Grin3a
Gene Detail

Symbol Name ID

Grin3a glutamate receptor ionotropic, NMDA3A MGI:1933206

Synonyms

A830097C19Rik, NMDAR-L, NR3A

Feature Type

protein coding gene

Genetic Map

Chromosome 4

26.72 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)

Sequence Map

Chr4:49661611-49845744 bp, - strand From VEGA annotation of GRCm38   184134 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Mammalian homology

human; rat; cattle; chimpanzee; dog, domestic    (Mammalian Orthology)
Comparative Map (Mouse/Human Grin3a ± 2 cM)

Gene Tree: Grin3a

Human ortholog

GRIN3A glutamate receptor, ionotropic, N-methyl-D-aspartate 3A NCBI Gene ID 116443
Human Synonyms: GluN3A, NMDAR-L, NR3A
Human Chr9:104331634-104500862 bp, - strand Reference GRCh37.p2 Primary Assembly

Alleles and phenotypes

All alleles(3) : Targeted(3)
 

Mice homozygous for a disruption in this gene display increased current densities in some cerebrocortical neurons of the brain, increased levels of prepulse inhibition, and altered dendritic spine morphology. Otherwise, they display a normal phenotype.

 

Gene Ontology (GO) classifications

All GO classifications: (40 annotations)

Process	calcium ion transmembrane transport, calcium ion transport, ...
Component	cell junction, integral to membrane, ...
Function	calcium channel activity, glycine binding, ...

This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase

Expression

Literature Summary: (4 records)
Data Summary: Results (134)    Tissues (22)    Images (24)
Theiler Stages: 23

Assay Type	Results
RNA in situ	134

cDNA source data(6)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(6) cDNA(6)
Microarray probesets(4)

Other database links

VEGA Gene Model	OTTMUSG00000006949 (Evidence)
Ensembl Gene Model	ENSMUSG00000039579 (Evidence)
Entrez Gene	242443 (Evidence)
DFCI	TC1605701, TC1716671
DoTS	DT.101198801, DT.110834110, DT.40165168, DT.55282495, DT.91330666, DT.91393704
Consensus CDS Project	CCDS51175.1
International Mouse Knockout Project Status	Grin3a

Sequences

Length	Strain/Species
genomic	OTTMUSG00000006949	VEGA Gene Model | MGI Sequence Detail	184134	C57BL/6J
transcript	OTTMUST00000016089	VEGA | MGI Sequence Detail	7491	Not Applicable
polypeptide	OTTMUSP00000007378	VEGA | MGI Sequence Detail	1135	Not Applicable

All sequences(42) RefSeq(5) UniProt(4)

Protein-related information

Resource	ID	Description
InterPro	IPR001638	Extracellular solute-binding protein, family 3
InterPro	IPR019594	Glutamate receptor, L-glutamate/glycine-binding
InterPro	IPR001320	Ionotropic glutamate receptor
InterPro	IPR001508	NMDA receptor

References

(Earliest) J:66481 Das S, et al., Increased NMDA current and spine density in mice lacking the NMDA receptor subunit NR3A. Nature. 1998 May 28;393(6683):377-81
(Latest) J:189657 Henson MA, et al., Genetic deletion of NR3A accelerates glutamatergic synapse maturation. PLoS One. 2012;7(8):e42327
All references(39)

Other accession IDs

MGI:3036253