide OTTMUSP00000035767 VEGA | MGI Sequence Detail 373 Not Applicable 

For the selected sequences
All sequences(40) RefSeq(6) UniProt(3)
Polymorphisms
SNPs within 2kb(143 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR013785 Aldolase-type TIM barrel
InterPro IPR006638 Elongator protein 3/MiaB/NifB
InterPro IPR003698 Lipoyl synthase
InterPro IPR007197 Radical SAM
Protein Ontology PR:000009798 lipoyl synthase, mitochondrial
References
(Earliest) J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
(Latest) J:153498 Diez-Roux G, et al., A high-resolution anatomical atlas of the transcriptome in the mouse embryo. PLoS Biol. 2011;9(1):e1000582
All references(43)
Other
accession IDs
MGI:1918344, MGI:1924081, MGI:2141287, MGI:3578164

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/21/2015
MGI 5.22
The Jackson Laboratory