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Actl6b
Gene Detail
Symbol

Name
ID
Actl6b
actin-like 6B
MGI:1933548
Synonyms
Actl6, ArpNa, Baf53b
Feature Type
protein coding gene
Genetic Map
Chromosome 5
76.56 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr5:137553517-137569582 bp, + strand
From VEGA annotation of GRCm38

  16066 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:81844  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog

Gene Tree: Actl6b

Human
homologs
Human Homolog ACTL6B, actin-like 6B
NCBI Gene ID 51412
neXtProt AC  NX_O94805
Human Synonyms  ACTL6, BAF53B
Human Chr (Location)  7q22; chr7:100643097-100656461 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(7) : Gene trapped(4) Targeted(3)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygotes for null mutations exhibit low survivor rate and most die within 2 days after birth and show hyperactivity due to reduced dendrite formation in neurons.
 
Interactions
Actl6b interacts with 74 markers (Mir1a-1, Mir1a-2, Mir15a, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (13 annotations)
Process chromatin assembly or disassembly, chromatin modification, ...
Component BAF-type complex, nBAF complex, ...
Function protein binding
External Resources: FuncBase
Expression
Literature Summary: (5 records)
Data Summary: Results (92)    Tissues (14)    Images (20)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 92
cDNA source data(15)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(15) cDNA(15)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000021924 (Evidence)
Ensembl Gene ModelENSMUSG00000029712 (Evidence)
Entrez Gene83766 (Evidence)
UniGene31646
DFCITC1579361
DoTSDT.480947
NIA Mouse Gene IndexU006321
Consensus CDS ProjectCCDS19770.1
International Mouse Knockout Project StatusActl6b
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000021924 VEGA Gene Model | MGI Sequence Detail 16066 C57BL/6J ±  kb
transcript OTTMUST00000052049 VEGA | MGI Sequence Detail 1592 Not Applicable 
polypeptide OTTMUSP00000024596 VEGA | MGI Sequence Detail 426 Not Applicable 

For the selected sequences
All sequences(59) RefSeq(14) UniProt(9)
Polymorphisms
SNPs within 2kb(62 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR004001 Actin, conserved site
InterPro IPR004000 Actin-related protein
Protein Ontology PR:000003683 actin-like protein 6B
References
(Earliest) J:67990 Wilson MD, et al., Comparative analysis of the gene-dense ACHE/TFR2 region on human chromosome 7q22 with the orthologous region on mouse chromosome 5. Nucleic Acids Res. 2001 Mar 15;29(6):1352-65
(Latest) J:212358 Singh AP, et al., Analysis of the SWI/SNF chromatin-remodeling complex during early heart development and BAF250a repression cardiac gene transcription during P19 cell differentiation. Nucleic Acids Res. 2014 Mar;42(5):2958-75
All references(38)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
11/18/2014
MGI 5.20
The Jackson Laboratory