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Mcam Gene Detail
Summary
  • Symbol
    Mcam
  • Name
    melanoma cell adhesion molecule
  • Synonyms
    1-gicerin, CD146, Muc18, s-endo, s-gicerin
  • Feature Type
    protein coding gene
  • IDs
    MGI:1933966
    NCBI Gene: 84004
  • Alliance
    gene page
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr9:44045946-44054024 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 9, 24.68 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    53 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1933966
 protein coding gene Chr9:44045766-44054024 (+)
129S1/SvImJ MGP_129S1SvImJ_G0034693
 protein coding gene Chr9:42598413-42605735 (+)
A/J MGP_AJ_G0034674
 protein coding gene Chr9:41422271-41430531 (+)
AKR/J MGP_AKRJ_G0034600
 protein coding gene Chr9:42282868-42292524 (+)
BALB/cJ MGP_BALBcJ_G0034665
 protein coding gene Chr9:41165391-41173651 (+)
C3H/HeJ MGP_C3HHeJ_G0034376
 protein coding gene Chr9:42736830-42744172 (+)
C57BL/6NJ MGP_C57BL6NJ_G0035186
 protein coding gene Chr9:43871366-43881143 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0032101
 protein coding gene Chr9:41013347-41020864 (+)
CAST/EiJ MGP_CASTEiJ_G0033698
 protein coding gene Chr9:42575824-42583167 (+)
CBA/J MGP_CBAJ_G0034348
 protein coding gene Chr9:45459548-45477820 (+)
DBA/2J MGP_DBA2J_G0034507
 protein coding gene Chr9:41333396-41343052 (+)
FVB/NJ MGP_FVBNJ_G0034448
 protein coding gene Chr9:40582829-40590171 (+)
LP/J MGP_LPJ_G0034588
 protein coding gene Chr9:42901380-42908702 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0034492
 protein coding gene Chr9:47327732-47335074 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0035207
 protein coding gene Chr9:42175720-42183978 (+)
PWK/PhJ MGP_PWKPhJ_G0033404
 protein coding gene Chr9:41199768-41207145 (+)
SPRET/EiJ MGP_SPRETEiJ_G0033238
 protein coding gene Chr9:42475376-42483790 (+)
WSB/EiJ MGP_WSBEiJ_G0033811
 protein coding gene Chr9:42213281-42220623 (+)



Homology
more
  • Human Ortholog
    MCAM, melanoma cell adhesion molecule
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    MCAM, melanoma cell adhesion molecule
  • Synonyms
    CD146, HEMCAM, MelCAM, METCAM, MUC18
  • Links
    NCBI Gene ID: 4162
    neXtProt AC: NX_P43121
    UniProt: P43121

  • Chr Location
    11q23.3; chr11:119308529-119321521 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    7 phenotypes from 3 alleles in 3 genetic backgrounds
    28 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a conditional allele activated in endothelial cells exhibit impaired VEGF-induced angiogenesis in Matrigel.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    13
  • GO References
    7
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    838
  • Tissues
    53
  • cDNA Data
    8
  • Literature Summary
    20
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 84004 NCBI Gene Model | MGI Sequence Detail 8079 C57BL/6J ±  kb
    transcript NM_023061 RefSeq | MGI Sequence Detail 2890 C57BL/6  
    polypeptide Q8R2Y2 UniProt | EBI | MGI Sequence Detail 648 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 9
      cDNA 8
      Other 1

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGI:2143253
    References
    more
    • Summaries
      All 83
      Developmental Gene Expression 20
      Gene Ontology 7
      Phenotypes 28
    • Earliest
      J:68338 Yang H, et al., Isolation and characterization of mouse MUC18 cDNA gene, and correlation of MUC18 expression in mouse melanoma cell lines with metastatic ability. Gene. 2001 Mar 7;265(1-2):133-45
    • Latest
      J:345613 Nikoloudaki G, et al., Assessing the fate and contribution of Foxd1-expressing embryonic precursors and their progeny in palatal development, homeostasis and excisional repair. Sci Rep. 2024 Feb 29;14(1):4969
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    04/16/2024
    MGI 6.23     		The Jackson Laboratory