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Grin3a Gene Detail
Summary
  • Symbol
    Grin3a
  • Name
    glutamate receptor ionotropic, NMDA3A
  • Synonyms
    A830097C19Rik, NMDAR-L, NR3A
  • Feature Type
    protein coding gene
  • IDs
    MGI:1933206
    NCBI Gene: 242443
  • Gene Overview
    MyGene.info: GRIN3A
  • Alliance
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr4:49661611-49845744 bp, - strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 4, 26.72 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    1321 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1933206
protein coding gene Chr4:49661611-49845769 (-)
129S1/SvImJ MGP_129S1SvImJ_G0028287
protein coding gene Chr4:48145645-48342576 (-)
A/J MGP_AJ_G0028247
protein coding gene Chr4:46370407-46549078 (-)
AKR/J MGP_AKRJ_G0028196
protein coding gene Chr4:47583894-47771931 (-)
BALB/cJ MGP_BALBcJ_G0028266
protein coding gene Chr4:46476294-46666434 (-)
C3H/HeJ MGP_C3HHeJ_G0027987
protein coding gene Chr4:48153260-48356488 (-)
C57BL/6NJ MGP_C57BL6NJ_G0028707
protein coding gene Chr4:49879270-50076418 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0026016
protein coding gene Chr4:43572407-43748466 (-)
CAST/EiJ MGP_CASTEiJ_G0027426
protein coding gene Chr4:47712096-47903467 (-)
CBA/J MGP_CBAJ_G0027953
protein coding gene Chr4:51581810-51785119 (-)
DBA/2J MGP_DBA2J_G0028103
protein coding gene Chr4:46252858-46431905 (-)
FVB/NJ MGP_FVBNJ_G0028070
protein coding gene Chr4:45515733-45695438 (-)
LP/J MGP_LPJ_G0028202
protein coding gene Chr4:48223392-48416573 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0028094
protein coding gene Chr4:54503292-54700150 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0028742
protein coding gene Chr4:47791625-47972777 (-)
PWK/PhJ MGP_PWKPhJ_G0027151
protein coding gene Chr4:46327439-46510150 (-)
SPRET/EiJ MGP_SPRETEiJ_G0026979
protein coding gene Chr4:47160885-47364040 (-)
WSB/EiJ MGP_WSBEiJ_G0027504
protein coding gene Chr4:47686704-47882521 (-)



Homology
more
  • Human Ortholog
    GRIN3A, glutamate ionotropic receptor NMDA type subunit 3A
  • Vertebrate Orthologs
    9
  • Human Ortholog
    GRIN3A, glutamate ionotropic receptor NMDA type subunit 3A
    Orthology source: HomoloGene, HGNC
  • Synonyms
    GluN3A, NMDAR-L, NR3A
  • Links
    NCBI Gene ID: 116443
    neXtProt AC: NX_Q8TCU5
    UniProt: Q8TCU5

  • Chr Location
    9q31.1; chr9:101569352-101738580 (-)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    6 phenotypes from 2 alleles in 3 genetic backgrounds
    20 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a disruption in this gene display increased current densities in some cerebrocortical neurons of the brain, increased levels of prepulse inhibition, and altered dendritic spine morphology. Otherwise, they display a normal phenotype.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000039579 Ensembl Gene Model | MGI Sequence Detail 184134 C57BL/6J ±  kb
transcript ENSMUST00000093859 Ensembl | MGI Sequence Detail 7491 Not Applicable  
polypeptide ENSMUSP00000091381 Ensembl | MGI Sequence Detail 1135 Not Applicable  
For the selected sequence
Protein
Information
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  • UniProt
    4 Sequences
  • InterPro Domains
    IPR001320 Ionotropic glutamate receptor
    IPR019594 Ionotropic glutamate receptor, L-glutamate and glycine-binding domain
    IPR001508 Ionotropic glutamate receptor, metazoa
    IPR028082 Periplasmic binding protein-like I
    IPR001828 Receptor, ligand binding region
Molecular
Reagents
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  • All nucleic 22
    cDNA 22

    Microarray probesets 4
Other
Accession IDs
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MGI:3036253
References
more
  • Summaries
    All 53
    Developmental Gene Expression 5
    Gene Ontology 9
    Phenotypes 20
  • Earliest
    J:6648 Billings-Gagliardi S, et al., Hypomyelinated mutant mice IV: peripheral myelin in jp msd. Brain Res. 1981 Nov 30;225(2):309-17
  • Latest
    J:240852 Mahfooz K, et al., GluN3A promotes NMDA spiking by enhancing synaptic transmission in Huntington's disease models. Neurobiol Dis. 2016 Sep;93:47-56

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/13/2018
MGI 6.13
The Jackson Laboratory