Tktl1 MGI Mouse Gene Detail - MGI:1933244

Symbol

Tktl1
Name

transketolase-like 1

Feature Type

protein coding gene
IDs

MGI:1933244
NCBI Gene: 83553
Alliance

gene page
Transcription Start Sites

4 TSS

Sequence Map

ChrX:73220865-73252104 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome X, 37.83 cM
Mapping Data

2 experiments

SNPs within 2kb

140 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1933244	protein coding gene	ChrX:73220865-73252106 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0035833	protein coding gene	ChrX:69966824-69998218 (+)
A/J	MGP_AJ_G0035814	protein coding gene	ChrX:70158249-70191067 (+)
AKR/J	MGP_AKRJ_G0035739	protein coding gene	ChrX:72049885-72082832 (+)
BALB/cJ	MGP_BALBcJ_G0035799	protein coding gene	ChrX:69183297-69214517 (+)
C3H/HeJ	MGP_C3HHeJ_G0035504	protein coding gene	ChrX:70440752-70471486 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0036329	protein coding gene	ChrX:72132755-72162695 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0033173	protein coding gene	ChrX:69221089-69252810 (+)
CAST/EiJ	MGP_CASTEiJ_G0034795	protein coding gene	ChrX:55820785-55851117 (+)
CBA/J	MGP_CBAJ_G0035479	protein coding gene	ChrX:74119664-74151875 (+)
DBA/2J	MGP_DBA2J_G0035636	protein coding gene	ChrX:69609344-69642799 (+)
FVB/NJ	MGP_FVBNJ_G0035580	protein coding gene	ChrX:68962208-68991647 (+)
LP/J	MGP_LPJ_G0035721	protein coding gene	ChrX:70750760-70782490 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0035618	protein coding gene	ChrX:76676122-76711096 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0036351	protein coding gene	ChrX:69790222-69820606 (+)
PWK/PhJ	MGP_PWKPhJ_G0034494	protein coding gene	ChrX:53794842-53825255 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0034328	protein coding gene	ChrX:56699589-56729623 (+)
WSB/EiJ	MGP_WSBEiJ_G0034936	protein coding gene	ChrX:69064469-69095426 (+)

Human Ortholog

TKTL1, transketolase like 1

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

TKTL1, transketolase like 1
Synonyms

TKR, TKT2
Links

HGNC:11835

NCBI Gene ID: 8277

neXtProt AC: NX_P51854

UniProt: P51854
Chr Location

Xq28; chrX:154295795-154330350 (+) GRCh38

MGI Vertebrate Homology

Tktl1 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: TKTL1
Gene Tree

Tktl1

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Phenotype Summary

3 phenotypes from 2 alleles in 2 genetic backgrounds
7 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

8
Endonuclease-mediated

5
Targeted

3
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

9 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a knock-out allele exhibit increased susceptibility to DSS-induced colitis. Male mice homozygous for a mutation show normal fertility.

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All GO Annotations

5
GO References

4

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

806
Tissues

100
cDNA Data

9
Literature Summary

4

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas

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All Sequences

40
RefSeq

2
UniProt

2
CCDS

CCDS30221.1

Ensembl

ENSMUSG00000031397 (Evidence)
NCBI Gene

83553

			Length	Strain/Species	Flank
genomic	83553	NCBI Gene Model \| MGI Sequence Detail	31240	C57BL/6J	± kb
transcript	NM_031379	RefSeq \| MGI Sequence Detail	2485	C57BL/6
polypeptide	Q99MX0	UniProt \| EBI \| MGI Sequence Detail	595	Not Applicable

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UniProt

2 Sequences
Protein Ontology

PR:000016370 transketolase-like protein 1

(term hierarchy)
EC

2.2.1.1
InterPro Domains

IPR029061 Thiamin diphosphate-binding fold

IPR033248 Transketolase, C-terminal domain

IPR009014 Transketolase C-terminal/Pyruvate-ferredoxin oxidoreductase domain II

IPR005475 Transketolase-like, pyrimidine-binding domain

IPR005474 Transketolase, N-terminal

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All nucleic 11

cDNA 9

Primer pair 2

Microarray probesets 5

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MGI:2148059

Summaries

All 34

Developmental Gene Expression 4

Gene Ontology 4

Phenotypes 7
Earliest

J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
Latest

J:326541 Cyagen Biosciences Inc., Cyagen Biosciences Website. 2022;

TSS for Tktl1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr161306	ChrX:73220831-73220842 (+)	-28 bp
Tssr161307	ChrX:73220858-73220874 (+)	1 bp
Tssr161308	ChrX:73246018-73246026 (+)	25,157 bp
Tssr161309	ChrX:73248520-73248532 (+)	27,661 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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