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Mcam Gene Detail
Summary
  • Symbol
    Mcam
  • Name
    melanoma cell adhesion molecule
  • Synonyms
    1-gicerin, CD146, Muc18, s-endo, s-gicerin
  • Feature Type
    protein coding gene
  • IDs
    MGI:1933966
    NCBI Gene: 84004
  • Gene Overview
    MyGene.info: MCAM
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr9:44134469-44142727 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      8259 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 9, 24.68 cM
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    MCAM, melanoma cell adhesion molecule
  • Vertebrate Orthologs
    10
  • Human Ortholog
    MCAM, melanoma cell adhesion molecule
    Orthology source: HomoloGene, HGNC
  • Synonyms
    CD146, MUC18
  • Links
    NCBI Gene ID: 4162
    neXtProt AC: NX_P43121
    UniProt: P43121

  • Chr Location
    11q23.3; chr11:119308524-119317132 (-)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    6 phenotypes from 3 alleles in 3 genetic backgrounds
    18 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a conditional allele activated in endothelial cells exhibit impaired VEGF-induced angiogenesis in Matrigel.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
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    Sequences &
    Gene Models
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    Representative SequencesLengthStrain/SpeciesFlank
    genomic OTTMUSG00000016731 VEGA Gene Model | MGI Sequence Detail 8259 C57BL/6J ±  kb
    transcript OTTMUST00000040547 VEGA | MGI Sequence Detail 2989 Not Applicable  
    polypeptide OTTMUSP00000018124 VEGA | MGI Sequence Detail 648 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      54 from dbSNP Build 142
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 8
      cDNA 8

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGI:2143253
    References
    more
    • Summaries
      All 55
      Developmental Gene Expression 8
      Gene Ontology 5
      Phenotypes 18
    • Earliest
      J:68338 Yang H, et al., Isolation and characterization of mouse MUC18 cDNA gene, and correlation of MUC18 expression in mouse melanoma cell lines with metastatic ability. Gene. 2001 Mar 7;265(1-2):133-45
    • Latest
      J:253913 Guimaraes-Camboa N, et al., Pericytes of Multiple Organs Do Not Behave as Mesenchymal Stem Cells In Vivo. Cell Stem Cell. 2017 Mar 2;20(3):345-359.e5

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    07/31/2018
    MGI 6.12
    The Jackson Laboratory