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Gtf2a1
Gene Detail
Symbol

Name
ID
Gtf2a1
general transcription factor II A, 1
MGI:1933277
Synonyms
19kDa, 37kDa, 6330549H03Rik, Tfiia1, TfIIAa/b
Feature Type
protein coding gene
Genetic Map
Chromosome 12
45.02 cM, cytoband E
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr12:91555916-91590487 bp, - strand
From VEGA annotation of GRCm38

  34572 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:56331  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: hypothetical protein, Caenorhabditis elegans K11D12.2 type
Gene Tree: Gtf2a1

Human
homologs
Human Homolog GTF2A1, general transcription factor IIA, 1, 19/37kDa
NCBI Gene ID 2957
neXtProt AC  NX_P52655
Human Synonyms  TF2A1, TFIIA, TFIIA-42, TFIIAL
Human Chr (Location)  14q31.1; chr14:81175452-81221231 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(72) : Gene trapped(66) Targeted(6)
Incidental mutations (data from Mutagenetix , APF )
Interactions
Gtf2a1 interacts with 399 markers (Mir1b, Mir7-1, Mir7-2, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (18 annotations)
Process regulation of transcription, DNA-templated, transcription, DNA-templated, ...
Component cytoplasm, nucleoplasm, ...
Function DNA binding, protein binding, ...
External Resources: FuncBase
Expression
Literature Summary: (7 records)
Data Summary: Results (87)    Tissues (61)    Images (22)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 62
RT-PCR 25
cDNA source data(17)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(22) cDNA(19) Primer pair(3)
Microarray probesets(6)
Other database
links
VEGA Gene ModelOTTMUSG00000035545 (Evidence)
Ensembl Gene ModelENSMUSG00000020962 (Evidence)
Entrez Gene83602 (Evidence)
DFCITC1584567, TC1590047, TC1598148, TC1616878
DoTSDT.97370900, DT.101366357
NIA Mouse Gene IndexU034229
Consensus CDS ProjectCCDS26089.1, CCDS49136.1
International Mouse Knockout Project StatusGtf2a1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000035545 VEGA Gene Model | MGI Sequence Detail 34572 C57BL/6J ±  kb
transcript OTTMUST00000091041 VEGA | MGI Sequence Detail 5410 Not Applicable 
polypeptide OTTMUSP00000050089 VEGA | MGI Sequence Detail 378 Not Applicable 

For the selected sequences
All sequences(53) RefSeq(6) UniProt(7)
Polymorphisms
SNPs within 2kb(161 from dbSNP Build 137)    SNPs within 2kb including multiple locations(199)
Protein-related
information
ResourceIDDescription
InterPro IPR004855 Transcription factor IIA, alpha/beta subunit
InterPro IPR013028 Transcription factor IIA, alpha subunit, N-terminal
InterPro IPR009088 Transcription factor IIA, beta-barrel
InterPro IPR009083 Transcription factor IIA, helical
Protein Ontology PR:000008310 transcription initiation factor IIA subunit 1
References
(Earliest) J:93290 Araki K, et al., Exchangeable gene trap using the Cre/mutated lox system. Cell Mol Biol (Noisy-le-grand). 1999 Jul;45(5):737-50
(Latest) J:205038 Oyama T, et al., Cleavage of TFIIA by Taspase1 activates TRF2-specified mammalian male germ cell programs. Dev Cell. 2013 Oct 28;27(2):188-200
All references(54)
Other
accession IDs
MGI:1915037, MGI:2144740, MGI:2144749, MGI:2144998

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
12/09/2014
MGI 5.20
The Jackson Laboratory