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Rbfox2 Gene Detail
Summary
  • Symbol
    Rbfox2
  • Name
    RNA binding protein, fox-1 homolog (C. elegans) 2
  • Synonyms
    2810460A15Rik, Fbm2, Fxh, Rbm9
  • Feature Type
    protein coding gene
  • IDs
    MGI:1933973
    NCBI Gene: 93686
  • Gene Overview
    MyGene.info: RBFOX2
  • Alliance
  • Transcription Start Sites
    14 TSS
Location &
Maps
more
  • Sequence Map
    Chr15:77078990-77307004 bp, - strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 15, 36.40 cM, cytoband E1
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    642 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1933973
protein coding gene Chr15:77078990-77307088 (-)
129S1/SvImJ MGP_129S1SvImJ_G0022021
protein coding gene Chr15:77224338-77469411 (-)
A/J MGP_AJ_G0021979
protein coding gene Chr15:74363392-74592594 (-)
AKR/J MGP_AKRJ_G0021962
protein coding gene Chr15:76399769-76632114 (-)
BALB/cJ MGP_BALBcJ_G0021988
protein coding gene Chr15:74387427-74617390 (-)
C3H/HeJ MGP_C3HHeJ_G0021760
protein coding gene Chr15:76437946-76669878 (-)
C57BL/6NJ MGP_C57BL6NJ_G0022428
protein coding gene Chr15:80088764-80337004 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0019957
protein coding gene Chr15:71010448-71237828 (-)
CAST/EiJ MGP_CASTEiJ_G0021279
protein coding gene Chr15:77245783-77489009 (-)
CBA/J MGP_CBAJ_G0021727
protein coding gene Chr15:82625619-82870326 (-)
DBA/2J MGP_DBA2J_G0021852
protein coding gene Chr15:73907759-74138049 (-)
FVB/NJ MGP_FVBNJ_G0021832
protein coding gene Chr15:72963258-73191933 (-)
LP/J MGP_LPJ_G0021923
protein coding gene Chr15:77286876-77527602 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0021857
protein coding gene Chr15:87942141-88182438 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0022448
protein coding gene Chr15:76658114-76892703 (-)
PWK/PhJ MGP_PWKPhJ_G0021020
protein coding gene Chr15:74076249-74309986 (-)
SPRET/EiJ MGP_SPRETEiJ_G0020860
protein coding gene Chr15:76378062-76620573 (-)
WSB/EiJ MGP_WSBEiJ_G0021331
protein coding gene Chr15:76764409-76999344 (-)



Homology
more
  • Human Ortholog
    RBFOX2, RNA binding fox-1 homolog 2
  • Vertebrate Orthologs
    7
  • Human Ortholog
    RBFOX2, RNA binding fox-1 homolog 2
    Orthology source: HomoloGene, HGNC
  • Synonyms
    dJ106I20.3, Fox-2, FOX2, fxh, HNRBP2, HRNBP2, RBM9, RTA
  • Links
    NCBI Gene ID: 23543
    neXtProt AC: NX_O43251
    UniProt: O43251

  • Chr Location
    22q12.3; chr22:35738736-36028892 (-)  GRCh38.p7

Human Diseases
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  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    15 phenotypes from 1 allele in 1 genetic background
    10 phenotypes from multigenic genotypes
    35 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a conditional allele activated in the brain exhibit normal spontaneous and kainic acid-induced seizures.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000033565 Ensembl Gene Model | MGI Sequence Detail 228015 C57BL/6J ±  kb
    transcript ENSMUST00000171751 Ensembl | MGI Sequence Detail 6907 Not Applicable  
    polypeptide ENSMUSP00000130739 Ensembl | MGI Sequence Detail 449 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 21
      Genomic 1
      cDNA 16
      Primer pair 4

      Microarray probesets 9
    Other
    Accession IDs
    less
    MGI:1920085, MGI:2145891, MGI:2145951, MGI:894685
    References
    more
    • Summaries
      All 88
      Developmental Gene Expression 12
      Diseases 1
      Gene Ontology 13
      Phenotypes 35
    • Earliest
      J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
    • Latest
      J:263841 Gu L, et al., Downregulation of splicing regulator RBFOX1 compromises visual depth perception. PLoS One. 2018;13(7):e0200417

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
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    last database update
    11/06/2018
    MGI 6.13
    The Jackson Laboratory