Tas1r3
Gene Detail

Symbol Name ID

Tas1r3 taste receptor, type 1, member 3 MGI:1933547

Synonyms

T1r3

Feature Type

protein coding gene

Genetic Map

Chromosome 4

87.65 cM
Detailed Genetic Map ± 1 cM


Mapping data(17)

Sequence Map

Chr4:155859268-155863362 bp, - strand From VEGA annotation of GRCm38   4095 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:12890  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: metabotropic glutamate receptor-like protein
Gene Tree: Tas1r3

Human homologs

Human Homolog		TAS1R3, taste receptor, type 1, member 3
NCBI Gene ID		83756
neXtProt AC		NX_Q7RTX0
Human Synonyms		T1R3
Human Chr (Location)		1p36.33; chr1:1266726-1269844 (+)  GRCh37.p10

Alleles and phenotypes

All alleles(7) : Targeted(5) Other(2)
 

Mutation of this locus affects taste perception. Complete inactivation results in diminished behavioral and nervous repsonses to both sweet and umami tastants.

 

Gene Ontology (GO) classifications

All GO classifications: (22 annotations)

Process	detection of chemical stimulus involved in sensory perception of sweet taste, G-protein coupled receptor signaling pathway, ...
Component	integral to membrane, integral to plasma membrane, ...
Function	G-protein coupled receptor activity, protein binding, ...

External Resources: FuncBase

Expression

Literature Summary: (2 records)
cDNA source data(4)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(9) Genomic(3) cDNA(4) Other(2)
Microarray probesets(2)

Other database links

VEGA Gene Model	OTTMUSG00000010892 (Evidence)
Ensembl Gene Model	ENSMUSG00000029072 (Evidence)
Entrez Gene	83771 (Evidence)
UniGene	358792
DFCI	TC1590735
DoTS	DT.94175600
NIA Mouse Gene Index	U025884
Consensus CDS Project	CCDS19046.1
International Mouse Knockout Project Status	Tas1r3

Sequences

Length	Strain/Species
genomic	OTTMUSG00000010892	VEGA Gene Model | MGI Sequence Detail	4095	C57BL/6J
transcript	OTTMUST00000025532	VEGA | MGI Sequence Detail	3523	Not Applicable
polypeptide	OTTMUSP00000011689	VEGA | MGI Sequence Detail	858	Not Applicable

All sequences(21) RefSeq(2) UniProt(1)

Polymorphisms

SNPs(51 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR001828	Extracellular ligand-binding receptor
InterPro	IPR000337	GPCR, family 3
InterPro	IPR017979	GPCR, family 3, conserved site
InterPro	IPR017978	GPCR, family 3, C-terminal
InterPro	IPR011500	GPCR, family 3, nine cysteines domain
Protein Ontology	PR:000016062	taste receptor type 1 member 3

References

(Earliest) J:5474 Fuller JL, Single-locus control of saccharin preference in mice. J Hered. 1974 Jan-Feb;65(1):33-6
(Latest) J:190485 Treesukosol Y, et al., Orosensory detection of sucrose, maltose, and glucose is severely impaired in mice lacking T1R2 or T1R3, but Polycose sensitivity remains relatively normal. Am J Physiol Regul Integr Comp Physiol. 2012 Jul 15;303(2):R218-35
All references(71)

Other accession IDs

MGD-MRK-14284, MGI:98226