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Tktl1 Gene Detail
Summary
  • Symbol
    Tktl1
  • Name
    transketolase-like 1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1933244
    NCBI Gene: 83553
  • Gene Overview
    MyGene.info: TKTL1
  • Alliance
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    ChrX:74177259-74208498 bp, + strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome X, 37.83 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    140 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1933244
protein coding gene ChrX:74177259-74208500 (.)
129S1/SvImJ MGP_129S1SvImJ_G0035833
protein coding gene ChrX:69966824-69998218 (+)
A/J MGP_AJ_G0035814
protein coding gene ChrX:70158249-70191067 (+)
AKR/J MGP_AKRJ_G0035739
protein coding gene ChrX:72049885-72082832 (+)
BALB/cJ MGP_BALBcJ_G0035799
protein coding gene ChrX:69183297-69214517 (+)
C3H/HeJ MGP_C3HHeJ_G0035504
protein coding gene ChrX:70440752-70471486 (+)
C57BL/6NJ MGP_C57BL6NJ_G0036329
protein coding gene ChrX:72132755-72162695 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0033173
protein coding gene ChrX:69221089-69252810 (+)
CAST/EiJ MGP_CASTEiJ_G0034795
protein coding gene ChrX:55820785-55851117 (+)
CBA/J MGP_CBAJ_G0035479
protein coding gene ChrX:74119664-74151875 (+)
DBA/2J MGP_DBA2J_G0035636
protein coding gene ChrX:69609344-69642799 (+)
FVB/NJ MGP_FVBNJ_G0035580
protein coding gene ChrX:68962208-68991647 (+)
LP/J MGP_LPJ_G0035721
protein coding gene ChrX:70750760-70782490 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0035618
protein coding gene ChrX:76676122-76711096 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0036351
protein coding gene ChrX:69790222-69820606 (+)
PWK/PhJ MGP_PWKPhJ_G0034494
protein coding gene ChrX:53794842-53825255 (+)
SPRET/EiJ MGP_SPRETEiJ_G0034328
protein coding gene ChrX:56699589-56729623 (+)
WSB/EiJ MGP_WSBEiJ_G0034936
protein coding gene ChrX:69064469-69095426 (+)



Homology
more
  • Human Ortholog
    TKTL1, transketolase like 1
  • Vertebrate Orthologs
    7
  • Human Ortholog
    TKTL1, transketolase like 1
    Orthology source: HomoloGene, HGNC
  • Synonyms
    TKR, TKT2
  • Links
    NCBI Gene ID: 8277
    neXtProt AC: NX_P51854
    UniProt: P51854

  • Chr Location
    Xq28; chrX:154295674-154330363 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    3 phenotypes from 2 alleles in 2 genetic backgrounds
    4 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit increased susceptibility to DSS-induced colitis. Male mice homozygous for a mutation show normal fertility.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 83553 NCBI Gene Model | MGI Sequence Detail 31240 C57BL/6J ±  kb
transcript NM_031379 RefSeq | MGI Sequence Detail 2485 C57BL/6  
polypeptide Q99MX0 UniProt | EBI | MGI Sequence Detail 595 Not Applicable  
For the selected sequence
Protein
Information
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  • UniProt
    2 Sequences
  • EC
  • InterPro Domains
    IPR029061 Thiamin diphosphate-binding fold
    IPR033248 Transketolase, C-terminal domain
    IPR009014 Transketolase C-terminal/Pyruvate-ferredoxin oxidoreductase domain II
    IPR005475 Transketolase-like, pyrimidine-binding domain
    IPR005474 Transketolase, N-terminal
Molecular
Reagents
less
  • All nucleic 11
    cDNA 9
    Primer pair 2

    Microarray probesets 5
Other
Accession IDs
less
MGI:2148059
References
more
  • Summaries
    All 29
    Developmental Gene Expression 3
    Gene Ontology 3
    Phenotypes 4
  • Earliest
    J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
  • Latest
    J:242046 Sharma S, et al., Mitochondrial complex II regulates a distinct oxygen sensing mechanism in monocytes. Hum Mol Genet. 2017 Apr 01;26(7):1328-1339

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/06/2018
MGI 6.13
The Jackson Laboratory