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Srrt
Gene Detail
Symbol

Name
ID
Srrt
serrate RNA effector molecule homolog (Arabidopsis)
MGI:1933527
Synonyms
2810019G02Rik, Ars2, Asr2
Feature Type
protein coding gene
Genetic Map
Chromosome 5
76.33 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr5:137295704-137307674 bp, - strand
From Ensembl annotation of GRCm38

  11971 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:9298  Vertebrate Homology Class
1 human; 1 mouse; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog

HCOP human homology predictions: SRRT
Gene Tree: Srrt

Human
homologs
SRRT, serrate, RNA effector molecule
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 51593
neXtProt AC: NX_Q9BXP5

Human Synonyms: ARS2, ASR2, serrate

Human Chr (Location): 7q21; chr7:100874971-100888664 (+)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(41) : Gene trapped(38) Targeted(3)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Mice homozygous for a null allele display embryonic lethality before somite formation, increased apoptosis, and when cultured most fail to hatch from the zona pellucida.
 
Interactions
Srrt interacts with 30 markers (Mir17, Mir20a, Mir20b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (14 annotations)
Process cell proliferation, gene silencing by RNA, ...
Component cytoplasm, nucleoplasm, ...
Function DNA binding, poly(A) RNA binding, ...
External Resources: FuncBase
Expression
Literature Summary: (2 records)
Data Summary: Results (34)    Tissues (14)    Images (1)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 4
Northern blot 16
RT-PCR 14
cDNA source data(163)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase srrt    NEW 
Molecular
reagents
All nucleic(168) cDNA(163) Primer pair(3) Other(2)
Microarray probesets(2)
Other database
links
Ensembl Gene Model ENSMUSG00000037364 (Evidence)
Entrez Gene 83701 (Evidence)
UniGene 387734
DFCI TC1575817, TC1608772
DoTS DT.94269603, DT.97409831
NIA Mouse Gene Index U026841
Consensus CDS Project CCDS39331.1, CCDS80439.1, CCDS80440.1
International Mouse Phenotyping Consortium Status Srrt
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000037364 Ensembl Gene Model | MGI Sequence Detail 11971 C57BL/6J ±  kb
transcript ENSMUST00000040873 Ensembl | MGI Sequence Detail 3024 Not Applicable 
polypeptide ENSMUSP00000043123 Ensembl | MGI Sequence Detail 875 Not Applicable 

For the selected sequences
All sequences(43) RefSeq(16) UniProt(7)
Polymorphisms
SNPs within 2kb(68 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR007042 Arsenite-resistance protein 2
InterPro IPR021933 Protein of unknown function DUF3546
Protein Ontology PR:000015641 serrate RNA effector molecule
References
(Earliest) J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
(Latest) J:192528 Olejniczak SH, et al., Long-lived microRNA-Argonaute complexes in quiescent cells can be activated to regulate mitogenic responses. Proc Natl Acad Sci U S A. 2013 Jan 2;110(1):157-62
All references(35)
Other
accession IDs
MGI:1922076

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/25/2015
MGI 6.0
The Jackson Laboratory