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Srrt Gene Detail
Summary
  • Symbol
    Srrt
  • Name
    serrate RNA effector molecule homolog (Arabidopsis)
  • Synonyms
    2810019G02Rik, Ars2, Asr2
  • Feature Type
    protein coding gene
  • IDs
    MGI:1933527
    NCBI Gene: 83701
  • Gene Overview
    MyGene.info: SRRT
  • Alliance
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr5:137295704-137307674 bp, - strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 5, 76.33 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    68 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1933527
protein coding gene Chr5:137295704-137307714 (-)
129S1/SvImJ MGP_129S1SvImJ_G0030222
protein coding gene Chr5:142027249-142039241 (-)
A/J MGP_AJ_G0030190
protein coding gene Chr5:135847580-135859558 (-)
AKR/J MGP_AKRJ_G0030123
protein coding gene Chr5:140251503-140263467 (-)
BALB/cJ MGP_BALBcJ_G0030200
protein coding gene Chr5:137217990-137230001 (-)
C3H/HeJ MGP_C3HHeJ_G0029916
protein coding gene Chr5:140905496-140917474 (-)
C57BL/6NJ MGP_C57BL6NJ_G0030652
protein coding gene Chr5:147291489-147303457 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0027870
protein coding gene Chr5:130101195-130113474 (-)
CAST/EiJ MGP_CASTEiJ_G0029326
protein coding gene Chr5:140306116-140318075 (-)
CBA/J MGP_CBAJ_G0029886
protein coding gene Chr5:153130115-153142110 (-)
DBA/2J MGP_DBA2J_G0030037
protein coding gene Chr5:135755997-135767981 (-)
FVB/NJ MGP_FVBNJ_G0029992
protein coding gene Chr5:134945975-134957953 (-)
LP/J MGP_LPJ_G0030126
protein coding gene Chr5:142491435-142503452 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0030024
protein coding gene Chr5:155974587-155987929 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0030693
protein coding gene Chr5:140101002-140118706 (-)
PWK/PhJ MGP_PWKPhJ_G0029039
protein coding gene Chr5:134834363-134846340 (-)
SPRET/EiJ MGP_SPRETEiJ_G0028875
protein coding gene Chr5:137663669-137675634 (-)
WSB/EiJ MGP_WSBEiJ_G0029399
protein coding gene Chr5:140835861-140847825 (-)



Homology
more
  • Human Ortholog
    SRRT, serrate, RNA effector molecule
  • Vertebrate Orthologs
    6
  • Human Ortholog
    SRRT, serrate, RNA effector molecule
    Orthology source: HomoloGene, HGNC
  • Synonyms
    ARS2, ASR2, serrate
  • Links
    NCBI Gene ID: 51593
    neXtProt AC: NX_Q9BXP5
    UniProt: Q9BXP5

  • Chr Location
    7q22.1; chr7:100874971-100888664 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    7 phenotypes from 3 alleles in 2 genetic backgrounds
    10 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele display embryonic lethality before somite formation, increased apoptosis, and when cultured most fail to hatch from the zona pellucida.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000037364 Ensembl Gene Model | MGI Sequence Detail 11971 C57BL/6J ±  kb
    transcript ENSMUST00000040873 Ensembl | MGI Sequence Detail 3024 Not Applicable  
    polypeptide ENSMUSP00000043123 Ensembl | MGI Sequence Detail 875 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 169
      cDNA 164
      Primer pair 3
      Other 2

      Microarray probesets 2
    Other
    Accession IDs
    less
    MGI:1922076
    References
    more
    • Summaries
      All 36
      Developmental Gene Expression 2
      Gene Ontology 5
      Phenotypes 10
    • Earliest
      J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
    • Latest
      J:238763 Choo HJ, et al., Karyopherin Alpha 1 Regulates Satellite Cell Proliferation and Survival by Modulating Nuclear Import. Stem Cells. 2016 Nov;34(11):2784-2797

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
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    last database update
    11/06/2018
    MGI 6.13
    The Jackson Laboratory