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Hcar2 Gene Detail
Summary
  • Symbol
    Hcar2
  • Name
    hydroxycarboxylic acid receptor 2
  • Synonyms
    Gpr109a, Gpr109b, HM74, Niacr1, Pumag, PUMA-G
  • Feature Type
    protein coding gene
  • IDs
    MGI:1933383
    NCBI Gene: 80885
Location & Maps
more
  • Sequence Map
    Chr5:123863570-123865499 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      1930 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 5, 63.24 cM, cytoband F
  • Mapping Data
    1 experiment
Homology
more
  • Human Ortholog
    HCAR2, hydroxycarboxylic acid receptor 2
  • Vertebrate Orthologs
    4
  • Human Ortholog
    HCAR2, hydroxycarboxylic acid receptor 2
    Orthology source: HomoloGene, HGNC
  • Synonyms
    GPR109A, HCA2, HM74a, HM74b, NIACR1, Puma-g, PUMAG
  • Links
    NCBI Gene ID: 338442
    neXtProt AC: NX_Q8TDS4

  • Chr Location
    12q24.31; chr12:122701293-122703357 (-)  GRCh38.p2

  • Human Ortholog
    HCAR3, hydroxycarboxylic acid receptor 3
    Orthology source: HGNC
  • Synonyms
    GPR109B, HCA3, HM74, Puma-g, PUMAG
  • Links
    NCBI Gene ID: 8843
    neXtProt AC: NX_P49019

  • Chr Location
    12q24.31; chr12:122714756-122716892 (-)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    21 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    4
  • Chemically induced (other)
    1
  • Radiation induced
    1
  • Targeted
    2
  • Genomic Mutations
    2 involving Hcar2
  • Incidental Mutations
    APF , CvDC
Mice homozygous for targeted mutations that inactivate the gene showed impaired reductions of free fatty acid (FFA) and triglyceride plasma levels in response to nicotinic acid.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000054742 VEGA Gene Model | MGI Sequence Detail 1930 C57BL/6J ±  kb
transcript OTTMUST00000135690 VEGA | MGI Sequence Detail 1930 Not Applicable  
polypeptide OTTMUSP00000071771 VEGA | MGI Sequence Detail 360 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    24 from dbSNP Build 142
Protein
Information
less
  • UniProt
    2 Sequences
  • Protein Ontology
    PR:000001629 hydroxycarboxylic acid receptor 2
  • InterPro Domains
    IPR017452 GPCR, rhodopsin-like, 7TM
    IPR000276 G protein-coupled receptor, rhodopsin-like
    IPR028017 Hydroxycarboxylic acid receptor 2/3
Molecular
Reagents
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  • All nucleic 8
    Genomic 1
    cDNA 6
    Primer pair 1

    Microarray probesets 2
References
more
  • Summaries
    All 41
    Developmental Gene Expression 2
    Gene Ontology 5
    Phenotypes 21
  • Earliest
    J:73352 Schaub A, et al., PUMA-G, an IFN-gamma-inducible gene in macrophages is a novel member of the seven transmembrane spanning receptor superfamily. Eur J Immunol. 2001 Dec;31(12):3714-25
  • Latest
    J:227935 Youm YH, et al., The ketone metabolite beta-hydroxybutyrate blocks NLRP3 inflammasome-mediated inflammatory disease. Nat Med. 2015 Mar;21(3):263-9

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
09/27/2016
MGI 6.05
The Jackson Laboratory