Nedd4l
Gene Detail

Symbol

Name
ID

Nedd4l
neural precursor cell expressed, developmentally down-regulated gene 4-like
MGI:1933754

Synonyms

1300012C07Rik, Nedd4-2, Nedd4b

Feature Type

protein coding gene

Genetic Map

Chromosome 18
37.57 cM, cytoband E1
Detailed Genetic Map ± 1 cM


Mapping data(3)

Sequence Map

Chr18:64887756-65217826 bp, + strand From Ensembl annotation of GRCm38   330071 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate
homology

HomoloGene:86986  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: E3 ubiquitin-protein ligase, SMURF1 type
Gene Tree: Nedd4l

Human
homologs

Human Homolog		NEDD4L, neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase
NCBI Gene ID		23327
neXtProt AC		NX_Q96PU5
Human Synonyms		hNEDD4-2, NEDD4-2, NEDD4.2, RSP5
Human Chr (Location)		18q21.31; chr18:58044355-58401540 (+)  GRCh38

Mutations,
alleles, and
phenotypes

All mutations/alleles(35) : Gene trapped(28) Spontaneous(1) Targeted(6)
Incidental mutations (data from Mutagenetix , APF )
 

Mice homozygous for a null mutation display salt sensitive hypertension and high salt diet induced cardiac hypertrophy. A spontaneous mutation results in overt diabetes insipidus. Mice homozygous for a knock-out allele exhibit neonatal lethality with primary atelectasis.

 

Interactions

Nedd4l interacts with 446 markers (Mir1a-1, Mir1a-2, Mir7-1, ...)

View All

Gene Ontology
(GO)
classifications

All GO classifications: (59 annotations)

Process	negative regulation of potassium ion transmembrane transport, negative regulation of potassium ion transmembrane transporter activity, ...
Component	cytoplasm, extracellular vesicular exosome, ...
Function	coenzyme F420-0 gamma-glutamyl ligase activity, coenzyme F420-2 alpha-glutamyl ligase activity, ...

This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase

Expression

Literature Summary: (6 records)

Data Summary: Results (205)    Tissues (54)    Images (31)    Tissue x Stage Matrix (view)

Assay Type	Results
RNA in situ	205

cDNA source data(14)
External Resources: Allen Institute   GEO   Expression Atlas

Molecular
reagents

All nucleic(15) cDNA(15)
Microarray probesets(7)

Other database
links

Ensembl Gene Model	ENSMUSG00000024589 (Evidence)
Entrez Gene	83814 (Evidence)
DFCI	TC1602256, TC1634149, TC1595072, TC1587743, TC1574530, TC1646725
DoTS	DT.492525, DT.101739563, DT.101280535, DT.101739562, DT.101291636, DT.101401373, DT.94124048, DT.91310992, DT.60103626, DT.97403836, DT.94372409
NIA Mouse Gene Index	U018823, U217433
EC	6.3.2.-
PDB	1WR3, 1WR7, 1WR4
Consensus CDS Project	CCDS29305.1, CCDS50309.1
International Mouse Knockout Project Status	Nedd4l

Sequences

Length	Strain/Species
genomic	ENSMUSG00000024589	Ensembl Gene Model | MGI Sequence Detail	330071	C57BL/6J
transcript	ENSMUST00000163516	Ensembl | MGI Sequence Detail	8163	Not Applicable
polypeptide	ENSMUSP00000132838	Ensembl | MGI Sequence Detail	976	Not Applicable

All sequences(106) RefSeq(33) UniProt(6)

Polymorphisms

SNPs within 2kb(3194 from dbSNP Build 137)

Protein-related
information

Resource	ID	Description
InterPro	IPR000008	C2 calcium-dependent membrane targeting
InterPro	IPR024928	E3 ubiquitin-protein ligase, SMURF1 type
InterPro	IPR000569	HECT
InterPro	IPR001202	WW domain
Protein Ontology	PR:000003191	E3 ubiquitin-protein ligase NEDD4-like

References

(Earliest) J:165247 Shubert SB, Investigation of an Inherited Diabetes Insipidus in BALB/cByJ Mice. The Jackson Laboratory Summer Student Program, Eva M. Eicher, Sponsor. 1995;:1-15
(Latest) J:216394 Hsia HE, et al., Ubiquitin E3 ligase Nedd4-1 acts as a downstream target of PI3K/PTEN-mTORC1 signaling to promote neurite growth. Proc Natl Acad Sci U S A. 2014 Sep 9;111(36):13205-10
All references(63)

Other
accession IDs

MGI:1921413