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Cxcr6
Gene Detail
 Symbol
Name
ID
Cxcr6
chemokine (C-X-C motif) receptor 6
MGI:1934582
Synonyms BONZO, STRL33
Feature Type protein coding gene
Genetic Map
Chromosome 9
74.57 cM, cytoband F
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr9:123806477-123811754 bp, + strand
From NCBI annotation of GRCm38

  5278 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:38197  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog

Protein SuperFamily: chemokine receptor
Gene Tree: Cxcr6

Human
homologs
Human Homolog CXCR6, chemokine (C-X-C motif) receptor 6
NCBI Gene ID 10663
neXtProt AC  NX_O00574
Human Synonyms  BONZO, CD186, STRL33, TYMSTR
Human Chr (Location)  3p21; chr3:45943481-45948353 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(4) : Targeted(4)
Incidental mutations (data from Mutagenetix , APF )
 
A small percentage of mice that are heterozygous or homozygous for a knock-out allele develop medulloblastomas in the cerebellum after 12 months of age.
 
Interactions
Cxcr6 interacts with 160 markers (Mir15a, Mir15b, Mir16-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (15 annotations)
Process chemokine-mediated signaling pathway, chemotaxis, ...
Component integral component of membrane, membrane, ...
Function chemokine receptor activity, coreceptor activity, ...
External Resources: FuncBase
Expression
Literature Summary: (4 records)
Data Summary: Results (45)    Tissues (43)    Images (9)
Theiler Stages: 19, 23, 26, 28
Assay TypeResults
RNA in situ 41
RT-PCR 4
cDNA source data(37)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(38) cDNA(37) Primer pair(1)
Microarray probesets(3)
Other database
links
Ensembl Gene ModelENSMUSG00000048521 (Evidence)
Entrez Gene80901 (Evidence)
UniGene124289
DFCITC1580674
DoTSDT.101230881, DT.110608829, DT.55183531, DT.94262790
NIA Mouse Gene IndexU011201
Consensus CDS ProjectCCDS23664.1
International Mouse Knockout Project StatusCxcr6
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 80901 NCBI Gene Model | MGI Sequence Detail 5278 C57BL/6J ±  kb
transcript NM_030712 RefSeq | MGI Sequence Detail 1893 C57BL/6 
polypeptide Q9EQ16 UniProt | EBI | MGI Sequence Detail 351 Not Applicable 

For the selected sequences
All sequences(24) RefSeq(4) UniProt(1)
Polymorphisms SNPs within 2kb(159 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR000355 Chemokine receptor family
InterPro IPR002235 CXC chemokine receptor 6
InterPro IPR017452 GPCR, rhodopsin-like, 7TM
InterPro IPR000276 G protein-coupled receptor, rhodopsin-like
Protein Ontology PR:000001210 C-X-C chemokine receptor type 6
Graphical View of Protein Domain Structure
References (Earliest) J:65117 Matloubian M, et al., A transmembrane CXC chemokine is a ligand for HIV-coreceptor Bonzo. Nat Immunol. 2000 Oct;1(4):298-304
(Latest) J:208876 Zaid A, et al., Persistence of skin-resident memory T cells within an epidermal niche. Proc Natl Acad Sci U S A. 2014 Apr 8;111(14):5307-12
All references(48)
Other
accession IDs
MGI:2143371

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/12/2014
MGI 5.19
The Jackson Laboratory