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Tas1r2
Gene Detail
 Symbol
Name
ID
Tas1r2
taste receptor, type 1, member 2
MGI:1933546
Synonyms Gpr71, T1r2, TR2
Feature Type protein coding gene
Genetic Map
Chromosome 4
70.82 cM
Detailed Genetic Map ± 1 cM


Mapping data(4)
Sequence Map
Chr4:139653538-139670280 bp, + strand
From VEGA annotation of GRCm38

  16743 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:75323  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog

Protein SuperFamily: metabotropic glutamate receptor-like protein
Gene Tree: Tas1r2

Human
homologs
Human Homolog TAS1R2, taste receptor, type 1, member 2
NCBI Gene ID 80834
neXtProt AC  NX_Q8TE23
Human Synonyms  GPR71, T1R2, TR2
Human Chr (Location)  1p36.13; chr1:18839599-18859661 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(4) : Targeted(4)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous mutant mice show diminished behavioral and nervous responses to sweet tastants. Response to umami tastants is unimpaired.
 
Interactions
Tas1r2 interacts with 73 markers (Mir29b-2, Mir33, Mir34a, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (20 annotations)
Process detection of chemical stimulus involved in sensory perception of sweet taste, G-protein coupled receptor signaling pathway, ...
Component integral component of membrane, membrane, ...
Function G-protein coupled receptor activity, protein binding, ...
External Resources: FuncBase
Expression
Literature Summary: (1 records)
cDNA source data(1)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(3) Genomic(2) cDNA(1)
Microarray probesets(2)
Other database
links
VEGA Gene ModelOTTMUSG00000010062 (Evidence)
Ensembl Gene ModelENSMUSG00000028738 (Evidence)
Entrez Gene83770 (Evidence)
UniGene190612
DFCITC1595589
DoTSDT.94156587
NIA Mouse Gene IndexU005020
Consensus CDS ProjectCCDS18849.1
International Mouse Knockout Project StatusTas1r2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000010062 VEGA Gene Model | MGI Sequence Detail 16743 C57BL/6J ±  kb
transcript OTTMUST00000023392 VEGA | MGI Sequence Detail 3047 Not Applicable 
polypeptide OTTMUSP00000010693 VEGA | MGI Sequence Detail 843 Not Applicable 

For the selected sequences
All sequences(23) RefSeq(2) UniProt(3)
Polymorphisms SNPs within 2kb(268 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001828 Extracellular ligand-binding receptor
InterPro IPR000337 GPCR, family 3
InterPro IPR017979 GPCR, family 3, conserved site
InterPro IPR017978 GPCR, family 3, C-terminal
InterPro IPR011500 GPCR, family 3, nine cysteines domain
Protein Ontology PR:000016061 taste receptor type 1 member 2
References (Earliest) J:53048 Hoon MA, et al., Putative mammalian taste receptors: a class of taste-specific GPCRs with distinct topographic selectivity. Cell. 1999 Feb 19;96(4):541-51
(Latest) J:205002 Simon BR, et al., Artificial sweeteners stimulate adipogenesis and suppress lipolysis independently of sweet taste receptors. J Biol Chem. 2013 Nov 8;288(45):32475-89
All references(42)
Other
accession IDs
MGI:1340027

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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Funding Information
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last database update
07/23/2014
MGI 5.19
The Jackson Laboratory