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Enpp5 Gene Detail
Summary
  • Symbol
    Enpp5
  • Name
    ectonucleotide pyrophosphatase/phosphodiesterase 5
  • Synonyms
    D17Abb1e
  • Feature Type
    protein coding gene
  • IDs
    MGI:1933830
    NCBI Gene: 83965
  • Alliance
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr17:44078846-44086567 bp, + strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 17, 20.30 cM, cytoband C
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    97 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1933830
protein coding gene Chr17:44078813-44086567 (+)
129S1/SvImJ MGP_129S1SvImJ_G0023781
protein coding gene Chr17:45011698-45019386 (+)
A/J MGP_AJ_G0023739
protein coding gene Chr17:43975630-43983367 (+)
AKR/J MGP_AKRJ_G0023710
protein coding gene Chr17:44242391-44250126 (+)
BALB/cJ MGP_BALBcJ_G0023743
protein coding gene Chr17:43855428-43863050 (+)
C3H/HeJ MGP_C3HHeJ_G0023507
protein coding gene Chr17:44952386-44960121 (+)
C57BL/6NJ MGP_C57BL6NJ_G0024186
protein coding gene Chr17:47007276-47015030 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0021636
protein coding gene Chr17:40798391-40806620 (+)
CAST/EiJ MGP_CASTEiJ_G0022988
protein coding gene Chr17:44997450-45005155 (+)
CBA/J MGP_CBAJ_G0023483
protein coding gene Chr17:48653170-48660884 (+)
DBA/2J MGP_DBA2J_G0023609
protein coding gene Chr17:42779957-42787683 (+)
FVB/NJ MGP_FVBNJ_G0023576
protein coding gene Chr17:42349458-42357161 (+)
LP/J MGP_LPJ_G0023690
protein coding gene Chr17:45669715-45677428 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0023605
protein coding gene Chr17:48280092-48288572 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0024231
protein coding gene Chr17:44592479-44600163 (+)
PWK/PhJ MGP_PWKPhJ_G0022733
protein coding gene Chr17:42043412-42051427 (+)
SPRET/EiJ MGP_SPRETEiJ_G0022548
protein coding gene Chr17:41455403-41463023 (+)
WSB/EiJ MGP_WSBEiJ_G0023053
protein coding gene Chr17:45112723-45120410 (+)



Homology
more
  • Human Ortholog
    ENPP5, ectonucleotide pyrophosphatase/phosphodiesterase family member 5
  • Vertebrate Orthologs
    8
  • Human Ortholog
    ENPP5, ectonucleotide pyrophosphatase/phosphodiesterase family member 5
    Orthology source: HomoloGene, HGNC
  • Synonyms
    NPP5, NPP-5
  • Links
    NCBI Gene ID: 59084
    neXtProt AC: NX_Q9UJA9
    UniProt: Q9UJA9

  • Chr Location
    6p21.1; chr6:46159182-46171045 (-)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    4 phenotype references
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 83965 NCBI Gene Model | MGI Sequence Detail 7722 C57BL/6J ±  kb
transcript NM_001329619 RefSeq | MGI Sequence Detail 4886 C57BL/6  
polypeptide Q9EQG7 UniProt | EBI | MGI Sequence Detail 477 Not Applicable  
For the selected sequence
Protein
Information
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  • UniProt
    4 Sequences
  • Protein Ontology
    PR:000007089 ectonucleotide pyrophosphatase/phosphodiesterase family member 5
  • PDB
  • EC
  • InterPro Domains
    IPR017849 Alkaline phosphatase-like, alpha/beta/alpha
    IPR017850 Alkaline-phosphatase-like, core domain superfamily
    IPR002591 Type I phosphodiesterase/nucleotide pyrophosphatase/phosphate transferase
Molecular
Reagents
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  • All nucleic 10
    cDNA 9
    Primer pair 1

    Microarray probesets 4
Other
Accession IDs
less
MGD-MRK-33094, MGI:105422, MGI:2147042
References
more
  • Summaries
    All 30
    Developmental Gene Expression 2
    Gene Ontology 4
    Phenotypes 4
  • Earliest
    J:34960 Chambers DM, et al., Isolation and mapping of novel mouse brain cDNA clones containing trinucleotide repeats, and demonstration of novel alleles in recombinant inbred strains. Genome Res. 1996 Aug;6(8):715-23
  • Latest
    J:262823 Kasowitz SD, et al., Nuclear m6A reader YTHDC1 regulates alternative polyadenylation and splicing during mouse oocyte development. PLoS Genet. 2018 May;14(5):e1007412

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
03/13/2019
MGI 6.13
The Jackson Laboratory