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Grin3a Gene Detail
Summary
  • Symbol
    Grin3a
  • Name
    glutamate receptor ionotropic, NMDA3A
  • Synonyms
    A830097C19Rik, NMDAR-L, NR3A
  • Feature Type
    protein coding gene
  • IDs
    MGI:1933206
    NCBI Gene: 242443
  • Gene Overview
    MyGene.info: GRIN3A
Location & Maps
more
  • Sequence Map
    Chr4:49661611-49845744 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      184134 bp   ±  kb flank

  • Genome Browsers
Homology
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  • Human Ortholog
    GRIN3A, glutamate ionotropic receptor NMDA type subunit 3A
  • Vertebrate Orthologs
    9
  • Human Ortholog
    GRIN3A, glutamate ionotropic receptor NMDA type subunit 3A
    Orthology source: HomoloGene
  • Synonyms
    GluN3A, NMDAR-L, NR3A
  • Links
    NCBI Gene ID: 116443
    neXtProt AC: NX_Q8TCU5

  • Chr Location
    9q31.1; chr9:101569352-101738580 (-)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    6 phenotypes from 2 alleles in 3 genetic backgrounds
    17 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryogenesis
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
tumorigenesis
vision/eye

Click cells to view annotations.
Mice homozygous for a disruption in this gene display increased current densities in some cerebrocortical neurons of the brain, increased levels of prepulse inhibition, and altered dendritic spine morphology. Otherwise, they display a normal phenotype.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000006949 VEGA Gene Model | MGI Sequence Detail 184134 C57BL/6J ±  kb
transcript OTTMUST00000016089 VEGA | MGI Sequence Detail 7491 Not Applicable  
polypeptide OTTMUSP00000007378 VEGA | MGI Sequence Detail 1135 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    1321 from dbSNP Build 142
Protein
Information
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  • UniProt
    4 Sequences
  • InterPro Domains
    IPR001320 Ionotropic glutamate receptor
    IPR019594 Ionotropic glutamate receptor, L-glutamate and glycine-binding domain
    IPR001508 Ionotropic glutamate receptor, metazoa
    IPR028082 Periplasmic binding protein-like I
Molecular
Reagents
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  • All nucleic 20
    cDNA 20

    Microarray probesets 4
Other
Accession IDs
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MGI:3036253
References
more
  • Summaries
    All 45
    Developmental Gene Expression 4
    Gene Ontology 6
    Phenotypes 17
  • Earliest
    J:66481 Das S, et al., Increased NMDA current and spine density in mice lacking the NMDA receptor subunit NR3A. Nature. 1998 May 28;393(6683):377-81
  • Latest
    J:224013 Lee JH, et al., A neuroprotective role of the NMDA receptor subunit GluN3A (NR3A) in ischemic stroke of the adult mouse. Am J Physiol Cell Physiol. 2015 Apr 1;308(7):C570-7

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
05/17/2016
MGI 6.03
The Jackson Laboratory