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Tas1r2
Gene Detail
Symbol

Name
ID
Tas1r2
taste receptor, type 1, member 2
MGI:1933546
Synonyms
Gpr71, T1r2, TR2
Feature Type
protein coding gene
Genetic Map
Chromosome 4
70.82 cM
Detailed Genetic Map ± 1 cM


Mapping data(4)
Sequence Map
Chr4:139653538-139670280 bp, + strand
From VEGA annotation of GRCm38

  16743 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:75323  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog

HCOP human homology predictions: TAS1R2
Protein SuperFamily: metabotropic glutamate receptor-like protein
Gene Tree: Tas1r2

Human
homologs
TAS1R2, taste receptor, type 1, member 2
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 80834
neXtProt AC: NX_Q8TE23

Human Synonyms: GPR71, T1R2, TR2

Human Chr (Location): 1p36.13; chr1:18839599-18859661 (-)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(5) : Targeted(5)
Genomic Mutations involving Tas1r2 (1)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous mutant mice show diminished behavioral and nervous responses to sweet tastants. Response to umami tastants is unimpaired.
 
Interactions
Tas1r2 interacts with 73 markers (Mir29b-2, Mir33, Mir34a, ...)
Gene Ontology
(GO)
classifications
Expression
Literature Summary: (2 records)
cDNA source data(1)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: ZFIN tas1r2.1, tas1r2.2    NEW 
Molecular
reagents
All nucleic(3) Genomic(2) cDNA(1)
Microarray probesets(2)
Other database
links
VEGA Gene Model OTTMUSG00000010062 (Evidence)
Ensembl Gene Model ENSMUSG00000028738 (Evidence)
Entrez Gene 83770 (Evidence)
UniGene 190612
DFCI TC1595589
DoTS DT.94156587
NIA Mouse Gene Index U005020
Consensus CDS Project CCDS18849.1
International Mouse Phenotyping Consortium Status Tas1r2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000010062 VEGA Gene Model | MGI Sequence Detail 16743 C57BL/6J ±  kb
transcript OTTMUST00000023392 VEGA | MGI Sequence Detail 3047 Not Applicable 
polypeptide OTTMUSP00000010693 VEGA | MGI Sequence Detail 843 Not Applicable 

For the selected sequences
All sequences(23) RefSeq(2) UniProt(3)
Polymorphisms
SNPs within 2kb(268 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001828 Extracellular ligand-binding receptor
InterPro IPR000337 GPCR, family 3
InterPro IPR017979 GPCR, family 3, conserved site
InterPro IPR017978 GPCR, family 3, C-terminal
InterPro IPR011500 GPCR, family 3, nine cysteines domain
Protein Ontology PR:000016061 taste receptor type 1 member 2
References
(Earliest) J:53048 Hoon MA, et al., Putative mammalian taste receptors: a class of taste-specific GPCRs with distinct topographic selectivity. Cell. 1999 Feb 19;96(4):541-51
(Latest) J:217303 Koudelka J, et al., Genetic dissection of TrkB activated signalling pathways required for specific aspects of the taste system. Neural Dev. 2014;9:21
All references(44)
Other
accession IDs
MGI:1340027

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
06/23/2015
MGI 5.22
The Jackson Laboratory