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Nedd4l
Gene Detail
Symbol

Name
ID
Nedd4l
neural precursor cell expressed, developmentally down-regulated gene 4-like
MGI:1933754
Synonyms
1300012C07Rik, Nedd4-2, Nedd4b
Feature Type
protein coding gene
Genetic Map
Chromosome 18
37.57 cM, cytoband E1
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr18:64887756-65217826 bp, + strand
From NCBI annotation of GRCm38

  330071 bp   ±  kb flank

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Mouse Genome Browser
Vertebrate
homology
HomoloGene:86986  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: E3 ubiquitin-protein ligase, SMURF1 type
Gene Tree: Nedd4l

Human
homologs
Human Homolog NEDD4L, neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase
NCBI Gene ID 23327
neXtProt AC  NX_Q96PU5
Human Synonyms  hNEDD4-2, NEDD4-2, NEDD4.2, RSP5
Human Chr (Location)  18q21.31; chr18:58044355-58401540 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(35) : Gene trapped(28) Spontaneous(1) Targeted(6)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a null mutation display salt sensitive hypertension and high salt diet induced cardiac hypertrophy. A spontaneous mutation results in overt diabetes insipidus. Mice homozygous for a knock-out allele exhibit neonatal lethality with primary atelectasis.
 
Interactions
Nedd4l interacts with 446 markers (Mir1a-1, Mir1a-2, Mir7-1, ...)
Expression
Literature Summary: (5 records)
Data Summary: Results (205)    Tissues (54)    Images (31)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 205
cDNA source data(14)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(15) cDNA(15)
Microarray probesets(7)
Other database
links
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 83814 NCBI Gene Model | MGI Sequence Detail 330071 C57BL/6J ±  kb
transcript NM_031881 RefSeq | MGI Sequence Detail 8212 Not Specified 
polypeptide Q8CFI0 UniProt | EBI | MGI Sequence Detail 1004 Not Applicable 

For the selected sequences
All sequences(108) RefSeq(35) UniProt(6)
Polymorphisms
SNPs within 2kb(3194 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR000008 C2 calcium-dependent membrane targeting
InterPro IPR024928 E3 ubiquitin-protein ligase, SMURF1 type
InterPro IPR000569 HECT
InterPro IPR001202 WW domain
Protein Ontology PR:000003191 E3 ubiquitin-protein ligase NEDD4-like
Graphical View of Protein Domain Structure
References
(Earliest) J:165247 Shubert SB, Investigation of an Inherited Diabetes Insipidus in BALB/cByJ Mice. The Jackson Laboratory Summer Student Program, Eva M. Eicher, Sponsor. 1995;:1-15
(Latest) J:210609 Yu T, et al., In vivo regulation of NGF-mediated functions by Nedd4-2 ubiquitination of TrkA. J Neurosci. 2014 Apr 23;34(17):6098-106
All references(62)
Other
accession IDs
MGI:1921413

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
10/08/2014
MGI 5.20
The Jackson Laboratory