About   Help   FAQ
Nrg4
Gene Detail
 Symbol
Name
ID
Nrg4
neuregulin 4
MGI:1933833
Feature Type protein coding gene
Genetic Map
Chromosome 9
29.87 cM, cytoband C
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr9:55220222-55326844 bp, - strand
From VEGA annotation of GRCm38

  106623 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:12921  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 chicken

Gene Tree: Nrg4

Human
homologs
Human Homolog NRG4, neuregulin 4
NCBI Gene ID 145957
neXtProt AC  NX_Q8WWG1
Human Synonyms  HRG4
Human Chr (Location)  15q24.2; chr15:75941973-76012444 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(25) : Gene trapped(23) Targeted(2)
 
A gene trap insertion into an intron of this gene results in no obvious phenotype.
 
Interactions
Nrg4 interacts with 243 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (5 annotations)
Component extracellular region, integral component of membrane, ...
Function growth factor activity
External Resources: FuncBase
Expression
Literature Summary: (5 records)
Data Summary: Results (8)    Tissues (4)   
Theiler Stages: 28
Assay TypeResults
RNA in situ 6
RT-PCR 2
cDNA source data(8)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(13) cDNA(11) Primer pair(1) Other(1)
Microarray probesets(4)
Other database
links
VEGA Gene ModelOTTMUSG00000024543 (Evidence)
Ensembl Gene ModelENSMUSG00000032311 (Evidence)
Entrez Gene83961 (Evidence)
NIA Mouse Gene IndexU030899
Consensus CDS ProjectCCDS52801.1
International Mouse Knockout Project StatusNrg4
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000024543 VEGA Gene Model | MGI Sequence Detail 106623 C57BL/6J ±  kb
transcript OTTMUST00000060268 VEGA | MGI Sequence Detail 1000 Not Applicable 
polypeptide OTTMUSP00000029389 VEGA | MGI Sequence Detail 115 Not Applicable 

For the selected sequences
All sequences(62) RefSeq(8) UniProt(4)
Polymorphisms SNPs within 2kb(546 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR013032 EGF-like, conserved site
InterPro IPR000742 Epidermal growth factor-like domain
Protein Ontology PR:000011425 pro-neuregulin-4, membrane-bound isoform
References (Earliest) J:66947 Harari D, et al., Neuregulin-4: a novel growth factor that acts through the ErbB-4 receptor tyrosine kinase. Oncogene. 1999 Apr 29;18(17):2681-9
(Latest) J:175386 Maier H, et al., Normal fur development and sebum production depends on fatty acid 2-hydroxylase expression in sebaceous glands. J Biol Chem. 2011 Jul 22;286(29):25922-34
All references(34)
Other
accession IDs
MGI:2143092

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
08/26/2014
MGI 5.19
The Jackson Laboratory