About   Help   FAQ
Sycp2 Gene Detail
Summary
  • Symbol
    Sycp2
  • Name
    synaptonemal complex protein 2
  • Synonyms
    3830402K23Rik, 4930518F03Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1933281
    NCBI Gene: 320558
Location & Maps
more
  • Sequence Map
    Chr2:178345293-178407685 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      62393 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 2, 99.81 cM, cytoband H4
  • Mapping Data
    4 experiments
Homology
more
  • Human Ortholog
    SYCP2, synaptonemal complex protein 2
  • Vertebrate Orthologs
    9
  • Human Ortholog
    SYCP2, synaptonemal complex protein 2
    Orthology source: HomoloGene, HGNC
  • Synonyms
    SCP2, SCP-2
  • Links
    NCBI Gene ID: 10388
    neXtProt AC: NX_Q9BX26

  • Chr Location
    20q13.33; chr20:59863557-59933681 (-)  GRCh38.p2

  • HomoloGene
    Vertebrate Homology Class 8604
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: SYCP2
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    13 phenotypes from 1 allele in 1 genetic background
    3 images
    5 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Male mice homozygous for a knock-out allele are sterile due to lack of axial element formation and subsequent failure of chromosome synapsis in prophase I spermatocytes, while females are subfertile with a sharply reduced litter size.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000016353 VEGA Gene Model | MGI Sequence Detail 62393 C57BL/6J ±  kb
transcript OTTMUST00000039321 VEGA | MGI Sequence Detail 5717 Not Applicable  
polypeptide OTTMUSP00000017573 VEGA | MGI Sequence Detail 1500 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    200 from dbSNP Build 142
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 15
    cDNA 13
    Primer pair 1
    Other 1

    Microarray probesets 2
Other
Accession IDs
less
MGI:1917938, MGI:2444271
References
more
  • Summaries
    All 41
    Developmental Gene Expression 8
    Gene Ontology 11
    Phenotypes 5
  • Earliest
    J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
  • Latest
    J:225272 Zhou J, et al., Accelerated reproductive aging in females lacking a novel centromere protein SYCP2L. Hum Mol Genet. 2015 Nov;24(22):6505-14

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
11/29/2016
MGI 6.06
The Jackson Laboratory