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Sytl1 Gene Detail
Summary
  • Symbol
    Sytl1
  • Name
    synaptotagmin-like 1
  • Synonyms
    MGC:7008, PSGL-1, Slp1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1933365
    NCBI Gene: 269589
  • Gene Overview
    MyGene.info: SYTL1
  • Alliance
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr4:133253090-133263087 bp, - strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 4, 66.25 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    170 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1933365
protein coding gene Chr4:133253090-133263113 (-)
129S1/SvImJ MGP_129S1SvImJ_G0028890
protein coding gene Chr4:135487652-135498984 (-)
A/J MGP_AJ_G0028849
protein coding gene Chr4:129822759-129832803 (-)
AKR/J MGP_AKRJ_G0028802
protein coding gene Chr4:133505176-133515220 (-)
BALB/cJ MGP_BALBcJ_G0028872
protein coding gene Chr4:130443697-130453752 (-)
C3H/HeJ MGP_C3HHeJ_G0028586
protein coding gene Chr4:133756789-133766833 (-)
C57BL/6NJ MGP_C57BL6NJ_G0029314
protein coding gene Chr4:140358903-140368926 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0026585
protein coding gene Chr4:122903670-122913242 (-)
CAST/EiJ MGP_CASTEiJ_G0028019
protein coding gene Chr4:131865779-131875786 (-)
CBA/J MGP_CBAJ_G0028552
protein coding gene Chr4:144013480-144023524 (-)
DBA/2J MGP_DBA2J_G0028701
protein coding gene Chr4:130243144-130253214 (-)
FVB/NJ MGP_FVBNJ_G0028668
protein coding gene Chr4:129115905-129128086 (-)
LP/J MGP_LPJ_G0028802
protein coding gene Chr4:135617125-135627192 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0028694
protein coding gene Chr4:148540134-148550189 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0029352
protein coding gene Chr4:133924677-133934700 (-)
PWK/PhJ MGP_PWKPhJ_G0027740
protein coding gene Chr4:126953439-126963500 (-)
SPRET/EiJ MGP_SPRETEiJ_G0027566
protein coding gene Chr4:129768767-129778853 (-)
WSB/EiJ MGP_WSBEiJ_G0028099
protein coding gene Chr4:134098536-134108559 (-)



Homology
more
  • Human Ortholog
    SYTL1, synaptotagmin like 1
  • Vertebrate Orthologs
    10
  • Human Ortholog
    SYTL1, synaptotagmin like 1
    Orthology source: HomoloGene, HGNC
  • Synonyms
    JFC1, SLP1
  • Links
    NCBI Gene ID: 84958
    neXtProt AC: NX_Q8IYJ3
    UniProt: Q8IYJ3

  • Chr Location
    1p36.11; chr1:27341992-27353932 (+)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 12853
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: SYTL1
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    18 phenotypes from 3 alleles in 4 genetic backgrounds
    2 phenotypes from multigenic genotypes
    16 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele exhibit increased number of acinar zygomen granules in a fasted state that can be released by strong stimuli of the fed state.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 269589 NCBI Gene Model | MGI Sequence Detail 9998 C57BL/6J ±  kb
    transcript NM_031393 RefSeq | MGI Sequence Detail 1940 C57BL/6  
    polypeptide Q99N80 UniProt | EBI | MGI Sequence Detail 567 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 52
      cDNA 51
      Primer pair 1

      Microarray probesets 2
    References
    more
    • Summaries
      All 39
      Developmental Gene Expression 2
      Gene Ontology 8
      Phenotypes 16
    • Earliest
      J:68115 Fukuda M, et al., Synaptotagmin-like protein 1-3: a novel family of c-terminal-type tandem c2 proteins. Biochem Biophys Res Commun. 2001 Mar 16;281(5):1226-33
    • Latest
      J:239621 Kurz AR, et al., MST1-dependent vesicle trafficking regulates neutrophil transmigration through the vascular basement membrane. J Clin Invest. 2016 Nov 01;126(11):4125-4139

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    11/13/2018
    MGI 6.13
    The Jackson Laboratory