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Nedd4l
Gene Detail
 Symbol
Name
ID
Nedd4l
neural precursor cell expressed, developmentally down-regulated gene 4-like
MGI:1933754
Synonyms 1300012C07Rik, Nedd4-2, Nedd4b
Feature Type protein coding gene
Genetic Map
Chromosome 18
37.57 cM, cytoband E1
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr18:64887756-65217826 bp, + strand
From NCBI annotation of GRCm38

  330071 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:86986  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: E3 ubiquitin-protein ligase, SMURF1 type
Gene Tree: Nedd4l

Human
homologs
Human Homolog NEDD4L, neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase
NCBI Gene ID 23327
neXtProt AC  NX_Q96PU5
Human Synonyms  hNEDD4-2, NEDD4-2, NEDD4.2, RSP5
Human Chr (Location)  18q21; chr18:58044355-58401540 (+)  GRCh38
Alleles
and
phenotypes
All alleles(35) : Targeted(6) Gene trapped(28) Spontaneous(1)
 
Mice homozygous for a null mutation display salt sensitive hypertension and high salt diet induced cardiac hypertrophy. A spontaneous mutation results in overt diabetes insipidus. Mice homozygous for a knock-out allele exhibit neonatal lethality with primary atelectasis.
 
Gene Ontology
(GO)
classifications
All GO classifications: (48 annotations)
Process negative regulation of potassium ion transmembrane transport, negative regulation of potassium ion transmembrane transporter activity, ...
Component cytoplasm, nucleus, ...
Function ion channel binding, ligase activity, ...
This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase
Expression
Literature Summary: (5 records)
Data Summary: Results (205)    Tissues (54)    Images (31)
Theiler Stages: 19, 23, 28
Assay TypeResults
RNA in situ 205
cDNA source data(14)
External Resources: Allen Institute   GEO   ArrayExpress
Molecular
reagents
All nucleic(15) cDNA(15)
Microarray probesets(7)
Other database
links
Ensembl Gene ModelENSMUSG00000024589 (Evidence)
Entrez Gene83814 (Evidence)
DFCITC1574530, TC1587743, TC1595072, TC1602256, TC1634149, TC1646725
DoTSDT.101280535, DT.101291636, DT.101401373, DT.101739562, DT.101739563, DT.492525, DT.60103626, DT.91310992, DT.94124048, DT.94372409, DT.97403836
NIA Mouse Gene IndexU018823, U217433
EC6.3.2.-
PDB1WR3, 1WR4, 1WR7
Consensus CDS ProjectCCDS29305.1, CCDS50309.1
International Mouse Knockout Project StatusNedd4l
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 83814 NCBI Gene Model | MGI Sequence Detail 330071 C57BL/6J ±  kb
transcript NM_031881 RefSeq | MGI Sequence Detail 8212 Not Specified 
polypeptide Q8CFI0 UniProt | EBI | MGI Sequence Detail 1004 Not Applicable 

For the selected sequences
All sequences(108) RefSeq(35) UniProt(6)
Polymorphisms SNPs within 2kb(3194 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR000008 C2 calcium-dependent membrane targeting
InterPro IPR024928 E3 ubiquitin-protein ligase, SMURF1 type
InterPro IPR000569 HECT
InterPro IPR001202 WW domain
Protein Ontology PR:000003191 E3 ubiquitin-protein ligase NEDD4-like
Graphical View of Protein Domain Structure
References (Earliest) J:165247 Shubert SB, Investigation of an Inherited Diabetes Insipidus in BALB/cByJ Mice. The Jackson Laboratory Summer Student Program, Eva M. Eicher, Sponsor. 1995;:1-15
(Latest) J:201824 Goh CP, et al., Ndfip1 expression in developing neurons indicates a role for protein ubiquitination by Nedd4 E3 ligases during cortical development. Neurosci Lett. 2013 Sep 13;
All references(58)
Other
accession IDs
MGI:1921413

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
04/08/2014
MGI 5.17
The Jackson Laboratory