About   Help   FAQ
Akr1c6
Gene Detail
 Symbol
Name
ID
Akr1c6
aldo-keto reductase family 1, member C6
MGI:1933427
Synonyms 3alpha-HSD, Akr1c1, estradiol 17-beta-dehydrogenase (A-specific), Hsd17b5
Feature Type protein coding gene
Genetic Map
Chromosome 13
2.48 cM, cytoband A2
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr13:4434306-4457530 bp, + strand
From VEGA annotation of GRCm38

  23225 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:84695  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 western clawed frog

Protein SuperFamily: AKR
Gene Tree: Akr1c6

Human
homologs
Human Homolog AKR1C4, aldo-keto reductase family 1, member C4
NCBI Gene ID 1109
neXtProt AC  NX_P17516
Human Synonyms  3-alpha-HSD, C11, CDR, CHDR, DD4, DD-4, HAKRA
Human Chr (Location)  10p15.1; chr10:5196835-5218947 (+)  GRCh38
Disease Associations  (1) Diseases Associated with Human AKR1C4
Mutations,
alleles, and
phenotypes
All mutations/alleles(1) : Targeted(1)
Incidental mutations (data from Mutagenetix , APF )
Interactions
Akr1c6 interacts with 105 markers (Mir19a, Mir19b-1, Mir19b-2, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (46 annotations)
Process cellular response to jasmonic acid stimulus, daunorubicin metabolic process, ...
Component cytoplasm, extracellular vesicular exosome, ...
Function 17-alpha,20-alpha-dihydroxypregn-4-en-3-one dehydrogenase activity, 2-hydroxytetrahydrofuran dehydrogenase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (10 records)
Data Summary: Results (299)    Tissues (216)    Images (28)
Theiler Stages: 22, 23, 24, 25, 26, 28
Assay TypeResults
RNA in situ 291
RT-PCR 8
cDNA source data(115)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(117) Genomic(1) cDNA(115) Primer pair(1)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000027687 (Evidence)
Ensembl Gene ModelENSMUSG00000021210 (Evidence)
Entrez Gene83702 (Evidence)
UniGene196666
DFCITC1576542
DoTSDT.537294, DT.94388175
NIA Mouse Gene IndexU014513
EC1.1.1.-
Consensus CDS ProjectCCDS26223.1
International Mouse Knockout Project StatusAkr1c6
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000027687 VEGA Gene Model | MGI Sequence Detail 23225 C57BL/6J ±  kb
transcript OTTMUST00000068500 VEGA | MGI Sequence Detail 1396 Not Applicable 
polypeptide OTTMUSP00000034654 VEGA | MGI Sequence Detail 323 Not Applicable 

For the selected sequences
All sequences(35) RefSeq(4) UniProt(3)
Polymorphisms SNPs within 2kb(250 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001395 Aldo/keto reductase
InterPro IPR018170 Aldo/keto reductase, conserved site
InterPro IPR020471 Aldo/keto reductase subgroup
InterPro IPR023210 NADP-dependent oxidoreductase domain
Protein Ontology PR:000004562 estradiol 17 beta-dehydrogenase 5
References (Earliest) J:25103 Deyashiki Y, et al., Molecular cloning and characterization of mouse estradiol 17 beta-dehydrogenase (A-specific), a member of the aldoketoreductase family. J Biol Chem. 1995 May 5;270(18):10461-7
(Latest) J:204470 Inagawa M, et al., Histone H3 lysine 9 methyltransferases, G9a and GLP are essential for cardiac morphogenesis. Mech Dev. 2013 Nov-Dec;130(11-12):519-31
All references(47)
Other
accession IDs
MGI:1096387, MGI:1931562

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
09/23/2014
MGI 5.19
The Jackson Laboratory