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Nedd4l
Gene Detail
Symbol

Name
ID
Nedd4l
neural precursor cell expressed, developmentally down-regulated gene 4-like
MGI:1933754
Synonyms
1300012C07Rik, Nedd4-2, Nedd4b
Feature Type
protein coding gene
Genetic Map
Chromosome 18
37.57 cM, cytoband E1
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr18:64887756-65217826 bp, + strand
From NCBI annotation of GRCm38

  330071 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:86986  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: NEDD4L
Protein SuperFamily: E3 ubiquitin-protein ligase, SMURF1 type
Gene Tree: Nedd4l

Human
homologs
NEDD4L, neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase
Orthology source: HomoloGene, HGNC

IDs:
NCBI Gene ID: 23327
neXtProt AC: NX_Q96PU5

Human Synonyms: hNEDD4-2, NEDD4-2, NEDD4.2, RSP5

Human Chr (Location): 18q21.31; chr18:58044233-58401541 (+)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(35) : Gene trapped(28) Spontaneous(1) Targeted(6)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Mice homozygous for a null mutation display salt sensitive hypertension and high salt diet induced cardiac hypertrophy. A spontaneous mutation results in overt diabetes insipidus. Mice homozygous for a knock-out allele exhibit neonatal lethality with primary atelectasis.
 
Interactions
Nedd4l interacts with 445 markers (Mir1a-1, Mir1a-2, Mir7-1, ...)
Expression
Literature Summary: (6 records)
Data Summary: Results (205)    Tissues (54)    Images (31)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 205
cDNA source data(15)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase nedd4l ; ZFIN nedd4l    NEW 
Molecular
reagents
All nucleic(16) cDNA(16)
Microarray probesets(7)
Other database
links
Ensembl Gene Model ENSMUSG00000024589 (Evidence)
Entrez Gene 83814 (Evidence)
DFCI TC1574530, TC1602256, TC1595072, TC1587743, TC1646725, TC1634149
DoTS DT.101739563, DT.91310992, DT.60103626, DT.492525, DT.101739562, DT.97403836, DT.101291636, DT.94372409, DT.94124048, DT.101401373, DT.101280535
NIA Mouse Gene Index U217433, U018823
EC 6.3.2.-
PDB 1WR7, 1WR4, 1WR3
Consensus CDS Project CCDS29305.1, CCDS50309.1
International Mouse Phenotyping Consortium Status Nedd4l
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 83814 NCBI Gene Model | MGI Sequence Detail 330071 C57BL/6J ±  kb
transcript NM_031881 RefSeq | MGI Sequence Detail 8212 Not Specified 
polypeptide Q8CFI0 UniProt | EBI | MGI Sequence Detail 1004 Not Applicable 

For the selected sequences
All sequences(109) RefSeq(33) UniProt(6)
Polymorphisms
SNPs within 2kb(3194 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR000008 C2 calcium-dependent membrane targeting
InterPro IPR000569 HECT
InterPro IPR001202 WW domain
Protein Ontology PR:000003191 E3 ubiquitin-protein ligase NEDD4-like
Graphical View of Protein Domain Structure
References
(Earliest) J:165247 Shubert SB, Investigation of an Inherited Diabetes Insipidus in BALB/cByJ Mice. The Jackson Laboratory Summer Student Program, Eva M. Eicher, Sponsor. 1995;:1-15
(Latest) J:216394 Hsia HE, et al., Ubiquitin E3 ligase Nedd4-1 acts as a downstream target of PI3K/PTEN-mTORC1 signaling to promote neurite growth. Proc Natl Acad Sci U S A. 2014 Sep 9;111(36):13205-10
All references(62)
Other
accession IDs
MGI:1921413

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
05/20/2015
MGI 5.22
The Jackson Laboratory