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Tas1r2 Gene Detail
Summary
  • Symbol
    Tas1r2
  • Name
    taste receptor, type 1, member 2
  • Synonyms
    Gpr71, T1r2, TR2
  • Feature Type
    protein coding gene
  • IDs
    MGI:1933546
    NCBI Gene: 83770
  • Gene Overview
    MyGene.info: TAS1R2
Location & Maps
more
  • Sequence Map
    Chr4:139653538-139670280 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      16743 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 4, 70.82 cM
  • Mapping Data
    4 experiments
Homology
more
  • Human Ortholog
    TAS1R2, taste 1 receptor member 2
  • Vertebrate Orthologs
    7
  • Human Ortholog
    TAS1R2, taste 1 receptor member 2
    Orthology source: HomoloGene
  • Synonyms
    GPR71, T1R2, TR2
  • Links
    NCBI Gene ID: 80834
    neXtProt AC: NX_Q8TE23

  • Chr Location
    1p36.13; chr1:18839599-18859661 (-)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    2 phenotypes from 2 alleles in 2 genetic backgrounds
    2 phenotypes from multigenic genotypes
    16 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    7
  • Chemically induced (other)
    2
  • Targeted
    5
  • Genomic Mutations
    3 involving Tas1r2
  • Incidental Mutations
Homozygous mutant mice show diminished behavioral and nervous responses to sweet tastants. Response to umami tastants is unimpaired.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000010062 VEGA Gene Model | MGI Sequence Detail 16743 C57BL/6J ±  kb
transcript OTTMUST00000023392 VEGA | MGI Sequence Detail 3047 Not Applicable  
polypeptide OTTMUSP00000010693 VEGA | MGI Sequence Detail 843 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    268 from dbSNP Build 142
Protein
Information
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  • UniProt
    3 Sequences
  • Protein Ontology
    PR:000016061 taste receptor type 1 member 2
  • InterPro Domains
    IPR000337 GPCR, family 3
    IPR017979 GPCR, family 3, conserved site
    IPR017978 GPCR family 3, C-terminal
    IPR011500 GPCR, family 3, nine cysteines domain
    IPR028082 Periplasmic binding protein-like I
    IPR001828 Receptor, ligand binding region
Molecular
Reagents
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  • All nucleic 3
    Genomic 2
    cDNA 1

    Microarray probesets 2
Other
Accession IDs
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MGI:1340027
References
more
  • Summaries
    All 42
    Developmental Gene Expression 2
    Gene Ontology 5
    Phenotypes 16
  • Earliest
    J:53048 Hoon MA, et al., Putative mammalian taste receptors: a class of taste-specific GPCRs with distinct topographic selectivity. Cell. 1999 Feb 19;96(4):541-51
  • Latest
    J:219031 Shimizu M, et al., Distinct human and mouse membrane trafficking systems for sweet taste receptors T1r2 and T1r3. PLoS One. 2014;9(7):e100425

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
06/22/2016
MGI 6.04
The Jackson Laboratory