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Cxcr6
Gene Detail
Symbol

Name
ID
Cxcr6
chemokine (C-X-C motif) receptor 6
MGI:1934582
Synonyms
BONZO, STRL33
Feature Type
protein coding gene
Genetic Map
Chromosome 9
74.57 cM, cytoband F
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr9:123806477-123811754 bp, + strand
From Ensembl annotation of GRCm38

  5278 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:38197  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 western clawed frog

HCOP human homology predictions: CXCR6
Protein SuperFamily: chemokine receptor
Gene Tree: Cxcr6

Human
homologs
CXCR6, chemokine (C-X-C motif) receptor 6
Orthology source: HomoloGene, HGNC

IDs:
NCBI Gene ID: 10663
neXtProt AC: NX_O00574

Human Synonyms: BONZO, CD186, STRL33, TYMSTR

Human Chr (Location): 3p21; chr3:45940399-45948354 (+)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(4) : Targeted(4)
Incidental mutations (data from Mutagenetix , APF )
 
A small percentage of mice that are heterozygous or homozygous for a knock-out allele develop medulloblastomas in the cerebellum after 12 months of age.
 
Interactions
Cxcr6 interacts with 159 markers (Mir15a, Mir15b, Mir16-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (16 annotations)
Process chemokine-mediated signaling pathway, chemotaxis, ...
Component integral component of membrane, membrane, ...
Function chemokine receptor activity, coreceptor activity, ...
External Resources: FuncBase
Expression
Literature Summary: (4 records)
Data Summary: Results (45)    Tissues (44)    Images (9)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 41
RT-PCR 4
cDNA source data(37)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase cxcr6    NEW 
Molecular
reagents
All nucleic(38) cDNA(37) Primer pair(1)
Microarray probesets(3)
Other database
links
Ensembl Gene Model ENSMUSG00000048521 (Evidence)
Entrez Gene 80901 (Evidence)
UniGene 124289
DFCI TC1580674
DoTS DT.110608829, DT.101230881, DT.94262790, DT.55183531
NIA Mouse Gene Index U011201
Consensus CDS Project CCDS23664.1
International Mouse Phenotyping Consortium Status Cxcr6
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000048521 Ensembl Gene Model | MGI Sequence Detail 5278 C57BL/6J ±  kb
transcript ENSMUST00000049810 Ensembl | MGI Sequence Detail 1893 Not Applicable 
polypeptide ENSMUSP00000060776 Ensembl | MGI Sequence Detail 351 Not Applicable 

For the selected sequences
All sequences(24) RefSeq(4) UniProt(1)
Polymorphisms
SNPs within 2kb(159 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR000355 Chemokine receptor family
InterPro IPR002235 CXC chemokine receptor 6
InterPro IPR017452 GPCR, rhodopsin-like, 7TM
InterPro IPR000276 G protein-coupled receptor, rhodopsin-like
Protein Ontology PR:000001210 C-X-C chemokine receptor type 6
References
(Earliest) J:65117 Matloubian M, et al., A transmembrane CXC chemokine is a ligand for HIV-coreceptor Bonzo. Nat Immunol. 2000 Oct;1(4):298-304
(Latest) J:216200 Tong PL, et al., The skin immune atlas: three-dimensional analysis of cutaneous leukocyte subsets by multiphoton microscopy. J Invest Dermatol. 2015 Jan;135(1):84-93
All references(52)
Other
accession IDs
MGI:2143371

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
05/20/2015
MGI 5.22
The Jackson Laboratory