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Trim8 Gene Detail
Summary
  • Symbol
    Trim8
  • Name
    tripartite motif-containing 8
  • Synonyms
    GERP, Rnf27
  • Feature Type
    protein coding gene
  • IDs
    MGI:1933302
    NCBI Gene: 93679
  • Alliance
  • Transcription Start Sites
    26 TSS
Location &
Maps
more
  • Sequence Map
    Chr19:46490087-46504894 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 19, 38.92 cM, cytoband D1
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    36 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1933302
protein coding gene Chr19:46490087-46505287 (+)
129S1/SvImJ MGP_129S1SvImJ_G0025210
protein coding gene Chr19:46199213-46232803 (+)
A/J MGP_AJ_G0025186
protein coding gene Chr19:43921423-43936197 (+)
AKR/J MGP_AKRJ_G0025155
protein coding gene Chr19:45345811-45360565 (+)
BALB/cJ MGP_BALBcJ_G0025181
protein coding gene Chr19:43978478-43993141 (+)
C3H/HeJ MGP_C3HHeJ_G0024941
protein coding gene Chr19:45516217-45531604 (+)
C57BL/6NJ MGP_C57BL6NJ_G0025624
protein coding gene Chr19:47344436-47359216 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0023038
protein coding gene Chr19:43163841-43179150 (+)
CAST/EiJ MGP_CASTEiJ_G0024406
protein coding gene Chr19:45323255-45338024 (+)
CBA/J MGP_CBAJ_G0024921
protein coding gene Chr19:49722421-49737169 (+)
DBA/2J MGP_DBA2J_G0025053
protein coding gene Chr19:43741044-43755650 (+)
FVB/NJ MGP_FVBNJ_G0025014
protein coding gene Chr19:43525996-43540779 (+)
LP/J MGP_LPJ_G0025139
protein coding gene Chr19:46110364-46126378 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0025045
protein coding gene Chr19:49058475-49073146 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0025682
protein coding gene Chr19:45459231-45473908 (+)
PWK/PhJ MGP_PWKPhJ_G0024155
protein coding gene Chr19:43694491-43709402 (+)
SPRET/EiJ MGP_SPRETEiJ_G0023959
protein coding gene Chr19:44106121-44120906 (+)
WSB/EiJ MGP_WSBEiJ_G0024476
protein coding gene Chr19:45607278-45623337 (+)



Homology
more
  • Human Ortholog
    TRIM8, tripartite motif containing 8
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    TRIM8, tripartite motif containing 8
  • Synonyms
    FSGSNEDS, GERP, RNF27
  • Links
    NCBI Gene ID: 81603
    neXtProt AC: NX_Q9BZR9
    UniProt: Q9BZR9

  • Chr Location
    10q24.32; chr10:102644484-102658319 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    29 phenotypes from 4 alleles in 4 genetic backgrounds
    10 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygous inactivation of this gene relieves hepatic ischemia/reperfusion injury and improves pressure overload-induced cardiac hypertrophy. Mice homozygous for a null allele show increased susceptibility to poly(I:C)-, LPS- and Salmonella typhimurium infection-induced death.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 93679 NCBI Gene Model | MGI Sequence Detail 14808 C57BL/6J ±  kb
    transcript NM_053100 RefSeq | MGI Sequence Detail 3262 C57BL/6  
    polypeptide Q99PJ2 UniProt | EBI | MGI Sequence Detail 551 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 14
      Genomic 2
      cDNA 12

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGI:2147440, MGI:2147763
    References
    more
    • Summaries
      All 42
      Developmental Gene Expression 4
      Gene Ontology 6
      Phenotypes 10
    • Earliest
      J:163150 Villalba M, et al., Isolation of three allergenic fractions of the major allergen from Olea europea pollen and N-terminal amino acid sequence. Biochem Biophys Res Commun. 1990 Oct 30;172(2):523-8
    • Latest
      J:303068 Tao Q, et al., Tripartite Motif 8 Deficiency Relieves Hepatic Ischaemia/reperfusion Injury via TAK1-dependent Signalling Pathways. Int J Biol Sci. 2019;15(8):1618-1629

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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    Funding Information
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    last database update
    09/22/2022
    MGI 6.21
    The Jackson Laboratory