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Rbfox2 Gene Detail
Summary
  • Symbol
    Rbfox2
  • Name
    RNA binding protein, fox-1 homolog (C. elegans) 2
  • Synonyms
    2810460A15Rik, Fbm2, Fxh, Rbm9
  • Feature Type
    protein coding gene
  • IDs
    MGI:1933973
    NCBI Gene: 93686
  • Gene Overview
    MyGene.info: RBFOX2
Location & Maps
more
  • Sequence Map
    Chr15:77078990-77307053 bp, - strand
  • From NCBI annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      228064 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 15, 36.40 cM, cytoband E1
  • Mapping Data
    3 experiments
Homology
more
  • Human Ortholog
    RBFOX2, RNA binding protein, fox-1 homolog 2
  • Vertebrate Orthologs
    7
  • Human Ortholog
    RBFOX2, RNA binding protein, fox-1 homolog 2
    Orthology source: HomoloGene
  • Synonyms
    dJ106I20.3, Fox-2, FOX2, fxh, HNRBP2, HRNBP2, RBM9, RTA
  • Links
    NCBI Gene ID: 23543
    neXtProt AC: NX_O43251

  • Chr Location
    22q13.1; chr22:35738736-36028892 (-)  GRCh38.p2

Human Diseases
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  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    15 phenotypes from 1 allele in 1 genetic background
    10 phenotypes from multigenic genotypes
    33 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    123
  • Chemically induced (other)
    3
  • Gene trapped
    113
  • Radiation induced
    2
  • Targeted
    5
  • Genomic Mutations
    5 involving Rbfox2
  • Incidental Mutations
Mice homozygous for a conditional allele activated in the brain exhibit normal spontaneous and kainic acid-induced seizures.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 93686 NCBI Gene Model | MGI Sequence Detail 228064 C57BL/6J ±  kb
transcript NM_053104 RefSeq | MGI Sequence Detail 7032 C57BL/6  
polypeptide Q8BP71 UniProt | EBI | MGI Sequence Detail 449 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    642 from dbSNP Build 142
Protein
Information
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  • UniProt
    1 Sequence
  • Protein Ontology
    PR:000013810 RNA binding protein fox-1 homolog 2
  • InterPro Domains
    IPR025670 Fox-1 C-terminal domain
    IPR012677 Nucleotide-binding alpha-beta plait domain
    IPR017325 RNA binding protein Fox-1
    IPR000504 RNA recognition motif domain
Molecular
Reagents
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  • All nucleic 20
    cDNA 16
    Primer pair 4

    Microarray probesets 9
Other
Accession IDs
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MGI:1920085, MGI:2145891, MGI:2145951, MGI:894685
References
more
  • Summaries
    All 54
    Developmental Gene Expression 10
    Diseases 1
    Gene Ontology 12
    Phenotypes 33
  • Earliest
    J:41036 Kai N, et al., Molecular cloning of Fyn-associated molecules in the mouse central nervous system. J Neurosci Res. 1997 Jun 1;48(5):407-24
  • Latest
    J:224530 Dietrich JE, et al., Venus trap in the mouse embryo reveals distinct molecular dynamics underlying specification of first embryonic lineages. EMBO Rep. 2015 Aug;16(8):1005-21

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
06/22/2016
MGI 6.04
The Jackson Laboratory