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Nedd4l Gene Detail
Summary
  • Symbol
    Nedd4l
  • Name
    neural precursor cell expressed, developmentally down-regulated gene 4-like
  • Synonyms
    1300012C07Rik, Nedd4-2, Nedd4b
  • Feature Type
    protein coding gene
  • IDs
    MGI:1933754
    NCBI Gene: 83814
  • Gene Overview
    MyGene.info: NEDD4L
Location & Maps
more
  • Sequence Map
    Chr18:64887756-65217826 bp, + strand
  • From Ensembl annotation of GRCm38

    Mouse Genome Browser
  • Download
    Sequence
      330071 bp   ±  kb flank

  • Genome Browsers
    VEGA | Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 18, 37.57 cM, cytoband E1
  • Mapping Data
    3 experiments
Homology
more
  • Human Ortholog
    NEDD4L, neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase
  • Vertebrate Orthologs
    10
  • Human Ortholog
    NEDD4L, neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase
    Orthology source: HomoloGene, HGNC
  • Synonyms
    hNEDD4-2, NEDD4-2, NEDD4.2, PVNH7, RSP5
  • Links
    NCBI Gene ID: 23327
    neXtProt AC: NX_Q96PU5
    UniProt: Q96PU5

  • Chr Location
    18q21.31; chr18:58044362-58401540 (+)  GRCh38.p7
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    42 phenotypes from 5 alleles in 6 genetic backgrounds
    27 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null mutation display salt sensitive hypertension and high salt diet induced cardiac hypertrophy. A spontaneous mutation results in overt diabetes insipidus. Mice homozygous for a knock-out allele exhibit neonatal lethality with primary atelectasis.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
    49
  • GO References
    13
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    213
  • Tissues
    55
  • cDNA Data
    15
  • Literature Summary
    8
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000024589 Ensembl Gene Model | MGI Sequence Detail 330071 C57BL/6J ±  kb
transcript ENSMUST00000163516 Ensembl | MGI Sequence Detail 8163 Not Applicable  
polypeptide ENSMUSP00000132838 Ensembl | MGI Sequence Detail 976 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    3185 from dbSNP Build 142
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 16
    cDNA 16

    Microarray probesets 7
Other
Accession IDs
less
MGI:1921413
References
more
  • Summaries
    All 70
    Developmental Gene Expression 8
    Gene Ontology 13
    Phenotypes 27
  • Earliest
    J:165247 Shubert SB, Investigation of an Inherited Diabetes Insipidus in BALB/cByJ Mice. The Jackson Laboratory Summer Student Program, Eva M. Eicher, Sponsor. 1995;:1-15
  • Latest
    J:242043 Zhu J, et al., Epilepsy-associated gene Nedd4-2 mediates neuronal activity and seizure susceptibility through AMPA receptors. PLoS Genet. 2017 Feb;13(2):e1006634
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
09/12/2017
MGI 6.10 		The Jackson Laboratory