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Srrt
Gene Detail
 Symbol
Name
ID
Srrt
serrate RNA effector molecule homolog (Arabidopsis)
MGI:1933527
Synonyms 2810019G02Rik, Ars2, Asr2
Feature Type protein coding gene
Genetic Map
Chromosome 5
76.33 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr5:137295704-137307674 bp, - strand
From NCBI annotation of GRCm38

  11971 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:9298  Vertebrate Homology Class
1 human; 1 mouse; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog

Gene Tree: Srrt

Human
homologs
Human Homolog SRRT, serrate, RNA effector molecule
NCBI Gene ID 51593
neXtProt AC  NX_Q9BXP5
Human Synonyms  ARS2, ASR2, serrate
Human Chr (Location)  7q21; chr7:100875079-100888664 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(41) : Gene trapped(38) Targeted(3)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a null allele display embryonic lethality before somite formation, increased apoptosis, and when cultured most fail to hatch from the zona pellucida.
 
Interactions
Srrt interacts with 30 markers (Mir17, Mir20a, Mir20b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (13 annotations)
Process cell proliferation, gene silencing by RNA, ...
Component cytoplasm, nucleoplasm, ...
Function DNA binding, poly(A) RNA binding, ...
External Resources: FuncBase
Expression
Literature Summary: (2 records)
Data Summary: Results (32)    Tissues (13)   
Theiler Stages: 4, 10, 18, 23, 25, 28
Assay TypeResults
Immunohistochemistry 4
Northern blot 16
RT-PCR 12
cDNA source data(163)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(167) cDNA(163) Primer pair(2) Other(2)
Microarray probesets(2)
Other database
links
Ensembl Gene ModelENSMUSG00000037364 (Evidence)
Entrez Gene83701 (Evidence)
UniGene387734
DFCITC1575817, TC1608772
DoTSDT.94269603, DT.97409831
NIA Mouse Gene IndexU026841
Consensus CDS ProjectCCDS39331.1
International Mouse Knockout Project StatusSrrt
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 83701 NCBI Gene Model | MGI Sequence Detail 11971 C57BL/6J ±  kb
transcript NM_031405 RefSeq | MGI Sequence Detail 3039 C57BL/6 
polypeptide Q99MR6 UniProt | EBI | MGI Sequence Detail 875 Not Applicable 

For the selected sequences
All sequences(35) RefSeq(14) UniProt(1)
Polymorphisms SNPs within 2kb(68 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR007042 Arsenite-resistance protein 2
InterPro IPR021933 Protein of unknown function DUF3546
Protein Ontology PR:000015641 serrate RNA effector molecule
Graphical View of Protein Domain Structure
References (Earliest) J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
(Latest) J:192528 Olejniczak SH, et al., Long-lived microRNA-Argonaute complexes in quiescent cells can be activated to regulate mitogenic responses. Proc Natl Acad Sci U S A. 2013 Jan 2;110(1):157-62
All references(36)
Other
accession IDs
MGI:1922076

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
09/23/2014
MGI 5.19
The Jackson Laboratory