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Sytl1
Gene Detail
Symbol

Name
ID
Sytl1
synaptotagmin-like 1
MGI:1933365
Synonyms
MGC:7008, PSGL-1, Slp1
Feature Type
protein coding gene
Genetic Map
Chromosome 4
66.25 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr4:133253090-133263113 bp, - strand
From VEGA annotation of GRCm38

  10024 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:12853  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: SYTL1
Gene Tree: Sytl1

Human
homologs
SYTL1, synaptotagmin-like 1
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 84958
neXtProt AC: NX_Q8IYJ3

Human Synonyms: JFC1, SLP1

Human Chr (Location): 1p36.11; chr1:27341992-27353932 (+)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(5) : Gene trapped(1) Targeted(4)
Genomic Mutations involving Sytl1 (1)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a null allele exhibit increased number of acinar zygomen granules in a fasted state that can be released by strong stimuli of the fed state.
 
Interactions
Sytl1 interacts with 15 markers (Mir22, Mir30a, Mir30b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (22 annotations)
Process calcium ion-dependent exocytosis of neurotransmitter, exocytosis, ...
Component exocytic vesicle, extracellular exosome, ...
Function calcium-dependent phospholipid binding, calcium ion binding, ...
External Resources: FuncBase
Expression
Literature Summary: (2 records)
Data Summary: Results (12)    Tissues (12)    Tissue x Stage Matrix (view)
Assay TypeResults
RT-PCR 12
cDNA source data(50)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase sytl1    NEW 
Molecular
reagents
All nucleic(51) cDNA(50) Primer pair(1)
Microarray probesets(2)
Other database
links
VEGA Gene Model OTTMUSG00000010476 (Evidence)
Ensembl Gene Model ENSMUSG00000028860 (Evidence)
Entrez Gene 269589 (Evidence)
UniGene 25660
DFCI TC1582540, TC1585819
DoTS DT.101363229, DT.524390
NIA Mouse Gene Index U025614
Consensus CDS Project CCDS38902.1
International Mouse Phenotyping Consortium Status Sytl1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000010476 VEGA Gene Model | MGI Sequence Detail 10024 C57BL/6J ±  kb
transcript OTTMUST00000024399 VEGA | MGI Sequence Detail 1951 Not Applicable 
polypeptide OTTMUSP00000011227 VEGA | MGI Sequence Detail 568 Not Applicable 

For the selected sequences
All sequences(35) RefSeq(4) UniProt(4)
Polymorphisms
SNPs within 2kb(169 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR000008 C2 calcium-dependent membrane targeting
InterPro IPR010911 Rab-binding domain
InterPro IPR013083 Zinc finger, RING/FYVE/PHD-type
Protein Ontology PR:000015912 synaptotagmin-like protein 1
References
(Earliest) J:68115 Fukuda M, et al., Synaptotagmin-like protein 1-3: a novel family of c-terminal-type tandem c2 proteins. Biochem Biophys Res Commun. 2001 Mar 16;281(5):1226-33
(Latest) J:213427 Adissu HA, et al., Histopathology reveals correlative and unique phenotypes in a high-throughput mouse phenotyping screen. Dis Model Mech. 2014 May;7(5):515-24
All references(37)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/18/2015
MGI 6.0
The Jackson Laboratory