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Sytl1 Gene Detail
Summary
  • Symbol
    Sytl1
  • Name
    synaptotagmin-like 1
  • Synonyms
    MGC:7008, PSGL-1, Slp1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1933365
    NCBI Gene: 269589
  • Gene Overview
    MyGene.info: SYTL1
Location & Maps
more
  • Sequence Map
    Chr4:133253090-133263113 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      10024 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 4, 66.25 cM
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    SYTL1, synaptotagmin like 1
  • Vertebrate Orthologs
    10
  • Human Ortholog
    SYTL1, synaptotagmin like 1
    Orthology source: HomoloGene
  • Synonyms
    JFC1, SLP1
  • Links
    NCBI Gene ID: 84958
    neXtProt AC: NX_Q8IYJ3

  • Chr Location
    1p36.11; chr1:27341992-27353932 (+)  GRCh38.p2

  • HomoloGene
    Vertebrate Homology Class 12853
    1 human;1 mouse;1 rat;1 chimpanzee;1 rhesus macaque;1 cattle;1 dog;1 chicken;1 western clawed frog;1 zebrafish
  • HCOP
    human homology predictions: SYTL1
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    6 phenotypes from 3 alleles in 3 genetic backgrounds
    2 phenotypes from multigenic genotypes
    14 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    8
  • Chemically induced (other)
    2
  • Gene trapped
    1
  • Radiation induced
    1
  • Targeted
    4
  • Genomic Mutations
    4 involving Sytl1
  • Incidental Mutations
Mice homozygous for a null allele exhibit increased number of acinar zygomen granules in a fasted state that can be released by strong stimuli of the fed state.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000010476 VEGA Gene Model | MGI Sequence Detail 10024 C57BL/6J ±  kb
transcript OTTMUST00000024399 VEGA | MGI Sequence Detail 1951 Not Applicable  
polypeptide OTTMUSP00000011227 VEGA | MGI Sequence Detail 568 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    170 from dbSNP Build 142
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 51
    cDNA 50
    Primer pair 1

    Microarray probesets 2
References
more
  • Summaries
    All 33
    Developmental Gene Expression 2
    Gene Ontology 7
    Phenotypes 14
  • Earliest
    J:68115 Fukuda M, et al., Synaptotagmin-like protein 1-3: a novel family of c-terminal-type tandem c2 proteins. Biochem Biophys Res Commun. 2001 Mar 16;281(5):1226-33
  • Latest
    J:213427 Adissu HA, et al., Histopathology reveals correlative and unique phenotypes in a high-throughput mouse phenotyping screen. Dis Model Mech. 2014 May;7(5):515-24

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
08/17/2016
MGI 6.05
The Jackson Laboratory