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Akr1c6 Gene Detail
Summary
  • Symbol
    Akr1c6
  • Name
    aldo-keto reductase family 1, member C6
  • Synonyms
    3alpha-HSD, Akr1c1, estradiol 17-beta-dehydrogenase (A-specific), Hsd17b5
  • Feature Type
    protein coding gene
  • IDs
    MGI:1933427
    NCBI Gene: 83702
Location & Maps
more
  • Sequence Map
    Chr13:4434306-4457530 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      23225 bp   ±  kb flank

  • Genome Browsers
Homology
more
  • Human Ortholog
    AKR1C4, aldo-keto reductase family 1, member C4
  • Vertebrate Orthologs
    5
  • Human Ortholog
    AKR1C4, aldo-keto reductase family 1, member C4
    Orthology source: HomoloGene
  • Synonyms
    3-alpha-HSD, C11, CDR, CHDR, DD4, DD-4, HAKRA
  • Links
    NCBI Gene ID: 1109
    neXtProt AC: NX_P17516

  • Chr Location
    10p15.1; chr10:5196809-5220633 (+)  GRCh38.p2

Human Diseases
more
  • Diseases
    1 with human AKR1C4 associations

Human Disease Mouse Models
       46,xy Sex Reversal 8; SRXY8   OMIM: 614279
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    2 phenotype references
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000027687 VEGA Gene Model | MGI Sequence Detail 23225 C57BL/6J ±  kb
transcript OTTMUST00000068500 VEGA | MGI Sequence Detail 1396 Not Applicable  
polypeptide OTTMUSP00000034654 VEGA | MGI Sequence Detail 323 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    250 from dbSNP Build 137
Protein
Information
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  • UniProt
    3 Sequences
  • Protein Ontology
    PR:000004562 estradiol 17 beta-dehydrogenase 5
  • EC
  • InterPro Domains
    IPR020471 Aldo/keto reductase
    IPR018170 Aldo/keto reductase, conserved site
    IPR001395 Aldo/keto reductase/potassium channel subunit beta
    IPR023210 NADP-dependent oxidoreductase domain
Molecular
Reagents
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  • All nucleic 117
    Genomic 1
    cDNA 115
    Primer pair 1

    Microarray probesets 3
Other
Accession IDs
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MGI:1096387, MGI:1931562
References
more
  • Summaries
    All 44
    Developmental Gene Expression 11
    Gene Ontology 7
    Phenotypes 2
  • Earliest
    J:25103 Deyashiki Y, et al., Molecular cloning and characterization of mouse estradiol 17 beta-dehydrogenase (A-specific), a member of the aldoketoreductase family. J Biol Chem. 1995 May 5;270(18):10461-7
  • Latest
    J:222168 Huang CC, et al., A Novel Population of Inner Cortical Cells in the Adrenal Gland That Displays Sexually Dimorphic Expression of Thyroid Hormone Receptor-beta1. Endocrinology. 2015 Jun;156(6):2338-48

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
02/02/2016
MGI 6.02
The Jackson Laboratory