Syt13 MGI Mouse Gene Detail - MGI:1933945

Symbol

Syt13
Name

synaptotagmin XIII
Synonyms

5730409J20Rik

Feature Type

protein coding gene
IDs

MGI:1933945
NCBI Gene: 80976
Alliance

genome feature page
Transcription Start Sites

9 TSS

Sequence Map

Chr2:92745446-92786403 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 2, 51.37 cM, cytoband E1
Mapping Data

3 experiments

SNPs within 2kb

1269 from dbSNP Build 142
Strain Annotations

19

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1933945	protein coding gene	Chr2:92745443-92786403 (+)
129S1/SvImJ	ENSMUSG00200052843	protein coding gene	Chr2:89662319-89703282 (+)
A/J	ENSMUSG00195052061	protein coding gene	Chr2:89798775-89839878 (+)
AKR/J	ENSMUSG00220052298	protein coding gene	Chr2:89594533-89636052 (+)
BALB/cJ	ENSMUSG00180054721	protein coding gene	Chr2:89696994-89737964 (+)
C3H/HeJ	ENSMUSG00175053327	protein coding gene	Chr2:89959129-90000647 (+)
C57BL/6NJ	ENSMUSG00215053197	protein coding gene	Chr2:89789547-89830506 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0023983	protein coding gene	Chr2:87047718-87088948 (+)
CAST/EiJ	ENSTCUG00005050001	protein coding gene	Chr2:89207945-89248624 (+)
CBA/J	ENSMUSG00210034384	protein coding gene	Chr2:89969481-90010449 (+)
DBA/2J	ENSMUSG00185056305	protein coding gene	Chr2:89693367-89734328 (+)
FVB/NJ	ENSMUSG00205047589	protein coding gene	Chr2:88981038-89022555 (+)
JF1/MsJ	ENSUMUG00000030810	protein coding gene	Chr2:89515495-89556029 (+)
LP/J	ENSMUSG00230040195	protein coding gene	Chr2:91443857-91484818 (+)
NOD/ShiLtJ	ENSMUSG00190032719	protein coding gene	Chr2:89771986-89812948 (+)
NZO/HlLtJ	ENSMUSG00225051577	protein coding gene	Chr2:99357764-99398776 (+)
PWK/PhJ	ENSLUMG00010043955	protein coding gene	Chr2:89491312-89531901 (+)
SPRET/EiJ	ENSMSPG00010052024	protein coding gene	Chr2:91457237-91495678 (+)
WSB/EiJ	ENSIUOG00005053343	protein coding gene	Chr2:89496546-89537742 (+)

Human Ortholog

SYT13, synaptotagmin 13

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

SYT13, synaptotagmin 13
Links

HGNC:14962

NCBI Gene ID: 57586

UniProt: Q7L8C5
Chr Location

11p11.2; chr11:45240302-45286341 (-) GRCh38

MGI Vertebrate Homology

Syt13 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: SYT13
Gene Tree

Syt13

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Phenotype Summary

3 phenotypes from 2 alleles in 1 genetic background
15 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

18
Chemically induced (other)

1
Endonuclease-mediated

7
Gene trapped

2
Radiation induced

1
Targeted

7
Genomic Mutations

4 involving Syt13
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

21 strains or lines available

Homozygous null mice exhibit postnatal lethality with altered epithelial organization of the pancreas, impaired pancreas endocrine cell egression and increased alpha-to-beta-cell ratio.

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All GO Annotations

20
GO References

6

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

1054
Tissues

176
cDNA Data

54
Literature Summary

14

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GENSAT

GEO

Expression Atlas
Other Vertebrate Links

Xenbase syt13

ZFIN syt13

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All Sequences

39
RefSeq

2
UniProt

1
CCDS

CCDS16451.1

Ensembl

ENSMUSG00000027220 (Evidence)
NCBI Gene

80976

			Length	Strain/Species	Flank
genomic	80976	NCBI Gene Model \| MGI Sequence Detail	40958	C57BL/6J	± kb
transcript	NM_030725	RefSeq \| MGI Sequence Detail	3758	C57BL/6
polypeptide	Q9EQT6	UniProt \| EBI \| MGI Sequence Detail	426	Not Applicable

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UniProt

1 Sequence
Protein Ontology

PR:000015898 synaptotagmin-13

(term hierarchy)
InterPro Domains

IPR000008 C2 domain

IPR035892 C2 domain superfamily

IPR028692 Synaptotagmin-13, C2B domain

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All nucleic 59

cDNA 54

Primer pair 3

Other 2

Microarray probesets 5

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MGI:1917750, MGI:2139000

Summaries

All 54

Developmental Gene Expression 14

Gene Ontology 6

Phenotypes 15
Earliest

J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
Latest

J:354049 Pulcrano S, et al., miR-218 Promotes Dopaminergic Differentiation and Controls Neuron Excitability and Neurotransmitter Release through the Regulation of a Synaptic-Related Genes Network. J Neurosci. 2023 Nov 29;43(48):8104-8125

TSS for Syt13:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr18965	Chr2:92745396-92745411 (+)	-42 bp
Tssr570	Chr2:92745413-92745416 (+)	-31 bp
Tssr18966	Chr2:92745425-92745460 (+)	-3 bp
Tssr18967	Chr2:92745467-92745472 (+)	24 bp
Tssr18968	Chr2:92745476-92745487 (+)	36 bp
Tssr18969	Chr2:92776415-92776452 (+)	30,988 bp
Tssr18970	Chr2:92782471-92782476 (+)	37,028 bp
Tssr18971	Chr2:92784822-92784831 (+)	39,381 bp
Tssr18972	Chr2:92784912-92784923 (+)	39,472 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 09/08/2026 MGI 6.24