Nrg4
Gene Detail

Symbol Name ID

Nrg4 neuregulin 4 MGI:1933833

Feature Type

protein coding gene

Genetic Map

Chromosome 9

29.87 cM, cytoband C
Detailed Genetic Map ± 1 cM


Mapping data(3)

Sequence Map

Chr9:55220222-55326844 bp, - strand From VEGA annotation of GRCm38   106623 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Mammalian homology

human; rat; cattle; chimpanzee    (Mammalian Orthology)
Comparative Map (Mouse/Human Nrg4 ± 2 cM)

Gene Tree: Nrg4

Human ortholog

NRG4 neuregulin 4 NCBI Gene ID 145957
Human Synonyms: HRG4
Human Chr15:76234314-76304785 bp, - strand Reference GRCh37.p2 Primary Assembly

Alleles and phenotypes

All alleles(25) : Targeted(2) Gene trapped(23)
 

A gene trap insertion into an intron of this gene results in no obvious phenotype.

 

Gene Ontology (GO) classifications

All GO classifications: (5 annotations)

Component	extracellular region, integral to membrane, ...
Function	growth factor activity

External Resources: FuncBase

Expression

Literature Summary: (5 records)
Data Summary: Results (8)    Tissues (4)   
Theiler Stages: 28

Assay Type	Results
RNA in situ	6
RT-PCR	2

cDNA source data(8)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(13) cDNA(11) Primer pair(1) Other(1)
Microarray probesets(4)

Other database links

VEGA Gene Model	OTTMUSG00000024543 (Evidence)
Ensembl Gene Model	ENSMUSG00000032311 (Evidence)
Entrez Gene	83961 (Evidence)
NIA Mouse Gene Index	U030899
Consensus CDS Project	CCDS52801.1
International Mouse Knockout Project Status	Nrg4

Sequences

Length	Strain/Species
genomic	OTTMUSG00000024543	VEGA Gene Model | MGI Sequence Detail	106623	C57BL/6J
transcript	OTTMUST00000060268	VEGA | MGI Sequence Detail	1000	Not Applicable
polypeptide	OTTMUSP00000029389	VEGA | MGI Sequence Detail	115	Not Applicable

All sequences(65) RefSeq(2) UniProt(7)

Polymorphisms

SNPs(93 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR013032	EGF-like, conserved site
InterPro	IPR000742	Epidermal growth factor-like domain
Protein Ontology	PR:000011425	pro-neuregulin-4, membrane-bound isoform

References

(Earliest) J:66947 Harari D, et al., Neuregulin-4: a novel growth factor that acts through the ErbB-4 receptor tyrosine kinase. Oncogene. 1999 Apr 29;18(17):2681-9
(Latest) J:175386 Maier H, et al., Normal fur development and sebum production depends on fatty acid 2-hydroxylase expression in sebaceous glands. J Biol Chem. 2011 Jul 22;286(29):25922-34
All references(34)

Other accession IDs

MGI:2143092