Trim8 MGI Mouse Gene Detail - MGI:1933302 - tripartite motif-containing 8

Symbol

Trim8
Name

tripartite motif-containing 8
Synonyms

GERP, Rnf27

Feature Type

protein coding gene
IDs

MGI:1933302
NCBI Gene: 93679
Alliance

gene page
Transcription Start Sites

21 TSS

Sequence Map

Chr19:46490087-46504894 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 19, 38.92 cM, cytoband D1
Mapping Data

3 experiments

SNPs within 2kb

38 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1933302	protein coding gene	Chr19:46490087-46505287 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0025210	protein coding gene	Chr19:46199213-46232803 (+)
A/J	MGP_AJ_G0025186	protein coding gene	Chr19:43921423-43936197 (+)
AKR/J	MGP_AKRJ_G0025155	protein coding gene	Chr19:45345811-45360565 (+)
BALB/cJ	MGP_BALBcJ_G0025181	protein coding gene	Chr19:43978478-43993141 (+)
C3H/HeJ	MGP_C3HHeJ_G0024941	protein coding gene	Chr19:45516217-45531604 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0025624	protein coding gene	Chr19:47344436-47359216 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0023038	protein coding gene	Chr19:43163841-43179150 (+)
CAST/EiJ	MGP_CASTEiJ_G0024406	protein coding gene	Chr19:45323255-45338024 (+)
CBA/J	MGP_CBAJ_G0024921	protein coding gene	Chr19:49722421-49737169 (+)
DBA/2J	MGP_DBA2J_G0025053	protein coding gene	Chr19:43741044-43755650 (+)
FVB/NJ	MGP_FVBNJ_G0025014	protein coding gene	Chr19:43525996-43540779 (+)
LP/J	MGP_LPJ_G0025139	protein coding gene	Chr19:46110364-46126378 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0025045	protein coding gene	Chr19:49058475-49073146 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0025682	protein coding gene	Chr19:45459231-45473908 (+)
PWK/PhJ	MGP_PWKPhJ_G0024155	protein coding gene	Chr19:43694491-43709402 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0023959	protein coding gene	Chr19:44106121-44120906 (+)
WSB/EiJ	MGP_WSBEiJ_G0024476	protein coding gene	Chr19:45607278-45623337 (+)

Human Ortholog

TRIM8, tripartite motif containing 8

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

TRIM8, tripartite motif containing 8
Synonyms

FSGSNEDS, GERP, RNF27
Links

HGNC:15579

NCBI Gene ID: 81603

neXtProt AC: NX_Q9BZR9

UniProt: Q9BZR9
Chr Location

10q24.32; chr10:102642503-102658319 (+) GRCh38

MGI Vertebrate Homology

Trim8 stringent orthology
1 human;1 mouse;1 rat;2 zebrafish
HCOP

vertebrate homology predictions: TRIM8
Gene Tree

Trim8

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Phenotype Summary

29 phenotypes from 4 alleles in 4 genetic backgrounds
11 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

30
Endonuclease-mediated

6
Gene trapped

22
Targeted

1
Transgenic

1
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

25 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Homozygous inactivation of this gene relieves hepatic ischemia/reperfusion injury and improves pressure overload-induced cardiac hypertrophy. Mice homozygous for a null allele show increased susceptibility to poly(I:C)-, LPS- and Salmonella typhimurium infection-induced death.

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All GO Annotations

38
GO References

10

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

781
Tissues

63
cDNA Data

12
Literature Summary

5

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase trim8

ZFIN trim8b

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All Sequences

48
RefSeq

4
UniProt

1
CCDS

CCDS38009.1

Ensembl

ENSMUSG00000025034 (Evidence)
NCBI Gene

93679

			Length	Strain/Species	Flank
genomic	93679	NCBI Gene Model \| MGI Sequence Detail	14808	C57BL/6J	± kb
transcript	NM_001425026	RefSeq \| MGI Sequence Detail	3316	C57BL/6
polypeptide	Q99PJ2	UniProt \| EBI \| MGI Sequence Detail	551	Not Applicable

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UniProt

1 Sequence
Protein Ontology

PR:000030575 E3 ubiquitin-protein ligase TRIM8

(term hierarchy)
EC

2.3.2.27
InterPro Domains

IPR013083 Zinc finger, RING/FYVE/PHD-type

IPR001841 Zinc finger, RING-type

IPR017907 Zinc finger, RING-type, conserved site

IPR027370 Zinc finger, RING-type, eukaryotic

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All nucleic 15

Genomic 2

cDNA 12

Primer pair 1

Microarray probesets 5

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MGI:2147440, MGI:2147763

Summaries

All 48

Developmental Gene Expression 5

Gene Ontology 10

Phenotypes 11
Earliest

J:163150 Villalba M, et al., Isolation of three allergenic fractions of the major allergen from Olea europea pollen and N-terminal amino acid sequence. Biochem Biophys Res Commun. 1990 Oct 30;172(2):523-8
Latest

J:326541 Cyagen Biosciences Inc., Cyagen Biosciences Website. 2022;

TSS for Trim8:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr156762	Chr19:46489195-46489209 (+)	-885 bp
Tssr156763	Chr19:46489265-46489276 (+)	-816 bp
Tssr156764	Chr19:46489427-46489439 (+)	-654 bp
Tssr156765	Chr19:46489606-46489636 (+)	-466 bp
Tssr156766	Chr19:46489870-46489910 (+)	-197 bp
Tssr156767	Chr19:46490103-46490114 (+)	22 bp
Tssr156768	Chr19:46490124-46490146 (+)	48 bp
Tssr156769	Chr19:46490154-46490172 (+)	76 bp
Tssr156770	Chr19:46490177-46490212 (+)	108 bp
Tssr156771	Chr19:46490229-46490241 (+)	148 bp
Tssr156772	Chr19:46490251-46490271 (+)	174 bp
Tssr156773	Chr19:46490729-46490764 (+)	660 bp
Tssr156774	Chr19:46491319-46491351 (+)	1,248 bp
Tssr156775	Chr19:46499593-46499597 (+)	9,508 bp
Tssr156776	Chr19:46503055-46503070 (+)	12,976 bp
Tssr156777	Chr19:46503761-46503779 (+)	13,683 bp
Tssr156778	Chr19:46504153-46504201 (+)	14,090 bp
Tssr156779	Chr19:46504278-46504295 (+)	14,200 bp
Tssr156780	Chr19:46504592-46504618 (+)	14,518 bp
Tssr156781	Chr19:46504626-46504642 (+)	14,547 bp
Tssr156782	Chr19:46504692-46504748 (+)	14,633 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 04/16/2024 MGI 6.23