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Akr1c6
Gene Detail
Symbol

Name
ID
Akr1c6
aldo-keto reductase family 1, member C6
MGI:1933427
Synonyms
3alpha-HSD, Akr1c1, estradiol 17-beta-dehydrogenase (A-specific), Hsd17b5
Feature Type
protein coding gene
Genetic Map
Chromosome 13
2.48 cM, cytoband A2
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr13:4434306-4457530 bp, + strand
From VEGA annotation of GRCm38

  23225 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:84695  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 western clawed frog

HCOP human homology predictions: AKR1C4
Protein SuperFamily: AKR
Gene Tree: Akr1c6

Human
homologs
AKR1C4, aldo-keto reductase family 1, member C4
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 1109
neXtProt AC: NX_P17516

Human Synonyms: 3-alpha-HSD, C11, CDR, CHDR, DD4, DD-4, HAKRA

Human Chr (Location): 10p15.1; chr10:5196809-5220633 (+)  GRCh38.p2

Disease Associations: (1) Diseases Associated with Human AKR1C4

Mutations,
alleles, and
phenotypes
All mutations/alleles(1) : Targeted(1)
Incidental mutations (data from Mutagenetix , APF )
Interactions
Akr1c6 interacts with 105 markers (Mir19a, Mir19b-1, Mir19b-2, ...)
Expression
Literature Summary: (10 records)
Data Summary: Results (299)    Tissues (216)    Images (28)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 291
RT-PCR 8
cDNA source data(115)
Other mouse links: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(117) Genomic(1) cDNA(115) Primer pair(1)
Microarray probesets(3)
Other database
links
VEGA Gene Model OTTMUSG00000027687 (Evidence)
Ensembl Gene Model ENSMUSG00000021210 (Evidence)
Entrez Gene 83702 (Evidence)
UniGene 196666
DFCI TC1576542
DoTS DT.94388175, DT.537294
NIA Mouse Gene Index U014513
EC 1.1.1.-
Consensus CDS Project CCDS26223.1
International Mouse Phenotyping Consortium Status Akr1c6
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000027687 VEGA Gene Model | MGI Sequence Detail 23225 C57BL/6J ±  kb
transcript OTTMUST00000068500 VEGA | MGI Sequence Detail 1396 Not Applicable 
polypeptide OTTMUSP00000034654 VEGA | MGI Sequence Detail 323 Not Applicable 

For the selected sequences
All sequences(35) RefSeq(4) UniProt(3)
Polymorphisms
SNPs within 2kb(250 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001395 Aldo/keto reductase
InterPro IPR018170 Aldo/keto reductase, conserved site
InterPro IPR020471 Aldo/keto reductase subgroup
InterPro IPR023210 NADP-dependent oxidoreductase domain
Protein Ontology PR:000004562 estradiol 17 beta-dehydrogenase 5
References
(Earliest) J:25103 Deyashiki Y, et al., Molecular cloning and characterization of mouse estradiol 17 beta-dehydrogenase (A-specific), a member of the aldoketoreductase family. J Biol Chem. 1995 May 5;270(18):10461-7
(Latest) J:204486 Zheng S, et al., A broadly applicable high-throughput screening strategy identifies new regulators of Dlg4 (Psd-95) alternative splicing. Genome Res. 2013 Jun;23(6):998-1007
All references(46)
Other
accession IDs
MGI:1096387, MGI:1931562

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
06/23/2015
MGI 5.22
The Jackson Laboratory