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Mcam Gene Detail
Summary
  • Symbol
    Mcam
  • Name
    melanoma cell adhesion molecule
  • Synonyms
    1-gicerin, CD146, Muc18, s-endo, s-gicerin
  • Feature Type
    protein coding gene
  • IDs
    MGI:1933966
    NCBI Gene: 84004
  • Gene Overview
    MyGene.info: MCAM
Location & Maps
more
  • Sequence Map
    Chr9:44134469-44142727 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      8259 bp   ±  kb flank

  • Genome Browsers
Homology
more
  • Human Ortholog
    MCAM, melanoma cell adhesion molecule
  • Vertebrate Orthologs
    10
  • Human Ortholog
    MCAM, melanoma cell adhesion molecule
    Orthology source: HGNC, HomoloGene
  • Synonyms
    CD146, MUC18
  • Links
    NCBI Gene ID: 4162
    neXtProt AC: NX_P43121

  • Chr Location
    11q23.3; chr11:119308524-119317130 (-)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    5 phenotypes from 3 alleles in 3 genetic backgrounds
    15 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryogenesis
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
tumorigenesis
vision/eye

Click cells to view annotations.
Mice homozygous for a conditional allele activated in endothelial cells exhibit impaired VEGF-induced angiogenesis in Matrigel.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000016731 VEGA Gene Model | MGI Sequence Detail 8259 C57BL/6J ±  kb
transcript OTTMUST00000040547 VEGA | MGI Sequence Detail 2989 Not Applicable  
polypeptide OTTMUSP00000018124 VEGA | MGI Sequence Detail 648 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    54 from dbSNP Build 142
Protein
Information
less
Molecular
Reagents
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  • All nucleic 7
    cDNA 7

    Microarray probesets 3
Other
Accession IDs
less
MGI:2143253
References
more
  • Summaries
    All 45
    Developmental Gene Expression 2
    Gene Ontology 5
    Phenotypes 15
  • Earliest
    J:68338 Yang H, et al., Isolation and characterization of mouse MUC18 cDNA gene, and correlation of MUC18 expression in mouse melanoma cell lines with metastatic ability. Gene. 2001 Mar 7;265(1-2):133-45
  • Latest
    J:222474 Jouve N, et al., CD146 mediates VEGF-induced melanoma cell extravasation through FAK activation. Int J Cancer. 2015 Jul 1;137(1):50-60

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
04/19/2016
MGI 6.03
The Jackson Laboratory