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Gtf2a1 Gene Detail
Summary
  • Symbol
    Gtf2a1
  • Name
    general transcription factor II A, 1
  • Synonyms
    19kDa, 37kDa, 6330549H03Rik, Tfiia1, TfIIAa/b
  • Feature Type
    protein coding gene
  • IDs
    MGI:1933277
    NCBI Gene: 83602
  • Gene Overview
    MyGene.info: GTF2A1
Location & Maps
more
  • Sequence Map
    Chr12:91555916-91590487 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      34572 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 12, 45.02 cM, cytoband E
  • Mapping Data
    3 experiments
Homology
more
  • Human Ortholog
    GTF2A1, general transcription factor IIA subunit 1
  • Vertebrate Orthologs
    10
  • Human Ortholog
    GTF2A1, general transcription factor IIA subunit 1
    Orthology source: HomoloGene, HGNC
  • Synonyms
    TF2A1, TFIIA, TFIIA-42, TFIIAL
  • Links
    NCBI Gene ID: 2957
    neXtProt AC: NX_P52655

  • Chr Location
    14q31.1; chr14:81175452-81221231 (-)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    14 phenotypes from 2 alleles in 2 genetic backgrounds
    17 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    73
  • Chemically induced (other)
    1
  • Gene trapped
    66
  • Targeted
    6
  • Genomic Mutations
    1 involving Gtf2a1
  • Incidental Mutations
Mice homozygous for a hypomorphic allele where D/G cleavage residues are replaced with noncleavable A/A show neonatal lethality, feeding defects, low testis weight, and male infertility associated with azoospermia, small seminiferous tubules, lack of elongating spermatids, and increased apoptosis.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000035545 VEGA Gene Model | MGI Sequence Detail 34572 C57BL/6J ±  kb
transcript OTTMUST00000091041 VEGA | MGI Sequence Detail 5410 Not Applicable  
polypeptide OTTMUSP00000050089 VEGA | MGI Sequence Detail 378 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    142 from dbSNP Build 142
Protein
Information
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  • UniProt
    4 Sequences
  • Protein Ontology
    PR:000008310 transcription initiation factor IIA subunit 1
  • InterPro Domains
    IPR004855 Transcription factor IIA, alpha/beta subunit
    IPR013028 Transcription factor IIA, alpha subunit, N-terminal
    IPR009088 Transcription factor IIA, beta-barrel
    IPR009083 Transcription factor IIA, helical
Molecular
Reagents
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  • All nucleic 22
    cDNA 19
    Primer pair 3

    Microarray probesets 6
Other
Accession IDs
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MGI:1915037, MGI:2144740, MGI:2144749, MGI:2144998
References
more
  • Summaries
    All 52
    Developmental Gene Expression 8
    Gene Ontology 6
    Phenotypes 17
  • Earliest
    J:93290 Araki K, et al., Exchangeable gene trap using the Cre/mutated lox system. Cell Mol Biol (Noisy-le-grand). 1999 Jul;45(5):737-50
  • Latest
    J:220544 Takeda S, et al., Taspase1-dependent TFIIA cleavage coordinates head morphogenesis by limiting Cdkn2a locus transcription. J Clin Invest. 2015 Mar 2;125(3):1203-14

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/29/2016
MGI 6.06
The Jackson Laboratory