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Tas1r3
Gene Detail
 Symbol
Name
ID
Tas1r3
taste receptor, type 1, member 3
MGI:1933547
Synonyms T1r3
Feature Type protein coding gene
Genetic Map
Chromosome 4
87.65 cM
Detailed Genetic Map ± 1 cM


Mapping data(17)
Sequence Map
Chr4:155859268-155863362 bp, - strand
From VEGA annotation of GRCm38

  4095 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:12890  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: metabotropic glutamate receptor-like protein
Gene Tree: Tas1r3

Human
homologs
Human Homolog TAS1R3, taste receptor, type 1, member 3
NCBI Gene ID 83756
neXtProt AC  NX_Q7RTX0
Human Synonyms  T1R3
Human Chr (Location)  1p36.33; chr1:1330852-1334464 (+)  GRCh38
Alleles
and
phenotypes
All alleles(7) : Targeted(5)
Incidental mutations (data from Mutagenetix , APF )
 
Mutation of this locus affects taste perception. Complete inactivation results in diminished behavioral and nervous repsonses to both sweet and umami tastants.
 
Gene Ontology
(GO)
classifications
All GO classifications: (23 annotations)
Process detection of chemical stimulus involved in sensory perception of sweet taste, G-protein coupled receptor signaling pathway, ...
Component integral component of membrane, integral component of plasma membrane, ...
Function G-protein coupled receptor activity, protein binding, ...
External Resources: FuncBase
Expression
Literature Summary: (2 records)
cDNA source data(4)
External Resources: Allen Institute   GEO   ArrayExpress
Molecular
reagents
All nucleic(9) Genomic(3) cDNA(4) Other(2)
Microarray probesets(2)
Other database
links
VEGA Gene ModelOTTMUSG00000010892 (Evidence)
Ensembl Gene ModelENSMUSG00000029072 (Evidence)
Entrez Gene83771 (Evidence)
UniGene358792
DFCITC1590735
DoTSDT.94175600
NIA Mouse Gene IndexU025884
Consensus CDS ProjectCCDS19046.1
International Mouse Knockout Project StatusTas1r3
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000010892 VEGA Gene Model | MGI Sequence Detail 4095 C57BL/6J ±  kb
transcript OTTMUST00000025532 VEGA | MGI Sequence Detail 3523 Not Applicable 
polypeptide OTTMUSP00000011689 VEGA | MGI Sequence Detail 858 Not Applicable 

For the selected sequences
All sequences(21) RefSeq(2) UniProt(1)
Polymorphisms SNPs within 2kb(80 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001828 Extracellular ligand-binding receptor
InterPro IPR000337 GPCR, family 3
InterPro IPR017979 GPCR, family 3, conserved site
InterPro IPR017978 GPCR, family 3, C-terminal
InterPro IPR011500 GPCR, family 3, nine cysteines domain
Protein Ontology PR:000016062 taste receptor type 1 member 3
References (Earliest) J:5474 Fuller JL, Single-locus control of saccharin preference in mice. J Hered. 1974 Jan-Feb;65(1):33-6
(Latest) J:205002 Simon BR, et al., Artificial sweeteners stimulate adipogenesis and suppress lipolysis independently of sweet taste receptors. J Biol Chem. 2013 Nov 8;288(45):32475-89
All references(77)
Other
accession IDs
MGD-MRK-14284, MGI:98226

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
07/15/2014
MGI 5.18
The Jackson Laboratory