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Grin3a Gene Detail
Summary
  • Symbol
    Grin3a
  • Name
    glutamate receptor ionotropic, NMDA3A
  • Synonyms
    A830097C19Rik, NMDAR-L, NR3A
  • Feature Type
    protein coding gene
  • IDs
    MGI:1933206
    NCBI Gene: 242443
  • Alliance
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr4:49661611-49845744 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
  • Genetic Map
    Chromosome 4, 26.72 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    1320 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1933206
protein coding gene Chr4:49661611-49846023 (-)
129S1/SvImJ MGP_129S1SvImJ_G0028287
protein coding gene Chr4:48145645-48342576 (-)
A/J MGP_AJ_G0028247
protein coding gene Chr4:46370407-46549078 (-)
AKR/J MGP_AKRJ_G0028196
protein coding gene Chr4:47583894-47771931 (-)
BALB/cJ MGP_BALBcJ_G0028266
protein coding gene Chr4:46476294-46666434 (-)
C3H/HeJ MGP_C3HHeJ_G0027987
protein coding gene Chr4:48153260-48356488 (-)
C57BL/6NJ MGP_C57BL6NJ_G0028707
protein coding gene Chr4:49879270-50076418 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0026016
protein coding gene Chr4:43572407-43748466 (-)
CAST/EiJ MGP_CASTEiJ_G0027426
protein coding gene Chr4:47712096-47903467 (-)
CBA/J MGP_CBAJ_G0027953
protein coding gene Chr4:51581810-51785119 (-)
DBA/2J MGP_DBA2J_G0028103
protein coding gene Chr4:46252858-46431905 (-)
FVB/NJ MGP_FVBNJ_G0028070
protein coding gene Chr4:45515733-45695438 (-)
LP/J MGP_LPJ_G0028202
protein coding gene Chr4:48223392-48416573 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0028094
protein coding gene Chr4:54503292-54700150 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0028742
protein coding gene Chr4:47791625-47972777 (-)
PWK/PhJ MGP_PWKPhJ_G0027151
protein coding gene Chr4:46327439-46510150 (-)
SPRET/EiJ MGP_SPRETEiJ_G0026979
protein coding gene Chr4:47160885-47364040 (-)
WSB/EiJ MGP_WSBEiJ_G0027504
protein coding gene Chr4:47686704-47882521 (-)



Homology
more
  • Human Ortholog
    GRIN3A, glutamate ionotropic receptor NMDA type subunit 3A
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    GRIN3A, glutamate ionotropic receptor NMDA type subunit 3A
  • Synonyms
    GluN3A, NMDAR3A, NMDAR-L, NR3A
  • Links
    NCBI Gene ID: 116443
    neXtProt AC: NX_Q8TCU5
    UniProt: Q8TCU5

  • Chr Location
    9q31.1; chr9:101569352-101738647 (-)  GRCh38

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    7 phenotypes from 3 alleles in 4 genetic backgrounds
    31 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a disruption in this gene display increased current densities in some cerebrocortical neurons of the brain, increased levels of prepulse inhibition, and altered dendritic spine morphology. Otherwise, they display a normal phenotype.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Sequences &
    Gene Models
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    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000039579 Ensembl Gene Model | MGI Sequence Detail 184134 C57BL/6J ±  kb
    transcript ENSMUST00000093859 Ensembl | MGI Sequence Detail 7491 Not Applicable  
    polypeptide ENSMUSP00000091381 Ensembl | MGI Sequence Detail 1135 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      2 Sequences
    • Protein Ontology
      PR:000008250 glutamate receptor ionotropic, NMDA 3A
    • InterPro Domains
      IPR015683 Ionotropic glutamate receptor
      IPR001320 Ionotropic glutamate receptor, C-terminal
      IPR019594 Ionotropic glutamate receptor, L-glutamate and glycine-binding domain
      IPR001508 Ionotropic glutamate receptor, metazoa
      IPR028082 Periplasmic binding protein-like I
      IPR001638 Solute-binding protein family 3/N-terminal domain of MltF
    Molecular
    Reagents
    less
    • All nucleic 22
      cDNA 22

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGI:3036253
    References
    more
    • Summaries
      All 72
      Developmental Gene Expression 11
      Gene Ontology 11
      Phenotypes 31
    • Earliest
      J:6648 Billings-Gagliardi S, et al., Hypomyelinated mutant mice IV: peripheral myelin in jp msd. Brain Res. 1981 Nov 30;225(2):309-17
    • Latest
      J:335422 Spirkova A, et al., Glutamate can act as a signaling molecule in mouse preimplantation embryos. Biol Reprod. 2022 Oct 11;107(4):916-927

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    last database update
    03/12/2024
    MGI 6.23
    The Jackson Laboratory