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Kcnn1 Gene Detail
Summary
  • Symbol
    Kcnn1
  • Name
    potassium intermediate/small conductance calcium-activated channel, subfamily N, member 1
  • Synonyms
    SK1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1933993
    NCBI Gene: 84036
  • Gene Overview
    MyGene.info: KCNN1
  • Alliance
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr8:70842049-70863258 bp, - strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 8, 34.27 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    147 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1933993
protein coding gene Chr8:70842049-70863258 (-)
129S1/SvImJ MGP_129S1SvImJ_G0033730
protein coding gene Chr8:71152441-71169093 (-)
A/J MGP_AJ_G0033713
protein coding gene Chr8:68247135-68262201 (-)
AKR/J MGP_AKRJ_G0033638
protein coding gene Chr8:70207857-70222779 (-)
BALB/cJ MGP_BALBcJ_G0033709
protein coding gene Chr8:68482069-68496870 (-)
C3H/HeJ MGP_C3HHeJ_G0033419
protein coding gene Chr8:70850506-70866810 (-)
C57BL/6NJ MGP_C57BL6NJ_G0034226
protein coding gene Chr8:73826252-73843627 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0031170
protein coding gene Chr8:63064939-63080496 (-)
CAST/EiJ MGP_CASTEiJ_G0032744
protein coding gene Chr8:70325577-70344021 (-)
CBA/J MGP_CBAJ_G0033397
protein coding gene Chr8:76489512-76506281 (-)
DBA/2J MGP_DBA2J_G0033551
protein coding gene Chr8:67967245-67982210 (-)
FVB/NJ MGP_FVBNJ_G0033492
protein coding gene Chr8:67104824-67120834 (-)
LP/J MGP_LPJ_G0033638
protein coding gene Chr8:71165399-71188678 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0033535
protein coding gene Chr8:79121378-79138566 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0034244
protein coding gene Chr8:70387380-70402416 (-)
PWK/PhJ MGP_PWKPhJ_G0032452
protein coding gene Chr8:67263806-67285976 (-)
SPRET/EiJ MGP_SPRETEiJ_G0032288
protein coding gene Chr8:69363274-69377328 (-)
WSB/EiJ MGP_WSBEiJ_G0032859
protein coding gene Chr8:70750834-70773901 (-)



Homology
more
  • Human Ortholog
    KCNN1, potassium calcium-activated channel subfamily N member 1
  • Vertebrate Orthologs
    7
  • Human Ortholog
    KCNN1, potassium calcium-activated channel subfamily N member 1
    Orthology source: HomoloGene, HGNC
  • Synonyms
    hSK1, KCa2.1, SK1, SKCA1
  • Links
    NCBI Gene ID: 3780
    neXtProt AC: NX_Q92952
    UniProt: Q92952

  • Chr Location
    19p13.11; chr19:17951302-17999121 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    9 phenotype references
Homozygous null mice display normal hippocampal morphology and afterhyperpolarization currents.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 84036 NCBI Gene Model | MGI Sequence Detail 21210 C57BL/6J ±  kb
transcript NM_001363407 RefSeq | MGI Sequence Detail 3270 C57BL/6  
polypeptide Q9EQR3 UniProt | EBI | MGI Sequence Detail 537 Not Applicable  
For the selected sequence
Protein
Information
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  • UniProt
    8 Sequences
  • InterPro Domains
    IPR004178 Calmodulin-binding domain
    IPR015449 Potassium channel, calcium-activated, SK
    IPR013099 Potassium channel domain
    IPR036122 SK, calmodulin-binding domain superfamily
Molecular
Reagents
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  • All nucleic 21
    cDNA 20
    Primer pair 1

    Microarray probesets 4
Other
Accession IDs
less
MGI:2142641
References
more
  • Summaries
    All 39
    Developmental Gene Expression 2
    Gene Ontology 7
    Phenotypes 9
  • Earliest
    J:68341 Shmukler BE, et al., Structure and complex transcription pattern of the mouse SK1 K(Ca) channel gene, KCNN1. Biochim Biophys Acta. 2001 Mar 19;1518(1-2):36-46
  • Latest
    J:232973 Hirst CS, et al., Ion channel expression in the developing enteric nervous system. PLoS One. 2015;10(3):e0123436

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/06/2018
MGI 6.13
The Jackson Laboratory