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Grin3a
Gene Detail
Symbol

Name
ID
Grin3a
glutamate receptor ionotropic, NMDA3A
MGI:1933206
Synonyms
A830097C19Rik, NMDAR-L, NR3A
Feature Type
protein coding gene
Genetic Map
Chromosome 4
26.72 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr4:49661611-49845744 bp, - strand
From VEGA annotation of GRCm38

  184134 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:128613  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog

Gene Tree: Grin3a

Human
homologs
Human Homolog GRIN3A, glutamate receptor, ionotropic, N-methyl-D-aspartate 3A
NCBI Gene ID 116443
neXtProt AC  NX_Q8TCU5
Human Synonyms  GluN3A, NMDAR-L, NR3A
Human Chr (Location)  9q31.1; chr9:101569352-101738580 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(3) : Targeted(3)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a disruption in this gene display increased current densities in some cerebrocortical neurons of the brain, increased levels of prepulse inhibition, and altered dendritic spine morphology. Otherwise, they display a normal phenotype.
 
Interactions
Grin3a interacts with 400 markers (Mir1a-2, Mir7-1, Mir7-2, ...)
Gene Ontology
(GO)
classifications
Expression
Literature Summary: (4 records)
Data Summary: Results (134)    Tissues (22)    Images (24)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 134
cDNA source data(20)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(20) cDNA(20)
Microarray probesets(4)
Other database
links
VEGA Gene ModelOTTMUSG00000006949 (Evidence)
Ensembl Gene ModelENSMUSG00000039579 (Evidence)
Entrez Gene242443 (Evidence)
UniGene440095
DFCITC1716671, TC1605701
DoTSDT.101198801, DT.110834110, DT.91393704, DT.40165168, DT.91330666, DT.55282495
Consensus CDS ProjectCCDS51175.1, CCDS71385.1
International Mouse Knockout Project StatusGrin3a
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000006949 VEGA Gene Model | MGI Sequence Detail 184134 C57BL/6J ±  kb
transcript OTTMUST00000016089 VEGA | MGI Sequence Detail 7491 Not Applicable 
polypeptide OTTMUSP00000007378 VEGA | MGI Sequence Detail 1135 Not Applicable 

For the selected sequences
All sequences(50) RefSeq(9) UniProt(8)
Polymorphisms
SNPs within 2kb(1331 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001638 Extracellular solute-binding protein, family 3
InterPro IPR019594 Glutamate receptor, L-glutamate/glycine-binding
InterPro IPR001320 Ionotropic glutamate receptor
InterPro IPR001508 NMDA receptor
Protein Ontology PR:000008250 glutamate receptor ionotropic, NMDA 3A
References
(Earliest) J:66481 Das S, et al., Increased NMDA current and spine density in mice lacking the NMDA receptor subunit NR3A. Nature. 1998 May 28;393(6683):377-81
(Latest) J:205503 Fiuza M, et al., GluN3A expression restricts spine maturation via inhibition of GIT1/Rac1 signaling. Proc Natl Acad Sci U S A. 2013 Dec 17;110(51):20807-12
All references(46)
Other
accession IDs
MGI:3036253

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
12/09/2014
MGI 5.20
The Jackson Laboratory