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Mcam
Gene Detail
Symbol

Name
ID
Mcam
melanoma cell adhesion molecule
MGI:1933966
Synonyms
1-gicerin, CD146, Muc18, s-endo, s-gicerin
Feature Type
protein coding gene
Genetic Map
Chromosome 9
24.68 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr9:44134469-44142727 bp, + strand
From VEGA annotation of GRCm38

  8259 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:4742  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 dog; 1 chicken; 1 western clawed frog; 3 zebrafish

Protein SuperFamily: VVC2C2C2 Ig-like domain arrangement-containing protein
Gene Tree: Mcam

Human
homologs
Human Homolog MCAM, melanoma cell adhesion molecule
NCBI Gene ID 4162
neXtProt AC  NX_P43121
Human Synonyms  CD146, MUC18
Human Chr (Location)  11q23.3; chr11:119308524-119318377 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(5) : Gene trapped(1) Targeted(4)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a conditional allele activated in endothelial cells exhibit impaired VEGF-induced angiogenesis in Matrigel.
 
Interactions
Mcam interacts with 150 markers (Mir7-1, Mir15a, Mir15b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (11 annotations)
Process angiogenesis, cell adhesion, ...
Component external side of plasma membrane, extracellular space, ...
External Resources: FuncBase
Expression
Literature Summary: (2 records)
cDNA source data(7)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(7) cDNA(7)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000016731 (Evidence)
Ensembl Gene ModelENSMUSG00000032135 (Evidence)
Entrez Gene84004 (Evidence)
DFCITC1574887, TC1593314
DoTSDT.87072633, DT.97413384
NIA Mouse Gene IndexU010379
Consensus CDS ProjectCCDS23097.1
International Mouse Knockout Project StatusMcam
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000016731 VEGA Gene Model | MGI Sequence Detail 8259 C57BL/6J ±  kb
transcript OTTMUST00000040547 VEGA | MGI Sequence Detail 2989 Not Applicable 
polypeptide OTTMUSP00000018124 VEGA | MGI Sequence Detail 648 Not Applicable 

For the selected sequences
All sequences(54) RefSeq(6) UniProt(5)
Polymorphisms
SNPs within 2kb(54 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR013162 CD80-like, immunoglobulin C2-set
InterPro IPR013098 Immunoglobulin I-set
InterPro IPR007110 Immunoglobulin-like domain
InterPro IPR013783 Immunoglobulin-like fold
InterPro IPR003599 Immunoglobulin subtype
InterPro IPR003598 Immunoglobulin subtype 2
InterPro IPR013106 Immunoglobulin V-set
Protein Ontology PR:000001127 cell surface glycoprotein MUC18
References
(Earliest) J:68338 Yang H, et al., Isolation and characterization of mouse MUC18 cDNA gene, and correlation of MUC18 expression in mouse melanoma cell lines with metastatic ability. Gene. 2001 Mar 7;265(1-2):133-45
(Latest) J:210618 Zeng Q, et al., Impaired tumor angiogenesis and VEGF-induced pathway in endothelial CD146 knockout mice. Protein Cell. 2014 Jun;5(6):445-56
All references(45)
Other
accession IDs
MGI:2143253

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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Funding Information
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last database update
11/18/2014
MGI 5.20
The Jackson Laboratory