Nedd4l
Gene Detail

Symbol Name ID

Nedd4l neural precursor cell expressed, developmentally down-regulated gene 4-like MGI:1933754

Synonyms

1300012C07Rik, Nedd4-2, Nedd4b

Feature Type

protein coding gene

Genetic Map

Chromosome 18

37.57 cM, cytoband E1
Detailed Genetic Map ± 1 cM


Mapping data(3)

Sequence Map

Chr18:64887756-65217826 bp, + strand From NCBI annotation of GRCm38   330071 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:86986  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: E3 ubiquitin-protein ligase, SMURF1 type
Gene Tree: Nedd4l

Human homologs

Human Homolog		NEDD4L, neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase
NCBI Gene ID		23327
neXtProt AC		NX_Q96PU5
Human Synonyms		hNEDD4-2, NEDD4-2, NEDD4.2, RSP5
Human Chr (Location)		18q21; chr18:58044355-58401540 (+)  GRCh38

Alleles and phenotypes

All alleles(35) : Targeted(6) Gene trapped(28) Spontaneous(1)
 

Mice homozygous for a null mutation display salt sensitive hypertension and high salt diet induced cardiac hypertrophy. A spontaneous mutation results in overt diabetes insipidus. Mice homozygous for a knock-out allele exhibit neonatal lethality with primary atelectasis.

 

Gene Ontology (GO) classifications

All GO classifications: (48 annotations)

Process	negative regulation of potassium ion transmembrane transport, negative regulation of potassium ion transmembrane transporter activity, ...
Component	cytoplasm, nucleus, ...
Function	ion channel binding, ligase activity, ...

This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase

Expression

Literature Summary: (5 records)

Data Summary: Results (205)    Tissues (54)    Images (31)
Theiler Stages: 19, 23, 28

Assay Type	Results
RNA in situ	205

cDNA source data(14)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(15) cDNA(15)
Microarray probesets(7)

Other database links

Ensembl Gene Model	ENSMUSG00000024589 (Evidence)
Entrez Gene	83814 (Evidence)
DFCI	TC1574530, TC1587743, TC1595072, TC1602256, TC1634149, TC1646725
DoTS	DT.101280535, DT.101291636, DT.101401373, DT.101739562, DT.101739563, DT.492525, DT.60103626, DT.91310992, DT.94124048, DT.94372409, DT.97403836
NIA Mouse Gene Index	U018823, U217433
EC	6.3.2.-
PDB	1WR3, 1WR4, 1WR7
Consensus CDS Project	CCDS29305.1, CCDS50309.1
International Mouse Knockout Project Status	Nedd4l

Sequences

Length	Strain/Species
genomic	83814	NCBI Gene Model | MGI Sequence Detail	330071	C57BL/6J
transcript	NM_031881	RefSeq | MGI Sequence Detail	8212	Not Specified
polypeptide	Q8CFI0	UniProt | EBI | MGI Sequence Detail	1004	Not Applicable

All sequences(108) RefSeq(35) UniProt(6)

Polymorphisms

SNPs within 2kb(3194 from dbSNP Build 137)

Protein-related information

Resource	ID	Description
InterPro	IPR000008	C2 calcium-dependent membrane targeting
InterPro	IPR024928	E3 ubiquitin-protein ligase, SMURF1 type
InterPro	IPR000569	HECT
InterPro	IPR001202	WW domain
Protein Ontology	PR:000003191	E3 ubiquitin-protein ligase NEDD4-like

Graphical View of Protein Domain Structure

References

(Earliest) J:165247 Shubert SB, Investigation of an Inherited Diabetes Insipidus in BALB/cByJ Mice. The Jackson Laboratory Summer Student Program, Eva M. Eicher, Sponsor. 1995;:1-15
(Latest) J:201824 Goh CP, et al., Ndfip1 expression in developing neurons indicates a role for protein ubiquitination by Nedd4 E3 ligases during cortical development. Neurosci Lett. 2013 Sep 13;
All references(58)

Other accession IDs

MGI:1921413