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Tas1r3
Gene Detail
Symbol

Name
ID
Tas1r3
taste receptor, type 1, member 3
MGI:1933547
Synonyms
T1r3
Feature Type
protein coding gene
Genetic Map
Chromosome 4
87.65 cM
Detailed Genetic Map ± 1 cM


Mapping data(17)
Sequence Map
Chr4:155859268-155863362 bp, - strand
From VEGA annotation of GRCm38

  4095 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:12890  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 dog; 1 chicken; 1 zebrafish

HCOP human homology predictions: TAS1R3
Protein SuperFamily: metabotropic glutamate receptor-like protein
Gene Tree: Tas1r3

Human
homologs
TAS1R3, taste receptor, type 1, member 3
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 83756
neXtProt AC: NX_Q7RTX0

Human Synonyms: T1R3

Human Chr (Location): 1p36.33; chr1:1328999-1335320 (+)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(5) : Targeted(5)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Mutation of this locus affects taste perception. Complete inactivation results in diminished behavioral and nervous repsonses to both sweet and umami tastants.
 
Interactions
Tas1r3 interacts with 128 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Expression
Literature Summary: (4 records)
cDNA source data(4)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: ZFIN tas1r3    NEW 
Molecular
reagents
All nucleic(9) Genomic(3) cDNA(4) Other(2)
Microarray probesets(2)
Other database
links
VEGA Gene Model OTTMUSG00000010892 (Evidence)
Ensembl Gene Model ENSMUSG00000029072 (Evidence)
Entrez Gene 83771 (Evidence)
UniGene 358792
DFCI TC1590735
DoTS DT.94175600
NIA Mouse Gene Index U025884
Consensus CDS Project CCDS19046.1
International Mouse Phenotyping Consortium Status Tas1r3
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000010892 VEGA Gene Model | MGI Sequence Detail 4095 C57BL/6J ±  kb
transcript OTTMUST00000025532 VEGA | MGI Sequence Detail 3523 Not Applicable 
polypeptide OTTMUSP00000011689 VEGA | MGI Sequence Detail 858 Not Applicable 

For the selected sequences
All sequences(21) RefSeq(2) UniProt(1)
Polymorphisms
SNPs within 2kb(80 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR000337 GPCR, family 3
InterPro IPR017979 GPCR, family 3, conserved site
InterPro IPR017978 GPCR, family 3, C-terminal
InterPro IPR011500 GPCR, family 3, nine cysteines domain
InterPro IPR028082 Periplasmic binding protein-like I
InterPro IPR001828 Receptor, ligand binding region
Protein Ontology PR:000016062 taste receptor type 1 member 3
References
(Earliest) J:5474 Fuller JL, Single-locus control of saccharin preference in mice. J Hered. 1974 Jan-Feb;65(1):33-6
(Latest) J:217303 Koudelka J, et al., Genetic dissection of TrkB activated signalling pathways required for specific aspects of the taste system. Neural Dev. 2014;9:21
All references(80)
Other
accession IDs
MGD-MRK-14284, MGI:98226

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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Funding Information
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last database update
08/25/2015
MGI 6.0
The Jackson Laboratory