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Grin3a Gene Detail
Summary
  • Symbol
    Grin3a
  • Name
    glutamate receptor ionotropic, NMDA3A
  • Synonyms
    A830097C19Rik, NMDAR-L, NR3A
  • Feature Type
    protein coding gene
  • IDs
    MGI:1933206
    NCBI Gene: 242443
  • Alliance
    genome feature page
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr4:49661611-49845744 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 4, 26.72 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    4864 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1933206
 protein coding gene Chr4:49661611-49846023 (-)
129S1/SvImJ ENSMUSG00200002576
 protein coding gene Chr4:45737790-45927654 (-)
A/J ENSMUSG00195005676
 protein coding gene Chr4:46157018-46354773 (-)
AKR/J ENSMUSG00220002249
 protein coding gene Chr4:45881608-46065644 (-)
BALB/cJ ENSMUSG00180029828
 protein coding gene Chr4:45743686-45941443 (-)
C3H/HeJ ENSMUSG00175021064
 protein coding gene Chr4:45892574-46090319 (-)
C57BL/6NJ ENSMUSG00215022123
 protein coding gene Chr4:45690645-45890402 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0026016
 protein coding gene Chr4:43572407-43748466 (-)
CAST/EiJ ENSTCUG00005036015
 protein coding gene Chr4:46006168-46187794 (-)
CBA/J ENSMUSG00210019503
 protein coding gene Chr4:45597287-45787419 (-)
DBA/2J ENSMUSG00185031241
 protein coding gene Chr4:45955784-46145920 (-)
FVB/NJ ENSMUSG00205017092
 protein coding gene Chr4:45248497-45432535 (-)
JF1/MsJ ENSUMUG00000026139
 protein coding gene Chr4:46257057-46441908 (-)
LP/J ENSMUSG00230038793
 protein coding gene Chr4:49533522-49723357 (-)
NOD/ShiLtJ ENSMUSG00190021751
 protein coding gene Chr4:45846600-46037624 (-)
NZO/HlLtJ ENSMUSG00225002138
 protein coding gene Chr4:54125707-54309699 (-)
PWK/PhJ ENSLUMG00010012174
 protein coding gene Chr4:45163264-45348215 (-)
SPRET/EiJ ENSMSPG00010008396
 protein coding gene Chr4:46210597-46414760 (-)
WSB/EiJ ENSIUOG00005004087
 protein coding gene Chr4:45578167-45766839 (-)



Homology
more
  • Human Ortholog
    GRIN3A, glutamate ionotropic receptor NMDA type subunit 3A
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    GRIN3A, glutamate ionotropic receptor NMDA type subunit 3A
  • Synonyms
    GluN3A, NMDAR3A, NMDAR-L, NR3A
  • Links
    NCBI Gene ID: 116443
    UniProt: Q8TCU5

  • Chr Location
    9q31.1; chr9:101569352-101738647 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    6 phenotypes from 3 alleles in 4 genetic backgrounds
    1 phenotype from multigenic genotypes
    38 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a disruption in this gene display increased current densities in some cerebrocortical neurons of the brain, increased levels of prepulse inhibition, and altered dendritic spine morphology. Otherwise, they display a normal phenotype.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    114
  • GO References
    14
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    770
  • Tissues
    42
  • cDNA Data
    22
  • Literature Summary
    12
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000039579 Ensembl Gene Model | MGI Sequence Detail 184134 C57BL/6J ±  kb
    transcript ENSMUST00000093859 Ensembl | MGI Sequence Detail 7491 Not Applicable  
    polypeptide ENSMUSP00000091381 Ensembl | MGI Sequence Detail 1135 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      2 Sequences
    • Protein Ontology
      PR:000008250 glutamate receptor ionotropic, NMDA 3A
      (term hierarchy)
    • InterPro Domains
      IPR015683 Ionotropic glutamate receptor
      IPR001320 Ionotropic glutamate receptor, C-terminal
      IPR019594 Ionotropic glutamate receptor, L-glutamate and glycine-binding domain
      IPR001508 Ionotropic glutamate receptor, metazoa
      IPR028082 Periplasmic binding protein-like I
      IPR001828 Receptor, ligand binding region
    • GlyGen
      A2AIR5 12 sites, 7 N-linked glycans (5 sites)
    Molecular
    Reagents
    less
    • All nucleic 22
      cDNA 22
      Antibodies 1

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGI:3036253
    References
    more
    • Summaries
      All 85
      Developmental Gene Expression 12
      Gene Ontology 14
      Phenotypes 38
    • Earliest
      J:6648 Billings-Gagliardi S, et al., Hypomyelinated mutant mice IV: peripheral myelin in jp msd. Brain Res. 1981 Nov 30;225(2):309-17
    • Latest
      J:389827 Pizzamiglio L, et al., Excitatory glycine receptors control ventral hippocampus synaptic plasticity and anxiety-related behaviors. Proc Natl Acad Sci U S A. 2025 Sep 16;122(37):e2501118122
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/15/2026
    MGI 6.29     		The Jackson Laboratory