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Gtf2a1
Gene Detail
Symbol

Name
ID
Gtf2a1
general transcription factor II A, 1
MGI:1933277
Synonyms
19kDa, 37kDa, 6330549H03Rik, Tfiia1, TfIIAa/b
Feature Type
protein coding gene
Genetic Map
Chromosome 12
45.02 cM, cytoband E
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr12:91555916-91590487 bp, - strand
From VEGA annotation of GRCm38

  34572 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:56331  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: GTF2A1
Protein SuperFamily: hypothetical protein, Caenorhabditis elegans K11D12.2 type
Gene Tree: Gtf2a1

Human
homologs
GTF2A1, general transcription factor IIA, 1, 19/37kDa
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 2957
neXtProt AC: NX_P52655

Human Synonyms: TF2A1, TFIIA, TFIIA-42, TFIIAL

Human Chr (Location): 14q31.1; chr14:81175452-81221231 (-)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(72) : Gene trapped(66) Targeted(6)
Incidental mutations (data from Mutagenetix , APF )
Interactions
Gtf2a1 interacts with 399 markers (Mir1b, Mir7-1, Mir7-2, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (18 annotations)
Process regulation of transcription, DNA-templated, transcription, DNA-templated, ...
Component cytoplasm, nucleoplasm, ...
Function DNA binding, protein binding, ...
External Resources: FuncBase
Expression
Literature Summary: (8 records)
Data Summary: Results (87)    Tissues (61)    Images (22)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 62
RT-PCR 25
cDNA source data(17)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase gtf2a1 ; ZFIN gtf2a1    NEW 
Molecular
reagents
All nucleic(22) cDNA(19) Primer pair(3)
Microarray probesets(6)
Other database
links
VEGA Gene Model OTTMUSG00000035545 (Evidence)
Ensembl Gene Model ENSMUSG00000020962 (Evidence)
Entrez Gene 83602 (Evidence)
DFCI TC1590047, TC1584567, TC1616878, TC1598148
DoTS DT.97370900, DT.101366357
NIA Mouse Gene Index U034229
Consensus CDS Project CCDS26089.1, CCDS49136.1
International Mouse Phenotyping Consortium Status Gtf2a1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000035545 VEGA Gene Model | MGI Sequence Detail 34572 C57BL/6J ±  kb
transcript OTTMUST00000091041 VEGA | MGI Sequence Detail 5410 Not Applicable 
polypeptide OTTMUSP00000050089 VEGA | MGI Sequence Detail 378 Not Applicable 

For the selected sequences
All sequences(50) RefSeq(6) UniProt(4)
Polymorphisms
SNPs within 2kb(161 from dbSNP Build 137)    SNPs within 2kb including multiple locations(199)
Protein-related
information
ResourceIDDescription
InterPro IPR004855 Transcription factor IIA, alpha/beta subunit
InterPro IPR013028 Transcription factor IIA, alpha subunit, N-terminal
InterPro IPR009088 Transcription factor IIA, beta-barrel
InterPro IPR009083 Transcription factor IIA, helical
Protein Ontology PR:000008310 transcription initiation factor IIA subunit 1
References
(Earliest) J:93290 Araki K, et al., Exchangeable gene trap using the Cre/mutated lox system. Cell Mol Biol (Noisy-le-grand). 1999 Jul;45(5):737-50
(Latest) J:220544 Takeda S, et al., Taspase1-dependent TFIIA cleavage coordinates head morphogenesis by limiting Cdkn2a locus transcription. J Clin Invest. 2015 Mar 2;125(3):1203-14
All references(55)
Other
accession IDs
MGI:1915037, MGI:2144740, MGI:2144749, MGI:2144998

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/21/2015
MGI 5.22
The Jackson Laboratory