Mcam
Gene Detail

Symbol Name ID

Mcam melanoma cell adhesion molecule MGI:1933966

Synonyms

1-gicerin, CD146, Muc18, s-endo, s-gicerin

Feature Type

protein coding gene

Genetic Map

Chromosome 9

24.68 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)

Sequence Map

Chr9:44134469-44142727 bp, + strand From VEGA annotation of GRCm38   8259 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:4742  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 dog; 1 chicken; 3 zebrafish

Protein SuperFamily: VVC2C2C2 Ig-like domain arrangement-containing protein
Gene Tree: Mcam

Human homologs

Human Homolog		MCAM, melanoma cell adhesion molecule
NCBI Gene ID		4162
neXtProt AC		NX_P43121
Human Synonyms		CD146, MUC18
Human Chr (Location)		11q23.3; chr11:119179234-119187840 (-)  GRCh37.p10

Alleles and phenotypes

All alleles(4) : Targeted(3) Gene trapped(1)
 

Mice homozygous for a conditional allele activated in endothelial cells exhibit impaired VEGF-induced angiogenesis in Matrigel.

 

Gene Ontology (GO) classifications

All GO classifications: (6 annotations)

Process	cell adhesion, heterophilic cell-cell adhesion
Component	external side of plasma membrane, integral to membrane, ...

External Resources: FuncBase

Expression

Literature Summary: (1 records)
cDNA source data(7)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(7) cDNA(7)
Microarray probesets(3)

Other database links

VEGA Gene Model	OTTMUSG00000016731 (Evidence)
Ensembl Gene Model	ENSMUSG00000032135 (Evidence)
Entrez Gene	84004 (Evidence)
DFCI	TC1574887, TC1593314
DoTS	DT.87072633, DT.97413384
NIA Mouse Gene Index	U010379
Consensus CDS Project	CCDS23097.1
International Mouse Knockout Project Status	Mcam

Sequences

Length	Strain/Species
genomic	OTTMUSG00000016731	VEGA Gene Model | MGI Sequence Detail	8259	C57BL/6J
transcript	OTTMUST00000040547	VEGA | MGI Sequence Detail	2989	Not Applicable
polypeptide	OTTMUSP00000018124	VEGA | MGI Sequence Detail	648	Not Applicable

All sequences(48) RefSeq(2) UniProt(3)

Polymorphisms

SNPs(29 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR013162	CD80-like, immunoglobulin C2-set
InterPro	IPR013098	Immunoglobulin I-set
InterPro	IPR007110	Immunoglobulin-like
InterPro	IPR013783	Immunoglobulin-like fold
InterPro	IPR003599	Immunoglobulin subtype
InterPro	IPR003598	Immunoglobulin subtype 2
InterPro	IPR013106	Immunoglobulin V-set
Protein Ontology	PR:000001127	cell surface glycoprotein MUC18

References

(Earliest) J:68338 Yang H, et al., Isolation and characterization of mouse MUC18 cDNA gene, and correlation of MUC18 expression in mouse melanoma cell lines with metastatic ability. Gene. 2001 Mar 7;265(1-2):133-45
(Latest) J:193167 Wu Q, et al., A Novel Function of MUC18: Amplification of Lung Inflammation during Bacterial Infection. Am J Pathol. 2013 Mar;182(3):819-27
All references(35)

Other accession IDs

MGI:2143253