About   Help   FAQ
Tas1r3 Gene Detail
Summary
  • Symbol
    Tas1r3
  • Name
    taste receptor, type 1, member 3
  • Synonyms
    T1r3
  • Feature Type
    protein coding gene
  • IDs
    MGI:1933547
    NCBI Gene: 83771
  • Gene Overview
    MyGene.info: TAS1R3
Location & Maps
more
  • Sequence Map
    Chr4:155859268-155863362 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      4095 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 4, 87.65 cM
  • Mapping Data
    17 experiments
Homology
more
  • Human Ortholog
    TAS1R3, taste 1 receptor member 3
  • Vertebrate Orthologs
    8
  • Human Ortholog
    TAS1R3, taste 1 receptor member 3
    Orthology source: HomoloGene, HGNC
  • Synonyms
    T1R3
  • Links
    NCBI Gene ID: 83756
    neXtProt AC: NX_Q7RTX0

  • Chr Location
    1p36.33; chr1:1328999-1335320 (+)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    4 phenotypes from 3 alleles in 3 genetic backgrounds
    2 phenotypes from multigenic genotypes
    41 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mutation of this locus affects taste perception. Complete inactivation results in diminished behavioral and nervous repsonses to both sweet and umami tastants.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000010892 VEGA Gene Model | MGI Sequence Detail 4095 C57BL/6J ±  kb
transcript OTTMUST00000025532 VEGA | MGI Sequence Detail 3523 Not Applicable  
polypeptide OTTMUSP00000011689 VEGA | MGI Sequence Detail 858 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    79 from dbSNP Build 142
Protein
Information
less
  • UniProt
    1 Sequence
  • Protein Ontology
    PR:000016062 taste receptor type 1 member 3
  • InterPro Domains
    IPR000337 GPCR, family 3
    IPR017979 GPCR, family 3, conserved site
    IPR017978 GPCR family 3, C-terminal
    IPR011500 GPCR, family 3, nine cysteines domain
    IPR028082 Periplasmic binding protein-like I
    IPR001828 Receptor, ligand binding region
Molecular
Reagents
less
  • All nucleic 10
    Genomic 3
    cDNA 5
    Other 2

    Microarray probesets 2
Other
Accession IDs
less
MGD-MRK-14284, MGI:98226
References
more
  • Summaries
    All 84
    Developmental Gene Expression 5
    Gene Ontology 6
    Phenotypes 41
  • Earliest
    J:5474 Fuller JL, Single-locus control of saccharin preference in mice. J Hered. 1974 Jan-Feb;65(1):33-6
  • Latest
    J:232176 Sukumaran SK, et al., Taste cell-expressed alpha-glucosidase enzymes contribute to gustatory responses to disaccharides. Proc Natl Acad Sci U S A. 2016 May 24;113(21):6035-40

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
09/13/2016
MGI 6.05
The Jackson Laboratory