Cxcr6
Gene Detail

Symbol Name ID

Cxcr6 chemokine (C-X-C motif) receptor 6 MGI:1934582

Synonyms

BONZO, STRL33

Feature Type

protein coding gene

Genetic Map

Chromosome 9

74.57 cM, cytoband F
Detailed Genetic Map ± 1 cM


Mapping data(3)

Sequence Map

Chr9:123806477-123811754 bp, + strand From NCBI annotation of GRCm38   5278 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:38197  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog

Protein SuperFamily: chemokine receptor
Gene Tree: Cxcr6

Human homologs

Human Homolog		CXCR6, chemokine (C-X-C motif) receptor 6
NCBI Gene ID		10663
neXtProt AC		NX_O00574
Human Synonyms		BONZO, CD186, STRL33, TYMSTR
Human Chr (Location)		3p21; chr3:45984973-45989845 (+)  GRCh37.p10

Alleles and phenotypes

All alleles(4) : Targeted(4)
 

A small percentage of mice that are heterozygous or homozygous for a knock-out allele develop medulloblastomas in the cerebellum after 12 months of age.

 

Gene Ontology (GO) classifications

All GO classifications: (19 annotations)

Process	chemokine-mediated signaling pathway, chemotaxis, ...
Component	integral to membrane, membrane, ...
Function	chemokine receptor activity, chloroplast protein-transporting ATPase activity, ...

External Resources: FuncBase

Expression

Literature Summary: (4 records)
Data Summary: Results (45)    Tissues (43)    Images (9)
Theiler Stages: 19, 23, 26, 28

Assay Type	Results
RNA in situ	41
RT-PCR	4

cDNA source data(37)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(38) cDNA(37) Primer pair(1)
Microarray probesets(3)

Other database links

Ensembl Gene Model	ENSMUSG00000048521 (Evidence)
Entrez Gene	80901 (Evidence)
UniGene	124289
DFCI	TC1580674
DoTS	DT.101230881, DT.110608829, DT.55183531, DT.94262790
NIA Mouse Gene Index	U011201
Consensus CDS Project	CCDS23664.1
International Mouse Knockout Project Status	Cxcr6

Sequences

Length	Strain/Species
genomic	80901	NCBI Gene Model | MGI Sequence Detail	5278	C57BL/6J
transcript	NM_030712	RefSeq | MGI Sequence Detail	1893	C57BL/6
polypeptide	Q9EQ16	UniProt | EBI | MGI Sequence Detail	351	Not Applicable

All sequences(21) RefSeq(2) UniProt(1)

Polymorphisms

SNPs(25 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR000355	Chemokine receptor
InterPro	IPR002235	CXC chemokine receptor, type 6
InterPro	IPR000276	GPCR, rhodopsin-like
InterPro	IPR017452	GPCR, rhodopsin-like, 7TM
Protein Ontology	PR:000001210	C-X-C chemokine receptor type 6

Graphical View of Protein Domain Structure

References

(Earliest) J:65117 Matloubian M, et al., A transmembrane CXC chemokine is a ligand for HIV-coreceptor Bonzo. Nat Immunol. 2000 Oct;1(4):298-304
(Latest) J:194479 Kastenmuller W, et al., Peripheral Prepositioning and Local CXCL9 Chemokine-Mediated Guidance Orchestrate Rapid Memory CD8(+) T Cell Responses in the Lymph Node. Immunity. 2013 Mar 21;38(3):502-13
All references(44)

Other accession IDs

MGI:2143371